ChemicalBook > CAS DataBase List > 5-Bromouracil
5-Bromouracil
- Product Name
- 5-Bromouracil
- CAS No.
- 51-20-7
- Chemical Name
- 5-Bromouracil
- Synonyms
- 5-bromopyrimidine-2,4(1H,3H)-dione;5-BROMOPYRIMIDINE-2,4-DIOL;5-BROMO-1H-PYRIMIDINE-2,4-DIONE;5-Bromo-1,2,3,4-tetrahydropyrimidine-2,4-dione;5-BrUra;BROMOURACIL;5-Bromuracil;5-BROMOURACIL;5-bromo-uraci;BROMOURACIL, 5-
- CBNumber
- CB6388195
- Molecular Formula
- C4H3BrN2O2
- Formula Weight
- 190.98
- MOL File
- 51-20-7.mol
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5-Bromouracil Property
- Melting point:
- >300 °C (lit.)
- Density
- 1.8710 (rough estimate)
- refractive index
- 1.6200 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- <1g/l
- form
- Solid
- pka
- 6.77±0.10(Predicted)
- color
- White
- Water Solubility
- SOLUBLE IN COLD WATER
- Merck
- 14,1445
- BRN
- 127176
- InChIKey
- LQLQRFGHAALLLE-UHFFFAOYSA-N
- CAS DataBase Reference
- 51-20-7(CAS DataBase Reference)
- NIST Chemistry Reference
- 5-Bromouracil(51-20-7)
- EPA Substance Registry System
- 5-Bromouracil (51-20-7)
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Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-46
- Safety Statements
- 36/37-53-45-24/25
- WGK Germany
- 3
- RTECS
- YQ9060000
- TSCA
- Yes
- HS Code
- 29335995
- Hazardous Substances Data
- 51-20-7(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H341Suspected of causing genetic defects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 852473
- Product name
- 5-Bromouracil
- Purity
- 98%
- Packaging
- 5g
- Price
- $45.3
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 852473
- Product name
- 5-Bromouracil
- Purity
- 98%
- Packaging
- 25g
- Price
- $85.1
- Updated
- 2024/03/01
TCI Chemical
- Product number
- B0665
- Product name
- 5-Bromouracil
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $120
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- A14799
- Product name
- 5-Bromouracil, 98+%
- Packaging
- 5g
- Price
- $19.65
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- A14799
- Product name
- 5-Bromouracil, 98+%
- Packaging
- 25g
- Price
- $56.65
- Updated
- 2024/03/01
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5-Bromouracil Chemical Properties,Usage,Production
Description
5-bromouracil (5-BU) is a uracil derivative, and its 5' position of the pyrimidine ring is halogenated. If 5-BU is incorporated into DNA in place of thymine, the tautomeric shift will occur, and the 5-BU will base pair with guanine. After the replication, an A-T to G-C transition occurs. Furthermore, the presence of 5-BU within DNA increases the sensitivity of the molecule to UV light. 5-BU is structurally similar to thymine. Therefore, it is considered a thymine analog and base-pairs normally with adenine. It is rarely present in its enol form, where its base pairs with guanine. 5-Bromouracil treats neoplasms in the form of its nucleoside, 5-bromo-2-deoxy-uridine[1-2].
Chemical Properties
Prisms from H 2 O.
Uses
A major chemical mutagen. Incorporates into DNA, altering base-pair sequencing by replacing thymine
Definition
ChEBI: A pyrimidine having keto groups at the 2- and 4-positions and a bromo group at the 5-position.
General Description
White powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
A halogenated amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Hazard
Moderately toxic, alters DNA by replacing thymine.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition 5-Bromouracil emits very toxic fumes of bromide ion and NOx.
Fire Hazard
Flash point data for 5-Bromouracil are not available, but 5-Bromouracil is probably combustible.
Safety Profile
Moderately toxic by intraperitoneal route. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of Brand NOx.
References
[1] Bhagavan, N. and C. Ha. “Chapter 21 – Structure and Properties of DNA.” (2015): 381-400.
[2] Shen, Chang-Hui. “Nucleic Acid-Based Cellular Activities.” Diagnostic Molecular Biology 25 1 (2019): 27-57.
5-Bromouracil Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromouracil manufacturers
Chongqing Zhihe Biopharmaceutical Co., Ltd.
- Product
- 5-Bromouracil 51-20-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- 99
- Supply Ability
- 20tons
- Release date
- 2024-02-06
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
- Product
- 5-Bromouracil 51-20-7
- Price
- US $0.00/KG
- Min. Order
- 100g
- Purity
- 98%+
- Supply Ability
- 100kg
- Release date
- 2021-05-14
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- 5-Bromouracil 51-20-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- ≥98.0%
- Supply Ability
- 100kg/month
- Release date
- 2021-09-28
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