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NADP sodium salt

Product Name
NADP sodium salt
CAS No.
1184-16-3
Chemical Name
NADP sodium salt
Synonyms
TPN;NADP SODIUM SALT;β-Nicotinamide Adenine Dinuclotide Phosphate;NADP Sodium;NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE SODIUM SALT;beta-Nicotinamide adenine dinucleotide phosphate hydrate;β-Nicotinamide Adenine Dinucleotide Phosphate Sodium Salt Hydrate;β-NicotinaMide Adenine Dinucleotide Phosphate SodiuM Salt Hydrate (~90%);beta-NicotinaMide Adenine Dinucleotide Phosphate SodiuM Salt Hydrate, oxidized forM [for BiocheMical Research];TPN-NA
CBNumber
CB6355458
Molecular Formula
C21H29N7NaO17P3
Formula Weight
767.41
MOL File
1184-16-3.mol
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NADP sodium salt Property

Melting point:
175-178 °C (dec.)(lit.)
storage temp. 
-20°C
solubility 
H2O: 50 mg/mL
form 
powder
color 
off-white to yellow
PH
2.0-4.0
Water Solubility 
Soluble in water.
Merck 
14,6344
BRN 
4779954
InChI
InChI=1/C21H28N7O17P3.Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32;/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39);/q;+1/p-1/t10-,11-,13-,14-,15-,16-,20-,21-;/s3
InChIKey
JNUMDLCHLVUHFS-QYZPTAICSA-M
SMILES
[C@H]1(O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@@H]2[C@@H](O)[C@@H](O)[C@H]([N+]3C=CC=C(C(=O)N)C=3)O2)[C@@H](O)[C@H]1OP(=O)(O)O)N1C=NC2C(N)=NC=NC1=2.[Na+] |&1:0,2,14,15,17,19,30,32,r|
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
36-36/37/38
Safety Statements 
22-24/25-37/39-36-26
WGK Germany 
3
RTECS 
UU3440000
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
481971-M
Product name
NADP, Monosodium Salt - CAS 1184-16-3 - Calbiochem
Purity
A coenzyme that is widely distributed in living matter. Participates in oxidation-reduction reactions. Spectra (pH 7.0): 250 nm/260 nm: 0.78-0.88; 280 nm/260 nm: 0.16-0.26.
Packaging
481971-100MG
Price
$97.6
Updated
2024/03/01
Sigma-Aldrich
Product number
481971-M
Product name
NADP, Monosodium Salt - CAS 1184-16-3 - Calbiochem
Purity
A coenzyme that is widely distributed in living matter. Participates in oxidation-reduction reactions. Spectra (pH 7.0): 250 nm/260 nm: 0.78-0.88; 280 nm/260 nm: 0.16-0.26.
Packaging
481971-500MG
Price
$288
Updated
2024/03/01
Sigma-Aldrich
Product number
N8160
Product name
β-Nicotinamide adenine dinucleotide phosphate sodium salt
Purity
pkgof10?mg(pervial)
Packaging
15vials
Price
$379
Updated
2024/03/01
Sigma-Aldrich
Product number
481971-M
Product name
NADP, Monosodium Salt - CAS 1184-16-3 - Calbiochem
Purity
A coenzyme that is widely distributed in living matter. Participates in oxidation-reduction reactions. Spectra (pH 7.0): 250 nm/260 nm: 0.78-0.88; 280 nm/260 nm: 0.16-0.26.
Packaging
481971-1GM
Price
$434
Updated
2024/03/01
Sigma-Aldrich
Product number
N8035
Product name
β-Nicotinamide adenine dinucleotide phosphate sodium salt
Purity
pkgof5?mg(pervial)
Packaging
15vials
Price
$263
Updated
2024/03/01
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NADP sodium salt Chemical Properties,Usage,Production

Description

The nicotinamide adenine dinucleotide phosphate oxidase（NADP）is a multicomponent system that transfers an electron to molecular oxygen by way of FAD and heme to form superoxide (O2?) .Cytochrome b558 is a membrane-bound heterodimer lodged in the wall of the secondary granules; the large glycosylated β subunit is gp91phox and the small nonglycosylated α subunit is p22phox.The cytoplasmic tail of gp91phox binds FAD, heme, and NADPH, which are required for electron transfer to oxygen (O2).Neutrophil stimulation leads to aggregation and phosphorylation of p47phox, p67phox, p40phox, and the small guanosine triphosphate (GTP)–binding proteins RAC1/RAC2, which dock with the cytochrome at the membrane through binding of p47phox and p22phox.

Description

Nicotinamide adenine dinucleotide phosphate, abbreviated NADP+ or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NADPH as a reducing agent ('hydrogen source').It is used by all forms of cellular life.

Chemical Properties

White to slightly yellowish powder

Uses

β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions.
β-Nicotinamide Adenine Dinucleotide Phosphate Sodium Salt Hydrate is a substrate NADP which plays a role in a variety of metabolic processes.

Uses

β-Nicotinamide adenine dinucleotide phosphate monosodium salt acts as an electron acceptor used by cells. It is also useful in vitro to study NADP. Furthermore, it is used in a wide range of enzyme catalyzed oxidation reduction reactions. The combination of NADP+/NADPH is employed in a variety of antioxidation mechanisms, which protect against reactive oxidation species accumulation.

Biosynthesis

In general, NADP+ is synthesized before NADPH is. Such a reaction usually starts with NAD+ from either the de-novo or the salvage pathway, with NAD+ kinase adding the extra phosphate group. ADP-ribosyl cyclase allows for synthesis from nicotinamide in the salvage pathway, and NADP+ phosphatase can convert NADPH back to NADH to maintain a balance.Some forms of the NAD+ kinase, notably the one in mitochondria, can also accept NADH to turn it directly into NADPH.[3][4] The prokaryotic pathway is less well understood, but with all the similar proteins the process should work in a similar way.

Biochem/physiol Actions

Electron acceptor

Mechanism of action

NADP sodium salt exerts its effect by competitively inhibiting nucleotide metabolism through the suppression of enzymes like nucleoside diphosphate kinase (NDPK) and adenosine kinase (ADK). Additionally, it serves as a substrate for enzymes like DNA polymerases and RNA polymerases, enabling the integration of NADP monosodium salt into nucleic acids during replication and transcription.

NADP sodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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NADP sodium salt Suppliers

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View Lastest Price from NADP sodium salt manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.
Product
beta-Nicotinamide adenine dinucleotide phosphate sodium salt,Beta-NADP-Na 1184-16-3
Price
US $0.00-0.00/g
Min. Order
10g
Purity
99% HPLC
Supply Ability
10000
Release date
2024-09-20
Wuhan Fortuna Chemical Co.,Ltd
Product
NADP sodium salt 1184-16-3
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99%
Supply Ability
1000g
Release date
2024-08-26
Hebei Kingfiner Technology Development Co.Ltd
Product
BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE SODIUM SALT 1184-16-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000kg
Release date
2023-10-24

1184-16-3, NADP sodium salt Related Search:

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