1H-INDAZOL-4-AMINE
- Product Name
- 1H-INDAZOL-4-AMINE
- CAS No.
- 41748-71-4
- Chemical Name
- 1H-INDAZOL-4-AMINE
- Synonyms
- 4-Aminoindazole;1H-INDAZOL-4-AMINE;4-AMINO (1H)INDAZOLE;1H-indazol-4-ylamine;1H-Indazol-4-amine ,97%;4-Amine-1H-Indazole, 97%;1H-Indazol-4-amine (9CI, ACI);1H-indazol-4-amine(SALTDATA: FREE)
- CBNumber
- CB2448361
- Molecular Formula
- C7H7N3
- Formula Weight
- 133.15
- MOL File
- 41748-71-4.mol
1H-INDAZOL-4-AMINE Property
- Melting point:
- 148-150°C
- Boiling point:
- 376.6±15.0 °C(Predicted)
- Density
- 1.367±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 15.61±0.40(Predicted)
- Appearance
- Light yellow to brown Solid
- InChI
- InChI=1S/C7H7N3/c8-6-2-1-3-7-5(6)4-9-10-7/h1-4H,8H2,(H,9,10)
- InChIKey
- MDELYEBAXHZXLZ-UHFFFAOYSA-N
- SMILES
- N1C2=C(C(N)=CC=C2)C=N1
Safety
- Hazard Codes
- Xn
- Risk Statements
- 34-22-36/37/38
- Safety Statements
- 26-36/37/39-22
- RIDADR
- 3259
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I509005
- Product name
- 1H-Indazol-4-amine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 044540
- Product name
- 1H-Indazol-4-amine
- Purity
- >95%
- Packaging
- 5g
- Price
- $96
- Updated
- 2021/12/16
- Product number
- 044540
- Product name
- 1H-Indazol-4-amine
- Purity
- >95%
- Packaging
- 1g
- Price
- $27
- Updated
- 2021/12/16
- Product number
- OR16942
- Product name
- 4-Amino-1H-indazole
- Packaging
- 1g
- Price
- $43
- Updated
- 2021/12/16
- Product number
- 3H30-1-C9
- Product name
- 4-Amino-1H-indazole
- Packaging
- 1g
- Price
- $47
- Updated
- 2021/12/16
1H-INDAZOL-4-AMINE Chemical Properties,Usage,Production
Chemical Properties
Grey solid
Synthesis
2942-40-7
41748-71-4
The general procedure for the synthesis of 4-aminoindazole from 4-nitroindazole is as follows: 1. 2-Methyl-3-nitroaniline (2.27 g, 14.91 mmol) was dissolved in acetic acid (60 mL) and an aqueous solution of sodium nitrite (1.13 g, 1.1 eq.) was added (5 mL). After 2 hours of reaction, the dark red solution was poured into ice/water and the precipitate was collected by filtration to give 4-nitro-1H-indazole (1.98 g, 81% yield). 2. 4-Nitro-1H-indazole (760 mg, 4.68 mmol), charcoal-loaded palladium (10%, catalyst), and ethanol (30 mL) were stirred under a hydrogen balloon for 4 hours. Upon completion of the reaction, the solvent was removed in vacuum by filtration through diatomaceous earth to afford 1H-indazol-4-ylamine (631 mg, 100% yield). 3. A suspension of 1H-indazol-4-ylamine (63 mg, 4.74 mmol) in 6 M hydrochloric acid (7.2 mL) was added dropwise to an aqueous solution (2 mL) of sodium nitrite (337 mg, 4.89 mmol) at below 0 °C. After stirring for 30 min, sodium tetrafluoroborate (724 mg) was added. The reaction mixture formed a viscous solution, which was filtered and washed briefly with water to give 1H-indazole-4-diazotetrafluoroborate (218 mg, 20% yield) as a dark red solid. 4. Dry methanol (4 mL) was purged with argon for 5 min and 1H-indazole-4-diazotetrafluoroborate (218 mg, 0.94 mmol), bis(pinacolato)diboron (239 mg, 1.0 eq.), and [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) chloride (20 mg) were added. The reaction mixture was stirred for 5 hours and then filtered through diatomaceous earth. The residue was purified by fast chromatography to afford the target product 4-aminoindazole (117 mg).
References
[1] Patent: WO2006/46031, 2006, A1. Location in patent: Page/Page column 31-33
[2] Patent: WO2007/42806, 2007, A1. Location in patent: Page/Page column 32-33
[3] Patent: US2008/76768, 2008, A1. Location in patent: Page/Page column 9
[4] Patent: US2008/76758, 2008, A1. Location in patent: Page/Page column 74
[5] Patent: WO2012/82997, 2012, A1. Location in patent: Page/Page column 78
1H-INDAZOL-4-AMINE Preparation Products And Raw materials
Raw materials
Preparation Products
1H-INDAZOL-4-AMINE Suppliers
- Tel
- 18994340517
- 709951195@qq.com
- Country
- China
- ProdList
- 53
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9883
- Advantage
- 59
- Tel
- 10-61256048 13810278579
- Fax
- +86 10 61256049
- sales@zeroschem.com
- Country
- China
- ProdList
- 1370
- Advantage
- 59
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 15883
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 86-0571-85151182
- Fax
- 86-0571-85151182
- Country
- China
- ProdList
- 5691
- Advantage
- 66
- Tel
- +86-25-68710855, +86-25-68710897
- Fax
- 025-68710856
- sales@springpharma.net
- Country
- China
- ProdList
- 1261
- Advantage
- 62
View Lastest Price from 1H-INDAZOL-4-AMINE manufacturers
- Product
- 1H-INDAZOL-4-AMINE 41748-71-4
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-24