L-Cystine

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Description References

Product Name: L-Cystine
CAS No.: 56-89-3
Chemical Name: L-Cystine
Synonyms: (H-CYS-OH)2;(CYS)2;l-cystin;-Cystine;1-cystine;Cystine CRS;Cystine acid;L-(-)-CYSTINE;L-CYSTINE BASE;(r-(r*,r*))-3,3’-dithiobis(2-aminopropanoicacid)
CBNumber: CB6394079
Molecular Formula: C6H12N2O4S2
Formula Weight: 240.3
MOL File: 56-89-3.mol

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L-Cystine Property

Melting point:: >240 °C (dec.) (lit.)
alpha: -224 º(c=2 in 1M HCl)
Boiling point:: 468.2±45.0 °C(Predicted)
Density: 1.68
refractive index: -222.5 ° (C=1, 1mol/L HCl)
storage temp.: 2-8°C
solubility: 1 M HCl: 100 mg/mL
form: Powder/Solid
pka: 1.0, 2.1, 8.02, 8.71(at 25℃)
color: White
optical activity: [α]20/D 219±5°, c = 1% in 1 M HCl
Water Solubility: 0.112 g/L (25 ºC)
Merck: 14,2782
BRN: 1728094
Stability:: Stable. Incompatible with strong oxidizing agents.
InChIKey: LEVWYRKDKASIDU-IMJSIDKUSA-N
LogP: 0.773 (est)
CAS DataBase Reference: 56-89-3(CAS DataBase Reference)
NIST Chemistry Reference: L-Cystine(56-89-3)
EPA Substance Registry System: L-Cystine (56-89-3)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36-24/25
RIDADR: 2811
WGK Germany: 3
RTECS: HA2690000
Hazard Note: Irritant
TSCA: Yes
PackingGroup: III
HS Code: 29309014

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SAB1305544
Product name: MONOCLONAL ANTI-NEPHRIN antibody produced in mouse
Purity: clone 174CT2.1.1, crude ascites, buffered aqueous solution
Packaging: 100μL
Price: $466
Updated: 2024/03/01

Sigma-Aldrich

Product number: 30200
Product name: L-Cystine
Purity: ≥99.7% (TLC)
Packaging: 25g
Price: $43.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 2470
Product name: L-Cystine - CAS 56-89-3 - Calbiochem
Packaging: 25G
Price: $77.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1161586
Product name: Cystine
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $519
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1.02836
Product name: L-Cystine
Purity: suitable for biopharmaceutical production FCC
Packaging: 1kg
Price: $305
Updated: 2024/03/01

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L-Cystine Chemical Properties,Usage,Production

Description

L-cystine (formula: (SCH2CH(NH2) CO2H)2), the L-form of cystine) is a covalently linked dimeric nonessential amino acid formed through the oxidation of cysteine. It is contained in many foods including eggs, meat, dairy products, and whole grains as well as in skin and hairs. L-cystine and L-methionine are the amino-acids required for wound healing and formation of epithelial tissue. It is able to stimulate the hematopoietic system and promote the formation of white and red blood cells. It can also be used as a component of parental and enteral nutrition. It can also be used for the treatment of dermatitis and protection of liver function. L-cystine is manufactured through the enzymatic conversion from DL-amino thiazoline carboxylic acid.

References

http://www.ajiaminoscience.com/products/manufactured_products/l-amino_acids/L-Cystine.aspx
https://pubchem.ncbi.nlm.nih.gov/compound/L-cystine#section=Pharmacology
https://en.wikipedia.org/wiki/Cystine

Chemical Properties

A white or almost white, crystalline powder, practically insoluble in water and in alcohol.

Uses

L-Cystine is used as an antioxidant, protecting tissues against radiation and pollution. It finds application in protein synthesis. It is required for utilization of vitamin B6 and is useful in healing burns and wounds. It is also is required by certain malignant cell lines in the culture medium as well as for the growth of certain micro-organisms. It is useful in the stimulation of hematopoietic system and promotes the formation of white and red blood cells. It is an active ingredient in medications used to treat dermatitis.

Uses

L-Cystine has been used in in vitro cystine solubility assay to identify potential drugs that influence cystine solubility. It is also used as a supplement of phosphate-buffered saline to slice and wash periprosthetic tissues.

Uses

L-Cystine is a non-essential amino acid for human development. L-Cystine is formed by the dimerization of two cysteines through the sulfur.

Definition

ChEBI: L-cystine is the L-enantiomer of the sulfur-containing amino acid cystine. It has a role as a flour treatment agent, a human metabolite, a Saccharomyces cerevisiae metabolite, a mouse metabolite and an EC 1.2.1.11 (aspartate-semialdehyde dehydrogenase) inhibitor. It is a cystine, a L-cysteine derivative and a non-proteinogenic L-alpha-amino acid. It is a conjugate acid of a L-cystine anion. It is an enantiomer of a D-cystine. It is a tautomer of a L-cystine zwitterion.

General Description

This Standard Reference Material (SRM) is intended primarily for use in validating microchemical procedures for the determination of carbon, hydrogen, nitrogen, and sulfur in organic matter. SRM 143d is pure crystalline cystine supplied in a 2 g unit size. For more information, please refer to the SDS and COA.

SRM 143D_cert SRM 143D _SDS

Biochem/physiol Actions

Cysteine is the source of disulfide linkages in proteins and has a role in sulfur transport. It undergoes rapid oxidation to form cystine at physiological pH. L-cystine is crucial for oxygen production and low density lipoprotein modification by arterial smooth muscle cells. It also has a role in the synthesis of glutathione.

Safety Profile

Low toxicity by ingestion. When heated to decomposition it emits toxic fumes of PO, and SOx

Purification Methods

Cystine disulfoxide impurity is removed by treating an aqueous suspension with H2S. The cystine is filtered off, washed with distilled water and dried at 100o under a vacuum over P2O5. Crystallise it by dissolving in 1.5M HCl, then adjusting to neutral pH with ammonia. Likely impurities are D-cystine, meso-cystine and tyrosine. Also purify it by dissolving it in 10% NH3 and adding gradually dilute AcOH until the point of precipitation and cooling slowly [Dughton & Harrison Acta Cryst 12 396, 402 1959.] Alternatively dissolve it in 6N NH4OH and evaporate it at room temperature for crystallisation to occur. [Chaney & Steinrauf Acta Cryst 30 711 1974, Beilstein 4 IV 3155.]

L-Cystine Preparation Products And Raw materials

Raw materials

KERATIN Boc-D-Tyr-OH Α-PROTEIN terylene Hydrolyzate L-Histidine DL-Serine Hydrochloric acid SILK Sodium hydroxide Industrial ammonia Activated carbon,decolor L(+)-Arginine Activated carbon N-CARBOBENZOXY-DL-LEUCINE Ethylenediaminetetraacetic acid

Preparation Products

Cilastatin DL-Cystine L-Cysteine monohydrochloride L-Cysteine L-Cysteine hydrochloride monohydrate

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View Lastest Price from L-Cystine manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: L-Cystine 56-89-3
Price: US $100.00-30.00/kg
Min. Order: 1kg
Purity: 99.3%
Supply Ability: 1 ton per week
Release date: 2024-04-10

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: L-Cystine 56-89-3
Price: US $5.00/kg
Min. Order: 1kg
Purity: 99.92%
Supply Ability: 50000tons
Release date: 2024-04-11

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: L-Cystine 56-89-3
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99.10%
Supply Ability: 50000kg
Release date: 2024-04-11

56-89-3, L-CystineRelated Search:

Dilauryl thiodipropionate Cyproterone acetate Tris(hydroxymethyl)aminomethane DL-Homocysteine L-Cysteine ALTRENOGEST β-Alanine Ethyl 2-(Chlorosulfonyl)acetate N-Acetyl-L-cysteine 6-Aminocaproic acid Citric acid Glycine Folic acid ACETYL-L-CYSTINE L-Cysteine monohydrochloride Ascoric Acid L-Tryptophan L-Leucine

(r-(r*,r*))-3,3’-dithiobis(2-aminopropanoicacid)

1-cystine

3,3’-dithiobis(2-amino-,(r-(r*,r*))-propanoicaci

3,3’-dithiobis(2-aminopropanoicacid)

3,3’-dithiobis-l-alanin

3,3'-Dithiobis(2-aminopropanoic acid)

3,3'-Dithiodialanine

Alanine, 3,3'-dithiobis-

Alanine, 3,3'-dithiodi-

alpha-Diamino-beta-dithiolactic acid

beta,beta’-diamino-beta,beta’-dicarboxydiethyldisulfide

Carbocysteine Impurity 3

L-Cystine in stock GMP Factory

Acetylcysteine Impurity 1（Acetylcysteine EP Impurity A）

Acetylcysteine Impurity A

beta,beta’-dithiodialanine

beta,beta'-Diamino-beta,beta'-dicarboxydiethyl disulfide

beta,beta'-Dithiobisalanine

beta,beta'-Dithiodialanine

Bis(beta-amino-beta-carboxyethyl) disulfide

bis(beta-amino-beta-carboxyethyl)disulfide

Cysteine disulfide

cysteinedisulfide

Cystin

Cystine acid

cystineacid

Dicysteine

Gelucystine (L form)

L-3,3’-Dithiodialanine

Nephrin

Oxidized L-cysteine

oxidizedl-cysteine

Propanoic acid, 3,3'-dithiobis(2-amino-, (R-(R*,R*))-

(R)-(-)-CYSTINE

(R,R)-(-)-CYSTINE

(R,R)-3,3'-DITHIOBIS(2-AMINOPROPIONIC ACID)

l-cysteinedisulfide

l-cystin

L-Dicystiene

BETA,BETA'-DITHIOBIS-A-AMINOPROPIONIC ACID

CYSTINE, L-

(CYS)2

(H-CYS-OH)2

H-L-CYSTINE

L(-)-3,3'-DITHIOBIS(2-AMINOPROPANOIC ACID)

L-(-)-CYSTINE

L-CYSTINE

L-CYSTINE extrapure

gelucystine

L-3, 31-dithiobis (2-aminopropanoic acid)

L-Cystinic acid

L-β,β'-Dithiobis(2-amino-pro-panoic acid)

L-Cystine, Metal binding, protein structure, antioxidant

(2R)-2-Amino-3-[(2R)-2-amino-3-hydroxy-3-oxopropyl]disulfanylpropanoic acid

L-(-)-3,3'-Dithiobis (2-aminopropionic acid)

3,3'-Dithiobis(L-alanine)

(2S,7S)-(-)-Cystine

L-CYSTINERESEARCH GRADE