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4-METHOXYPHENYLACETAMIDE

Product Name
4-METHOXYPHENYLACETAMIDE
CAS No.
6343-93-7
Chemical Name
4-METHOXYPHENYLACETAMIDE
Synonyms
Einecs 228-745-9;4-METHOXYPHENYLACETAMIDE;P-METHOXYPHENYLACETAMIDE;4-Methoxybenzeneacetamide;Benzeneacetamide, 4-methoxy-;PARA METHOXYPHENYL ACETAMIDE;PARA METHOXYL PHENYL ACETAMIDE;2-(4-METHOXY-PHENYL)-ACETAMIDE;2-hydroxybenzoic acid [(1R,3R,4S)-4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl] ester
CBNumber
CB6403610
Molecular Formula
C9H11NO2
Formula Weight
165.19
MOL File
6343-93-7.mol
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4-METHOXYPHENYLACETAMIDE Property

Melting point:
182-184°C
Boiling point:
354.7±25.0 °C(Predicted)
Density 
1.123±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
16.37±0.40(Predicted)
color 
White to Off-White
BRN 
2088040
CAS DataBase Reference
6343-93-7(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
HS Code 
2924297099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S580813
Product name
2-(4-METHOXYPHENYL)ACETAMIDE
Purity
Aldrich<sup>CPR</sup>
Packaging
1 unit
Price
$185
Updated
2025/07/31
Sigma-Aldrich
Product number
S580813
Product name
2-(4-METHOXYPHENYL)ACETAMIDE
Purity
Aldrich
Packaging
1g
Price
$179
Updated
2024/03/01
TRC
Product number
M220175
Product name
4-Methoxyphenylacetamide
Packaging
100mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
2762AL
Product name
4-Methoxyphenylacetamide
Packaging
1g
Price
$81
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0011947
Product name
4-METHOXYPHENYLACETAMIDE
Purity
95.00%
Packaging
25G
Price
$1643.28
Updated
2021/12/16
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4-METHOXYPHENYLACETAMIDE Chemical Properties,Usage,Production

Uses

4-Methoxyphenylacetamide is a useful reagent in the preparation of novel pyrrolidone-??based derivatives as potential p53-??MDM2 inhibitors for use as potential antitumor agents.

Synthesis

104-47-2

6343-93-7

General procedure for the synthesis of 4-methoxybenzeneacetamide from p-methoxybenzeneacetonitrile: Ni NPs/HT catalyst (0.05 g) was added to a thick-walled pressure tube, followed by water (4 ml) and p-methoxybenzeneacetonitrile (1 mmol). The reaction mixture was placed in an oil bath at 120 °C and stirred vigorously. The reaction process was monitored by TLC analysis. Upon completion of the reaction, the reaction mixture was extracted with ethyl acetate and subsequently filtered to remove the catalyst. The filtrate was cooled to 0 °C to allow white crystals to precipitate. The crystalline product was collected by simple filtration and dried under vacuum at room temperature to give analytically pure 4-methoxyphenylacetamide. If the product did not precipitate, the reaction mixture was extracted with ethyl acetate followed by purification by silica gel column chromatography to finally obtain 4-methoxyphenylacetamide.

References

[1] Synthesis, 1989, # 12, p. 949 - 951
[2] RSC Advances, 2015, vol. 5, # 9, p. 6365 - 6371
[3] Zeitschrift fur Chemie, 1980, vol. 20, # 10, p. 380 - 380
[4] Catalysis Communications, 2012, vol. 29, p. 109 - 113
[5] Green Chemistry, 2014, vol. 16, # 4, p. 2136 - 2141

4-METHOXYPHENYLACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-METHOXYPHENYLACETAMIDE Suppliers

China 51 Germany 2 India 3 Switzerland 1 United Kingdom 7 United States 12 Global 76
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6343-93-7, 4-METHOXYPHENYLACETAMIDERelated Search:

(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE oxyphenisatine di(acetate) S(-)-ATENOLOL Atenolol (4-BUTOXYPHENYL)ACETAMIDE 2-[4-(2,3-EPOXYPROPOXY)PHENYL]ACETAMIDE Bufexamac ETHYL 3-HYDROXY-4,6-DIMETHOXY-2-OXOINDOLINE-3-CARBOXYLATE 3,4-DIMETHOXYPHENYLACETIC ACID HYDRAZIDE 4-Acetylamino-2-(diethylamino)anisole 4-Acetylamino-2-(bis(2-hydroxyethyl)amino)anisole 2',5'-DIMETHOXYACETANILIDE 4'-(Difluoromethoxy)acetanilide N-[3-[(2-Cyanoethyl)ethylamino]-4-methoxyphenyl]acetamide N-[3-[(2-Cyanoethyl)amino]-4-methoxyphenyl]acetamide 4-Acetylamino-2-(diallylamino)anisole 3'-Amino-4'-methoxyacetanilide 3-(N,N-Diacetoxyethyl)amino-4-methoxyacetanilide

  • Benzeneacetamide, 4-methoxy-
  • 2-(4-METHOXY-PHENYL)-ACETAMIDE
  • 4-METHOXYPHENYLACETAMIDE
  • PARA METHOXYL PHENYL ACETAMIDE
  • PARA METHOXYPHENYL ACETAMIDE
  • P-METHOXYPHENYLACETAMIDE
  • 4-Methoxybenzeneacetamide
  • Einecs 228-745-9
  • 2-hydroxybenzoic acid [(1R,3R,4S)-4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl] ester
  • 6343-93-7
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts