ChemicalBook > CAS DataBase List > 3,4-Dimethoxyacetophenone

3,4-Dimethoxyacetophenone

Synthesis

Product Name: 3,4-Dimethoxyacetophenone
CAS No.: 1131-62-0
Chemical Name: 3,4-Dimethoxyacetophenone
Synonyms: 1-(3,4-DIMETHOXYPHENYL)ETHAN-1-ONE;ACETOVERATRONE;3,4-Dimethoxyacetophenon;3,4-Dimethoxyacetoph;Dimethoxyacetophenone;1-(3,4-DIMETHOXYPHENYL)-ETHANONE;KML-86;KML-118;AKOS 220-35;ACETOVERATRON
CBNumber: CB6350428
Molecular Formula: C10H12O3
Formula Weight: 180.2
MOL File: 1131-62-0.mol

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3,4-Dimethoxyacetophenone Property

Melting point:: 47-54 °C(lit.)
Boiling point:: 286-288 °C(lit.)
Density: 1.1272 (rough estimate)
refractive index: 1.5224 (estimate)
Flash point:: >230 °F
storage temp.: Sealed in dry,Room Temperature
solubility: hot water: soluble
form: Crystalline Powder
color: Yellow to beige
Odor: at 10.00 % in dipropylene glycol. sweet woody floral
Odor Type: woody
Water Solubility: SOLUBLE IN HOT WATER
BRN: 781213
LogP: 1.822 (est)
CAS DataBase Reference: 1131-62-0(CAS DataBase Reference)
NIST Chemistry Reference: Ethanone, 1-(3,4-dimethoxyphenyl)-(1131-62-0)
EPA Substance Registry System: Ethanone, 1-(3,4-dimethoxyphenyl)- (1131-62-0)

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Safety

Hazard Codes: Xi
Safety Statements: 24/25
WGK Germany: 3
TSCA: Yes
HS Code: 29145000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 156639
Product name: 3′,4′-Dimethoxyacetophenone
Purity: 98%
Packaging: 25g
Price: $64.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 156639
Product name: 3′,4′-Dimethoxyacetophenone
Purity: 98%
Packaging: 100g
Price: $205
Updated: 2025/07/31

TCI Chemical

Product number: D1878
Product name: 3',4'-Dimethoxyacetophenone
Purity: >98.0%(GC)
Packaging: 25g
Price: $48
Updated: 2025/07/31

TCI Chemical

Product number: D1878
Product name: 3',4'-Dimethoxyacetophenone
Purity: >98.0%(GC)
Packaging: 100g
Price: $122
Updated: 2025/07/31

TCI Chemical

Product number: D1878
Product name: 3',4'-Dimethoxyacetophenone
Purity: >98.0%(GC)
Packaging: 500g
Price: $375
Updated: 2025/07/31

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3,4-Dimethoxyacetophenone Chemical Properties,Usage,Production

Synthesis

To a stirred mixture of 3´,4´-dihydroxyacetophenone (100 mg, 0.66 mmol) and anhydrous K2CO3 (5 g, 36 mmol) in dry acetone (10 mL) was added MeI (1 mL, 16 mmol). The mixture was heated at reflflux for 45 min, cooled to room temperature, fifiltered, and evaporated under reduced pressure. The residue was dissolved in CH2Cl2, washed with 2 portions of water, dried over anhydrous Na2SO4, and evaporated under reduced pressure. The product was purifified by flflash chromatography (silica, hexane/EtOAc 4:1, v/v). Removal of the solvent gave a 93% yield of the product, 3´,4´-dimethoxyacetophenone (110 mg, 0.61 mmol). Reference: Khatib, S.; Nerya, O.; Musa, R.; Shmuel, M.; Tamir, S.; Vaya, J. Bioorg. Med. Chem. 2005, 13, 433−441.

Chemical Properties

yellow to beige crystalline powder

Uses

3',4'-Dimethoxyacetophenone is used as Catalytic agent; Petrochemical additive. It is also used in agrochemical, pharmaceutical and dyestuff field.

Definition

ChEBI: A member of the class of acetophenones that is acetophenone substituted by methoxy groups at positions 3' and 4' respectively.

Preparation

Obtained by reaction of dimethyl sulfate with acetoguaiacone in the presence of sodium hydroxide in ethanol, first at 50°, then at reflux for 1 h (78%).

Synthesis Reference(s)

Tetrahedron Letters, 36, p. 409, 1995 DOI: 10.1016/0040-4039(94)02221-V

References

[1] G. Hawkes. “An unusual anodic methoxylation: 3,4-dimethoxyacetophenone.” Tetrahedron Letters 33 1 (1992): 8133–8136.
[2] P. Kuzmi?, M. Soucek. “Substituent effects in aromatic photochemistry. UV irradiation of 3,4-dimethoxybenzonitrile and 3,4-dimethoxyacetophenone in the presence of inorganic anions.” Collection of Czechoslovak Chemical Communications 52 1 (1987): 980–988.
[3] Virginia Vetere . “Study of the racemic and enantioselective hydrogenation of acetophenone and 3,4-dimethoxyacetophenone using platinum-based organotin catalysts.” Catalysis Today 107 (2005): Pages 266-272.

3,4-Dimethoxyacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4-Dimethoxyacetophenone Suppliers

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View Lastest Price from 3,4-Dimethoxyacetophenone manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3,4-Dimethoxyacetophenone 1131-62-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-04

Hebei Yiduo Import and Export Co., Ltd.

Product: 3,4-Dimethoxyacetophenone 1131-62-0
Price: US $100.00-80.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000000
Release date: 2025-03-12

Hebei Yanxi Chemical Co., Ltd.

Product: 3,4-Dimethoxyacetophenone 1131-62-0
Price: US $0.00-0.00/KG
Min. Order: 25KG
Purity: 99%
Supply Ability: 50MT/month
Release date: 2024-05-09

1131-62-0, 3,4-DimethoxyacetophenoneRelated Search:

PIPERACETAZINE (250 MG) 4'-Methylacetophenone Acetophenone 4-Nitroacetophenone 3-Nitroacetophenone 4'-Methoxyacetophenone 2-Bromoacetophenone 4'-Hydroxyacetophenone 3-Methoxyacetophenone 2'-Methoxyacetophenone Dimethyldimethoxysilane 2-(3,4-Dimethoxyphenyl)ethanol (3,4-Dimethoxyphenyl)acetonitrile Veratraldehyde 3,4-Dimethoxyphenylacetone 3',5'-DIMETHOXYACETOPHENONE,3,5-DIMETHOXYACETOPHENONE,3',5'-Dimethoxyacetophenone 3,5-Dimethoxyacetophenone 2',3',4'-TRIMETHOXYACETOPHENONE 6-Acetyl-1,4-benzodioxane

Dimethoxyacetophenone

3,4-Dimethoxyacetoph

3,4-DIMETHOXYACETOPHENONE FOR SYNTHESIS

3,4-Dimethoxyacetophenone≥ 99% (GC)

3,4-DIMETHOXYACETOPHENONE

3,4-dimethoxyacetophenone (acetoveratrone)

3',4'-Dimethoxyacetophenone 1-(3,4-Dimethoxyphenyl)ethan-1-one 3,4-Dimethoxyacetophenone

3,4-dimethoxyacetophene

1-(3,4-Dimethoxyphenyle)ethane-1-one

Acetyl veratrole

3' 4'-DIMETHOXYACETOPHENONE 98+%

ACETYL VERATROL

ACETOVERATRONE(RG)

1-(3,4-dimethoxyphenyl)-ethanon

LABOTEST-BB LT00000195

3,4-Dimethoxyacetophenon

3,4-Dimethoxyphenyl methyl ketone

3,4-Dimethoxyphenylmethylketone

Acetophenone, 3',4'-dimethoxy-

Acetophenone,3’,4’-dimethoxy-

Ethanone,1-(3,4-dimethoxyphenyl)-

Methyl3,4-dimethoxyphenylketone

1-(3,4-DIMETHOXYPHENYL)-ETHANONE

1-(3,4-DIMETHOXYPHENYL)-ETHANO

1-(3,4-DIMETHOXYPHENYL)ETHAN-1-ONE

ACETOVERATRON

ACETOVERATRONE

AKOS 220-35

AKOS BBS-00003221

4-ACETYLPYROCATECHOL DIMETHYL ETHER

4-ACETYLVERATROLE

3',4'-Dimethoxyacetophenone&gt

KML-86

3',4'-Dimethoxyacetophenone1131-62-0

KML-118

Compound PDK0029

3,4-DChemicalbookIMETHOXYACETOPHENONE

3',4'-Dimethoxyacetophenone

3',4'-Dimethoxyacetophenone, 97%

1131-62-0

1131-62-7

1132-62-0

KETONE

Ketones

Organic Building Blocks

Building Blocks

C10

Carbonyl Compounds

Alphabetical Listings

C-D

Flavors and Fragrances

C10

Carbonyl Compounds

Ketones

Benzene derivatives

Aromatic Acetophenones & Derivatives (substituted)

1131-62-0