1-Bromo-3,4,5-trimethoxybenzene
- Product Name
- 1-Bromo-3,4,5-trimethoxybenzene
- CAS No.
- 2675-79-8
- Chemical Name
- 1-Bromo-3,4,5-trimethoxybenzene
- Synonyms
- 5-BROMO-1,2,3-TRIMETHOXYBENZENE;3,4,5-Trimethoxybrombenzene;BROMOTRIMETHOXYBENZENE;3,4,5-Trimethoxybromoben;3,4,5-TRIMETHOXYBROMOBENZENE;3,4,5-rimethoxyboromobenzene;3,4,5-Trimethoxyphenyl bromide;3,4,5-triemethoxyphenylbromide;1-BROMO-3,4,5-TRIMETHOXYBENZENE;5-Bromopyrogallol trimethyl ether
- CBNumber
- CB6354163
- Molecular Formula
- C9H11BrO3
- Formula Weight
- 247.09
- MOL File
- 2675-79-8.mol
1-Bromo-3,4,5-trimethoxybenzene Property
- Melting point:
- 78-82 °C(lit.)
- Boiling point:
- 273°C/747mmHg(lit.)
- Density
- 1.5463 (rough estimate)
- refractive index
- 1.4730 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- color
- White to Light yellow to Light orange
- Water Solubility
- Insoluble in water.
- InChI
- InChI=1S/C9H11BrO3/c1-11-7-4-6(10)5-8(12-2)9(7)13-3/h4-5H,1-3H3
- InChIKey
- XAOOZMATJDXDQJ-UHFFFAOYSA-N
- SMILES
- C1(OC)=CC(Br)=CC(OC)=C1OC
- CAS DataBase Reference
- 2675-79-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 634530
- Product name
- 5-Bromo-1,2,3-trimethoxybenzene
- Purity
- 97%
- Packaging
- 10g
- Price
- $144.4
- Updated
- 2025/07/31
- Product number
- 634530
- Product name
- 5-Bromo-1,2,3-trimethoxybenzene
- Purity
- 97%
- Packaging
- 100g
- Price
- $256.2
- Updated
- 2025/07/31
- Product number
- B4739
- Product name
- 5-Bromo-1,2,3-trimethoxybenzene
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $38
- Updated
- 2025/07/31
- Product number
- B4739
- Product name
- 5-Bromo-1,2,3-trimethoxybenzene
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $149
- Updated
- 2025/07/31
- Product number
- B688703
- Product name
- 1-Bromo-3,4,5-trimethoxybenzene
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
1-Bromo-3,4,5-trimethoxybenzene Chemical Properties,Usage,Production
Uses
5-Bromo-1,2,3-trimethoxybenzene is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.
Synthesis
619-42-1
213596-33-9
2675-79-8
The general procedure for the synthesis of 1-bromo-3,4,5-trimethoxybenzene from methyl p-bromobenzoate and 2-(4-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborole cyclohexane is as follows: aryl halide (0.67 mmol, 1.0 eq.), aryl boronate (0.81 mmol, 1.2 eq.) were added to a Schlenk tube in the following order, potassium phosphate or CsF (3.0 eq.), Pd catalyst (0.1 eq.) and 2-(dicyclohexylphosphino)biphenyl (0.2 eq.). When using Pd(OAc)2 as the catalyst, CsF is required as the base (see Table 8, entries 13-15). Subsequently, a PTFE-coated stirrer was added to the reaction system and the reaction was carried out at room temperature. The reaction mixture was degassed under high vacuum three times for 10 min each and backfilled with nitrogen. Anhydrous dioxane was added through the T-neck and the reaction mixture was heated to 110°C and kept for 18 hours. Upon completion of the reaction, the mixture was cooled to room temperature and diluted with dichloromethane (10 mL). The reaction solution was filtered and the filtrate was washed with dichloromethane (100 mL). Finally, the filtrate was concentrated and purified by silica gel column chromatography.
References
[1] Patent: WO2009/137322, 2009, A2. Location in patent: Page/Page column 21; 22; 29; 30; 31
1-Bromo-3,4,5-trimethoxybenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Bromo-3,4,5-trimethoxybenzene manufacturers
- Product
- 1-Bromo-3,4,5-trimethoxybenzene 2675-79-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-25
- Product
- 1-Bromo-3,4,5-trimethoxybenzene 2675-79-8
- Price
- US $80.00-45.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-09-27
- Product
- 3.4.5-Trimethoxyphenylbromide 2675-79-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10