Imazameth

Product Name: Imazameth
CAS No.: 104098-48-8
Chemical Name: Imazameth
Synonyms: CADRE;IMAZAPI;IMAZAPIC;IMAZAMETH;Imazapic 70%WG;AC 263, 222(TM);imazapic(bsi,iso);Imazapic, Pestanal;C14282500 Imazapic;Pirarubicine Impurity 9
CBNumber: CB6354097
Molecular Formula: C14H17N3O3
Formula Weight: 275.3
MOL File: 104098-48-8.mol

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Imazameth Property

Melting point:: 205-207°C
Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: 0-6°C
solubility: DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly, Sonicated)
pka: 10.72±0.40(Predicted)
form: Solid
color: White to Off-White
LogP: 2.470
CAS DataBase Reference: 104098-48-8(CAS DataBase Reference)
EPA Substance Registry System: Imazapic (104098-48-8)

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Safety

WGK Germany: 3
RTECS: US7079100
HS Code: 29333990
Hazardous Substances Data: 104098-48-8(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 34179
Product name: Imazapic
Purity: PESTANAL
Packaging: 100mg
Price: $108
Updated: 2024/03/01

TRC

Product number: I268635
Product name: Imazapic
Packaging: 500mg
Price: $85
Updated: 2021/12/16

AK Scientific

Product number: J51132
Product name: Imazapic
Packaging: 5g
Price: $298
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0077251
Product name: IMAZAPIC
Purity: 95.00%
Packaging: 5G
Price: $909.56
Updated: 2021/12/16

DC Chemicals

Product number: DC8678
Product name: Imazapic
Purity: >98%
Packaging: 1g
Price: $300
Updated: 2021/12/16

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Imazameth Chemical Properties,Usage,Production

Uses

Imazapic is registered throughout the world for use in peanuts, rangeland, sugarcane, and imidazolinoneresistant canola (12). A nonionic surfactant or oil adjuvant is required for maximum activity.

Uses

Imazapic can be used in analytical and biological studies of residue analysis and determination of imidazolinone herbicides in sunflower and soil by GC-MS.

Definition

ChEBI: 5-methyl-2-[4-methyl-5-oxo-4-(propan-2-yl)-4,5-dihydro-1H-imidazol-2-yl]pyridine-3-carboxylic acid is a pyridinemonocarboxylic acid that is 5-methylpyridine-3-carboxylic acid which is substituted at position 2 by a 4,5-dihydro-imidazol-2-yl group, which in turn is substituted at positions 4, 4, and 5 by isopropyl, methyl, and oxo groups, respectively. It is a pyridinemonocarboxylic acid, an imidazolone, a member of imidazolines and a member of methylpyridines.

Pharmacology

Imazapic kills plants by inhibiting acetolactate synthase (ALS) (I50 = 1 μM), which is the first common enzyme in the biosynthesis of the branched chain amino acids, valine, leucine, and isoleucine. Imazapic is rapidly absorbed through the leaves of plants. Once it enters the plant, imazapic translocates to the growing points and growth ceases within 1 day after herbicide application followed by chlorosis and then necrosis of the growing points. Total plant death will occur within 2 to 3 weeks after treatment.

Environmental Fate

Imazapic is weakly to moderately adsorbed on sandy loam and silt loam soils. The Freundlich adsorption coefficient ranges from 0.17 to 2.99, (12). Because imazapic is a weak acid and exists in different ionic states, soil pH has an effect on soil binding properties. The anionic form predominates at soil pH as low as 5.5, and this form binds weakly to soil. The neutral or molecular form is important at soil pH from 4 to 6.5. This form binds to soil organic matter and clay. The cationic form is important at pH less than 4. Because the soil is a heterogeneous mixture of acid and base chemical groups, there may be sites within a particular soil that are 2 to 3 pH units higher or lower than the average pH. The cationic form will bind tightly to the lower pH components. Because of these interactions, small decreases in pH below 6 will result in large increases in binding. The half-life of imazapic in the soil is 106 d. Imazapic remains in the top 30 cm of the soil with low leaching potential. The degradation route of imazapic in the soil has not been determined.

Metabolism

Plant Metabolism. The selectivity of imazapic is due to differential rates and routes of metabolism in tolerant crops versus susceptible weeds(10). Imazapic has excellent selectivity in peanuts, but is not selective in soybeans. The difference in the tolerance of these two legumes is due to the different routes of metabolism of imazapic in the two crops. The primary metabolite in soybeans is an imidazopyrrolo-pyridine derivative, whereas in peanuts, the primary metabolite is the glucose conjugate of hydroxy-imazapic. Although the imidazopyrrolo-pyridine derivative formed in soybean is immobile and is not an inhibitor of acetolactate synthase, the rate of degradation of imazapic in soybeans is not rapid enough for selectivity (10). In imidazolinone-resistant crops, the primary mechanism of selectivity is due to an altered acetolactate synthase that is not inhibited by the imazapic (11).
Animal Metabolism (12). Metabolism studies in the rat showed that imazapic is rapidly excreted in the urine. There was no accumulation of imazapic or any of its derivatives in the liver, kidney, muscle, fat, or blood.

Toxicity evaluation

Imazapic has shown no mutagenic or genotoxic activity in the Ames assay, mammalian cell gene mutation assay, in vitro chromosome aberration assay, in vitro unscheduled DNA synthesis (URS) assay, or the in vivo dominant lethal assay inmale rats. The acute toxicity and effects on wildlife and soil microflora of imazapic are shown in Table 6. This herbicide also has a low potential for bioaccumulation in fish.

Imazameth Preparation Products And Raw materials

Raw materials

Preparation Products

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Imazameth Suppliers

China 112 Germany 2 India 1 Japan 2 Switzerland 1 United Kingdom 2 United States 16 Global 136

MedChemexpress LLC

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View Lastest Price from Imazameth manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: Imazameth 104098-48-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-04

Hebei Mojin Biotechnology Co.,Ltd

Product: Imazameth 104098-48-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2024-08-01

Hebei Kangcang new material Technology Co., LTD

Product: Imazapic 104098-48-8
Price: US $20.00-10.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 20
Release date: 2024-04-25

104098-48-8, ImazamethRelated Search:

Methyl acetate Methimazole Sodium carboxymethyl cellulose METSULFURON METHYL Imidazole Dimethyl sulfoxide Clotrimazole Methyl cellulose POLYDIMETHYLSILOXANE Thiophanate-methyl Imazapyr acid Tribenuron methyl Fluroxypyr Methyl salicylate Methyl methacrylate 5-Ethyl-2-(4-isopropyl-4-methyl-5-oxo-1H-imidazolin-2-yl)nicotinic acid N,N-Dimethylformamide Imazapic-ammonium

2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-5-methylnicotinic acid

imazapic(bsi,iso)

CADRE

Imazapic, Pestanal

IMAZAPIC

IMAZAMETH

(+/-)-2-(4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1h-imidazol-2-yl)-5-methyl-3-pyridinecarboxylic acid

AC 263, 222(TM)

(+/-)-2-(4,5-Dihydro-4-Methyl-4-(1-Methylethyl)-5-oxo-1H-iMidazol-2-yl)-5-Methyl-3-pyridin

IMAZAPI

2-(4-Isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-5-methylnicotinic acid, 2-[4,5-Dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl]-5-methyl-3-pyridinecarboxylic acid

2-(5-Isopropyl-5-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)-5-methylnicotinic acid

Imazapic,2-(4-Isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-5-methylnicotinic acid, 2-[4,5-Dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl]-5-methyl-3-pyridinecarboxylic acid

5-methyl-2-(4-methyl-5-oxo-4-propan-2-yl-1H-imidazol-2-yl)-3-pyridinecarboxylic acid

Imazapic@1000 μg/mL in Acetonitrile

Imazapic@100 μg/mL in Acetonitrile

Imazapic 70%WG

Pirarubicine Impurity 9

C14282500 Imazapic

Imazapic 10 μg/ml Acetonitrile

Imazapic in Acetonitrile

104098-48-8

C14H17N3O3