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Meglumine

Product Name
Meglumine
CAS No.
6284-40-8
Chemical Name
Meglumine
Synonyms
N-METHYL-D-GLUCAMINE;N-METHYLGLUCAMINE;Meglumin;Methylglucamine;1-deoxy-1-(methylamino)-d-glucito;MeguMine;Meglumine CRS;Methylglucamin;D(-)-N-METHYLGLUCAMINE;1-DEOXY-1-(METHYLAMINO)-D-GLUCITOL
CBNumber
CB6411710
Molecular Formula
C7H17NO5
Formula Weight
195.21
MOL File
6284-40-8.mol
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Meglumine Property

Melting point:
129-131.5 °C (lit.)
alpha 
-16.5 º (c=10, H2O, on dry sub)
Boiling point:
331.88°C (rough estimate)
Density 
1.2669 (rough estimate)
refractive index 
-16.5 ° (C=2, H2O)
RTECS 
LZ4295770
storage temp. 
2-8°C
solubility 
H2O: 0.1 g/mL, clear, colorless
form 
Crystalline Powder
pka
pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate)
color 
White to almost white
PH
11 (10g/l, H2O, 20℃)
optical activity
[α]20/D 16.5±0.5°, c = 2% in H2O
Water Solubility 
100 g/100 mL (25 ºC)
Sensitive 
Air Sensitive & Hygroscopic
Merck 
14,6078
BRN 
385906
InChIKey
MBBZMMPHUWSWHV-VZFHVOOUSA-N
LogP
-3.370 (est)
NIST Chemistry Reference
N-methylglucamine(6284-40-8)
EPA Substance Registry System
Meglumine (6284-40-8)
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Safety

Risk Statements 
36/37/38
Safety Statements 
24/25
WGK Germany 
3
F 
3-10-23
Autoignition Temperature
~662 °F
TSCA 
Yes
HS Code 
29221980
Toxicity
LD50 orally in Rabbit: > 5000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
66930
Product name
N-Methyl-D-glucamine
Purity
ReagentPlus , ≥99.0% (T)
Packaging
100g
Price
$67.8
Updated
2024/03/01
Sigma-Aldrich
Product number
8.18318
Product name
D(-)-N-Methylglucamine
Purity
for resolution of racemates for synthesis
Packaging
250g
Price
$72.3
Updated
2024/03/01
Sigma-Aldrich
Product number
1379140
Product name
Meglumine
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
1.06143
Product name
Meglumine
Purity
low in endotoxins, EMPROVE? API, Ph. Eur., ChP, JP, USP
Packaging
1KG
Price
$244
Updated
2022/05/15
Sigma-Aldrich
Product number
1.06187
Product name
Meglumine
Purity
EMPROVE? ESSENTIAL, Ph. Eur., ChP, JP, USP
Packaging
1KG
Price
$244
Updated
2022/05/15
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Meglumine Chemical Properties,Usage,Production

Chemical Properties

white to almost white crystalline powder

Chemical Properties

Meglumine occurs as a white to slightly yellow-colored crystalline powder; it is odorless or with a slight odor.

Uses

antiinflammatory

Uses

excipient in cosmetics and X-ray contrast media

Uses

N-Methyl-D-glucamine is used in conjunction with iodinated organic compounds in contrast media viz. diatrizoate meglumine and iodipamide meglumine. It is useful in ion-exchange resins to chelate boron ions selectively. It is also used as an excipient in pharmaceuticals, in cosmetics and X-ray contrast media. It is also employed in the synthesis of surface active agents, pharmaceuticals and dyes.

Production Methods

Meglumine is prepared by the imination of glucose and monomethylamine, in an alcoholic solution, followed by catalytic hydrogenation.

Definition

ChEBI: A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, whi e its antimonate is used as an antiprotozoal in the treatment of leishmaniasis.

brand name

Renovue (Bracco).

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Meglumine is a glucose-derived secondary amine which is widely used as an excipient in pharmaceutical formulations.

Pharmaceutical Applications

Meglumine is an organic base used as a pH-adjusting agent and solubilizing agent, primarily in the preparation of soluble salts of iodinated organic acids used as X-ray contrast media.

Safety

Meglumine is widely used in parenteral pharmaceutical formulations and is generally regarded as a nontoxic material at the levels usually employed as an excipient.
LD50 (mouse, IP): 1.68 g/kg

storage

Meglumine does not polymerize or dehydrate unless heated above 150°C for prolonged periods.
The bulk material should be stored in a well-closed container in a cool, dry place. Meglumine should not be stored in aluminum containers since it reacts to evolve hydrogen gas; it discolors if stored in containers made from copper or copper alloys. Stainless steel containers are recommended.

Purification Methods

Crystallise N-methyl-D(-)-glucamine from MeOH. Its solubility in H2O is 10%. [Karrer & Herkenrath Helv Chim Acta 20 83 1957 also for other N-alkyl derivatives, Beilstein 4 IV 1914.]

Incompatibilities

Incompatible with aluminum, copper, mineral acids, and oxidizing materials. Differential scanning calorimetry studies suggest meglumine is incompatible with glipizide.

Regulatory Status

Included in the FDA Inactive Ingredients Database (injections; oral tablets). Included in parenteral medicines licensed in the UK.

Meglumine Preparation Products And Raw materials

Raw materials

weak 1-Glucose-methylamine schiffbase ACETALDEHYDE AMMONIA

Preparation Products

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Meglumine Suppliers

Americas 1 Belgium 3 Brazil 1 Canada 1 China 558 Czech Republic 1 Europe 4 Germany 11 India 39 Japan 6 Mexico 1 Poland 1 Russia 1 South Korea 2 Spain 1 Switzerland 4 The Netherlands 1 United Kingdom 21 United States 64 Global 721
Carbosynth
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Long-Range Europe Limited
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Discovery Fine Chemicals Ltd.
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Molekula Limited
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Cenik Chemicals
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Melrob Ltd (part of Nordmann)
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Fisher Scientific Uk Ltd.
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Manchester Organics
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Fluorochem Ltd
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View Lastest Price from Meglumine manufacturers

HebeiShuoshengImportandExportco.,Ltd
Product
Meglumine 6284-40-8
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-06
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Meglumine 6284-40-8
Price
US $75.00-20.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-30
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Meglumine 6284-40-8
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
500kgs
Release date
2021-09-29

6284-40-8, MeglumineRelated Search:

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  • 1-deoxy-1-(methylamino)-d-glucito
  • 1-Deoxy-1-(methylamino)hexitol
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  • Fosaprepitant Impurity H
  • C7H18NO5
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  • methyl-[(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]ammonium
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