1H-INDAZOL-7-AMINE
- Product Name
- 1H-INDAZOL-7-AMINE
- CAS No.
- 21443-96-9
- Chemical Name
- 1H-INDAZOL-7-AMINE
- Synonyms
- 1H-Indazol-5-ylamine;7-AMinoindazole;1H-INDAZOL-7-AMINE;7-AMINO (1H)INDAZOLE;1H-Indazol-7-ylaMine;7-Amino-1H-indazole 97%;1H-Indazol-7-amine ,97%;7-Amino-1H-indazole ,97%;7-AMino-1H-indazole;1H-Indazol-7-amine (9CI, ACI)
- CBNumber
- CB6379225
- Molecular Formula
- C7H7N3
- Formula Weight
- 133.15
- MOL File
- 21443-96-9.mol
1H-INDAZOL-7-AMINE Property
- Melting point:
- 157-163 °C
- Boiling point:
- 376.6±15.0 °C(Predicted)
- Density
- 1.367±0.06 g/cm3(Predicted)
- RTECS
- NK7713000
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- Crystalline Solid
- pka
- 14.89±0.40(Predicted)
- color
- Tan
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 34-36/37/38-22
- Safety Statements
- 26-36/37/39
- RIDADR
- 3259
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 717096
- Product name
- 7-Amino-1H-indazole
- Purity
- 97%
- Packaging
- 1g
- Price
- $33.2
- Updated
- 2023/06/20
- Product number
- A3355
- Product name
- 1H-Indazol-7-amine
- Packaging
- 1G
- Price
- $34
- Updated
- 2025/07/31
- Product number
- A3355
- Product name
- 1H-Indazol-7-amine
- Packaging
- 5G
- Price
- $102
- Updated
- 2025/07/31
- Product number
- I509008
- Product name
- 1H-Indazol-7-amine
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- Y5344
- Product name
- 1H-Indazol-7-amine
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
1H-INDAZOL-7-AMINE Chemical Properties,Usage,Production
Chemical Properties
Light yellow solid
Uses
1H-Indazol-7-amine is a substituted-indazole, an inhibitor of nitric oxide synthases.
Synthesis
2942-42-9
21443-96-9
General procedure for the synthesis of 7-aminoindazole from 7-nitroindazole: 7-nitroindazole (100 mg, 0.67 mmol) was dissolved in methanol (6 mL) and Pd/C (10 wt%) was added to the reaction vessel. The reaction mixture was stirred in H2 atmosphere for 12 h at room temperature. After completion of the reaction, the mixture was filtered through a diatomaceous earth pad, the filtrates were combined and concentrated, and finally the product was purified by column chromatography. The yield was 95% (85 mg); 1H-NMR (DMSO-d6, 300 MHz) δ 12.58 (1H, br, NH), 7.91 (1H, s, Ar-H), 6.93 (1H, d, J = 9.0 Hz, Ar-H), 6.83 (1H, t, J = 9.0 Hz, Ar-H), 6.46 (1H, d, J = 6.0 Hz, Ar-H), 5.30 (2H, br, NH2).
References
[1] Journal of Medicinal Chemistry, 2002, vol. 45, # 3, p. 740 - 743
[2] Archives of Pharmacal Research, 2018, vol. 41, # 1, p. 46 - 56
[3] Patent: US2006/270686, 2006, A1. Location in patent: Page/Page column 25
[4] Patent: US2008/280891, 2008, A1. Location in patent: Page/Page column 26
[5] Patent: WO2008/8059, 2008, A1. Location in patent: Page/Page column 65
1H-INDAZOL-7-AMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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