ChemicalBook > CAS DataBase List > T-26c

T-26c

Product Name
T-26c
CAS No.
869296-13-9
Chemical Name
T-26c
Synonyms
T-26c;CPD1612;T-26c >=98% (HPLC);T-26c, 10 mM in DMSO;T26c,Inhibitor,Matrix metalloproteinases,MMP,T-26c,T 26c,inhibit;4-(((2-((3-Methoxybenzyl)carbamoyl)-4-oxo-1,4-dihydrothieno[2,3-d]pyrimidin-5-yl)methoxy)methyl)benzoic acid;Benzoic acid, 4-[[[1,4-dihydro-2-[[[(3-methoxyphenyl)methyl]amino]carbonyl]-4-oxothieno[2,3-d]pyrimidin-5-yl]methoxy]methyl]-
CBNumber
CB63381025
Molecular Formula
C24H21N3O6S
Formula Weight
479.51
MOL File
869296-13-9.mol
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T-26c Property

storage temp. 
Store at -20°C
solubility 
DMSO: 10 mg/ml
form 
A crystalline solid
color 
White to off-white
InChIKey
CDQRIIUMNLMHRH-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC=C(COCC2C3C(=O)N=C(C(NCC4=CC=CC(OC)=C4)=O)NC=3SC=2)C=C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1915
Product name
T-26c
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$109.25
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1915
Product name
T-26c
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$295
Updated
2025/07/31
Cayman Chemical
Product number
19962
Product name
T-26c
Packaging
5mg
Price
$120
Updated
2024/03/01
Cayman Chemical
Product number
19962
Product name
T-26c
Packaging
10mg
Price
$220
Updated
2024/03/01
Cayman Chemical
Product number
19962
Product name
T-26c
Packaging
1mg
Price
$38
Updated
2024/03/01
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T-26c Chemical Properties,Usage,Production

Uses

T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes[1].

Biological Activity

T-26c is a highly potent, selective and cell-permeable matrix metalloproteinases 13 (MMP-13) inhibitor. T-26c inhibits the breakdown of collagen (87.4% inhibition at 0.1 μM) in IL-1b and oncostatin M stimulated cartilage. For full characterization details, please visit the T-26c probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc

in vivo

T-26c is well absorbed in all species at the oral dose of 10–20 mg/kg. Oral administration of the disodium salt formulations of T-26c to guinea pigs results in significant increases in AUC (8357 ng h/mL) and Cmax (1445 ng/ mL) compared with those of the free acid T-26c (AUC = 6478 ng h/ mL and Cmax= 911 ng/mL)[1].

References

[1] Nara H, et al. Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1″ binding site. Bioorg Med Chem. 2014 Oct 1;22(19):5487-505. DOI:10.1016/j.bmc.2014.07.025

T-26c Preparation Products And Raw materials

Raw materials

Preparation Products

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T-26c Suppliers

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869296-13-9, T-26cRelated Search:

BAY 299 AZD-7594 4-[4-(1-methyl-1H-pyrazol-4-yl)-1-[2-(1-methyl-1H-pyrazol-4-yl)ethyl]-1H-imidazol-5-yl]-benzonitrile ABBV-744 Zofluza intermediate RGX-104 HCl Adavivint

  • CPD1612
  • T-26c
  • Benzoic acid, 4-[[[1,4-dihydro-2-[[[(3-methoxyphenyl)methyl]amino]carbonyl]-4-oxothieno[2,3-d]pyrimidin-5-yl]methoxy]methyl]-
  • T-26c >=98% (HPLC)
  • T26c,Inhibitor,Matrix metalloproteinases,MMP,T-26c,T 26c,inhibit
  • 4-(((2-((3-Methoxybenzyl)carbamoyl)-4-oxo-1,4-dihydrothieno[2,3-d]pyrimidin-5-yl)methoxy)methyl)benzoic acid
  • T-26c, 10 mM in DMSO
  • 869296-13-9