3'-Deoxycytidine Property

Melting point:

230-232 °C

Boiling point:

497.6±55.0 °C(Predicted)

Density 

1.73±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

pka

14.01±0.60(Predicted)

form 

Solid

color 

White to light yellow

InChI

InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-6(14)3-5(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1

InChIKey

ZHHOTKZTEUZTHX-SHYZEUOFSA-N

SMILES

OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](O)C1

Safety

RTECS 

HA3830000

HS Code 

29389090

Hazard and Precautionary Statements (GHS)

3'-Deoxycytidine Chemical Properties,Usage,Production

Uses

3'-Deoxycytidine is an inhibitor of nucleolar RNA synthesis but does not affect the appearance of mRNA. Displayed inhibitory properties against the replication of hepatitis C virus-like RNA template.

Biological Activity

3'-Deoxycytidine is a pyrimidine analog of cordycepin. The structures of cordycepin and 3'-deoxycytidine resemble adenosine and cytidine except for the altered 3' position in the ribose moiety, where hydrogen is substituted for the hydroxyl group. 3'-deoxycytidine affects similar to that of cordycepin on nucleolar RNA formation and has approximately the same level of activity as the adenosine analog. 3'-deoxycytidine, like cordycepin, enters cells and is phosphorylated by the appropriate enzymes. 3'-Deoxycytidine shares with cordycepin the ability to inhibit nucleolar RNA synthesis, but it does not affect the appearance of mRNA. Neither compound affects heterogeneous nuclear RNA (HnRNA)[1].

References

[1] Herbert T. Abelson, Sheldon Penman. “Messenger RNA formation: Resistance to inhibition by 3′-deoxycytidine.” Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis 277 1 (1972): Pages 129-133.