1-AMINO-3,3-DIETHOXYPROPANE

1-AMINO-3,3-DIETHOXYPROPANE Property

Boiling point:

72 °C (12.0016 mmHg)

Density 

0.91 g/mL at 25 °C(lit.)

refractive index 

1.4233-1.4253

Flash point:

78 °C

storage temp. 

room temp

solubility 

Soluble in water, alcohol, and petroleum ether.

pka

8.92±0.13(Predicted)

form 

liquid

color 

Clear colorless to yellow

biological source

synthetic (organic)

Water Solubility 

water: miscible

Sensitive 

Air Sensitive

InChI

InChI=1S/C7H17NO2/c1-3-9-7(5-6-8)10-4-2/h7H,3-6,8H2,1-2H3

InChIKey

PXXMSHBZYAOHBD-UHFFFAOYSA-N

SMILES

C(N)CC(OCC)OCC

CAS DataBase Reference

41365-75-7(CAS DataBase Reference)

Safety

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-27-36/37/39-45

RIDADR 

UN 3267 8/PG 2

WGK Germany 

3

HazardClass 

8

PackingGroup 

I

HS Code 

29221985

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

1-AMINO-3,3-DIETHOXYPROPANE Chemical Properties,Usage,Production

Chemical Properties

CLEAR COLOURLESS TO YELLOW LIQUID

Uses

1-Amino-3,3-diethoxypropane has been used:

• with alginate in the preparation of hydrogel
• in the generation of polyethylene glycol (PEG) polyethylenimine (PEI) polyplexes conjugate for transfection studies in hepatocellular carcinoma cell cultures
• as a component of pH-sensitive PEG derivative for lipopolyplexes formation

General Description

1-Amino-3,3-diethoxypropane is an effective modulator of alginate and chitosan based hydrogels and effectively used for the delivery of bone marrow stromal cells (BMSCs) for regeneration of cartilage.

Synthesis

The general procedure for the synthesis of 1-amino-3,3-diethoxypropane from the compound (CAS:107833-73-8) was as follows: 10% Pd/C catalyst (15 mg) was added to a solution of compound 5 (17.7 g, 0.1 mol) in methanol (20 mL), and the reaction was stirred for 12 hr at room temperature and 10 atmospheres of hydrogen atmosphere. After completion of the reaction, the filtrate was filtered through diatomaceous earth and concentrated under reduced pressure to afford compound 6 (14.4 g, 98% yield) as a colorless oil. The product was characterized by 1H NMR (400 MHz, CDCl3): δ = 1.14 (t, 6H, J = 6.8 Hz), 1.29 (br s, 2H), 1.71 (q, 2H, J = 6.4 Hz), 2.73 (t, 2H, J = 6.4 Hz), 3.45 (q, 2H, J = 7.2 Hz), 3.60 (q, 2H, J = 7.2 Hz), 4.53 (t, 1H, J=5.2 Hz). IR (pure sample): 3385,2953,2831,1621,1389 cm-1; mass spectrum (EI): m/z: 147 [M+].

References

[1] Tetrahedron Asymmetry, 2013, vol. 24, # 4, p. 207 - 211