ChemicalBook > CAS DataBase List > 1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROETHENE

1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROETHENE

Product Name: 1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROETHENE
CAS No.: 6178-42-3
Chemical Name: 1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROETHENE
Synonyms: 2-METHOXY-4-(2-NITROVINYL)PHENOL;AURORA 3504;vanillalnitromethane;4-HYDROXY-3-METHOXYNITROSTYRENE;2-Methoxy-4-(2-nitroethenyl)phenol;β-Nitro-3-methoxy-4-hydroxystyrene;4-Hydroxy-3-methoxy-β-nitrostyrene;(E)-2-methoxy-4-(2-nitrovinyl)phenol;4-Hydroxy-3-methoxy-beta-nitrostyrene;3-METHOXY-4-HYDROXY-BETA-NITROSTYRENE
CBNumber: CB6386535
Molecular Formula: C9H9NO4
Formula Weight: 195.17
MOL File: 6178-42-3.mol

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1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROETHENE Property

Melting point:: 168-170 °C (lit.)
Boiling point:: 347.0±27.0 °C(Predicted)
Density: 1.308±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Dichloromethane, Ethyl Acetate, Methanol
form: Solid
pka: 8.09±0.18(Predicted)
color: Brown
CAS DataBase Reference: 6178-42-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Irritant
HS Code: 2904200090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S594636
Product name: 4-HYDROXY-3-METHOXY-BETA-NITROSTYRENE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $30.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: S594636
Product name: 4-HYDROXY-3-METHOXY-BETA-NITROSTYRENE
Purity: AldrichCPR
Packaging: 50mg
Price: $29.8
Updated: 2024/03/01

TRC

Product number: H946230
Product name: 4-Hydroxy-3-methoxy-β-nitrostyrene
Packaging: 2.5g
Price: $185
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 58849
Product name: 4-Hydroxy-3-methoxy-β-nitrostyrene
Packaging: 2.5g
Price: $675
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0032462
Product name: 1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROETHENE
Purity: 95.00%
Packaging: 25G
Price: $1261.26
Updated: 2021/12/16

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1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROETHENE Chemical Properties,Usage,Production

Chemical Properties

Brown Solid

Uses

β-Nitrostyrene derivative, with inhibitory activity of Src and/or Syk kinase and antibacterial activity.

Uses

trans-4-Hydroxy-3-methoxy-β-nitrostyrene may be used in the synthesis of cytotoxic β-nitrostyrene derivatives, 4-O-benzoyl-3-methoxy-β-nitrostyrene (BMNS) derivatives.

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 2781, 1950 DOI: 10.1021/ja01162a521

General Description

trans-4-Hydroxy-3-methoxy-β-nitrostyrene is a phenolic β-nitrostyrene. Synthesis of 4-hydroxy-3-methoxy-β-nitrostyrene is reported.

1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROETHENE Preparation Products And Raw materials

Raw materials

Nitromethane Ethanol solution Methylamine hydrochloride Vanillin ACETALDEHYDE AMMONIA

Preparation Products

3-O-Methyldopamine hydrochloride

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1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROETHENE Suppliers

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6178-42-3, 1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROETHENERelated Search:

3,4-Methylenedioxy-beta-nitrostyrene 1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROETHENE 3,4-DIMETHOXY-B-NITROSTYRENE 4-Hydroxystyrene Nitroethylene MNP-GLC 5-(2-NITROPROP-1-ENYL)-1,3-BENZODIOXOLE 3,4-DIMETHOXY-BETA-METHYL-BETA-NITROSTYRENE MNP-GAL TRANS-3-BENZYLOXY-4-METHOXY-BETA-NITROSTYRENE 4-BENZYLOXY-3-METHOXY-OMEGA-NITROSTYRENE 1-(3,4,5-TRIMETHOXYPHENYL)-2-NITROETHENE 1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROPROPENE 1-(5-BROMO-2-HYDROXY-3-METHOXYPHENYL)-2-NITROETHENE 1-(3-HYDROXY-4-METHOXYPHENYL)-2-NITROETHENE 1-(4-ETHOXY-3-METHOXYPHENYL)-2-NITROPROPENE 1-(3,4-(METHYLENEDIOXY)-6-NITROPHENYL)-2-NITROETHENE 4-BENZYLOXY-3-METHOXY-6-B-DINITROSTYRENE

4-Hydroxy-3-methoxy-beta-nitrostyrene

AURORA 3504

1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROETHENE

2-METHOXY-4-((E)-2-NITRO-VINYL)-PHENOL

2-METHOXY-4-(2-NITROVINYL)PHENOL

4-HYDROXY-3-METHOXYNITROSTYRENE

TRANS-4-HYDROXY-3-METHOXY-BETA-NITROSTYRENE

TRANS-2-METHOXY-4-(2-NITROVINYL)PHENOL

1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROETHYLENE

trans-4-hydroxy-3-methoxy-β-nitrostyrene

trans-2-Methoxy-4-(2-nitrovinyl)phenol 98%

3-METHOXY-4-HYDROXY-BETA-NITROSTYRENE

4-HYDROXY-3-METHOXY-BETA-NITROSTYRENE, >95%

trans-4-Hydroxy-3-methoxy-beta-nitrostyrene 98%

2-Methoxy-4-[(E)-2-nitrovinyl]phenol98%

1-(2-Nitroethenyl)-3-methoxy-4-hydroxybenzene

2-Methoxy-4-(2-nitroethenyl)phenol

β-Nitro-3-methoxy-4-hydroxystyrene

2-Methoxy-4-[(E)-2-nitrovinyl]phenol 98%

trans-4-Hydroxy-3-methoxy-beta-nitrostyrene, 2-Hydroxy-5-[(E)-2-nitroethenyl]anisole

Phenol, 2-methoxy-4-(2-nitroethenyl)-

(E)-2-methoxy-4-(2-nitrovinyl)phenol

4-Hydroxy-3-methoxy-β-nitrostyrene

vanillalnitromethane

trans-4-Hydroxy-3-methoxy-β-nitrostyrene, CAS 6178-42-3

6178-42-3

CH3OC6H3CHCHNO2OH

C9H9NO8

Organic Building Blocks

Alkenes

Acyclic

Building Blocks

Acyclic

Alkenes

Bioactive Small Molecules

Building Blocks

Cell Biology

Chemical Synthesis

Organic Building Blocks

Ethanes/ethenes