2,2',5,5'-Tetrachlorobenzidine
- Product Name
- 2,2',5,5'-Tetrachlorobenzidine
- CAS No.
- 15721-02-5
- Chemical Name
- 2,2',5,5'-Tetrachlorobenzidine
- Synonyms
- TCB;PK3;OIP3;PKM1 active human;2,2',5,5'-Tetrachlor;2,2’,5,5’-tetrachloro-benzidin;3,3’,6,6’-tetrachlorobenzidine;2,2',5,5'-tetrachlorobenzidine;2,2,5,5-TETRACHLOROBENZIDINE 98+%;Benzidine, 2,2',5,5'-tetrachloro-
- CBNumber
- CB6411730
- Molecular Formula
- C12H8Cl4N2
- Formula Weight
- 322.02
- MOL File
- 15721-02-5.mol
2,2',5,5'-Tetrachlorobenzidine Property
- Melting point:
- 135-140 °C(lit.)
- Boiling point:
- 477.67°C (rough estimate)
- Density
- 1.5309 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- -70°C
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 1.58±0.13(Predicted)
- color
- Light yellow to Yellow to Orange
- biological source
- human
- Water Solubility
- water: soluble
- CAS DataBase Reference
- 15721-02-5(CAS DataBase Reference)
- IARC
- 3 (Vol. 27, Sup 7) 1987
- EPA Substance Registry System
- [1,1'-Biphenyl]-4,4'-diamine, 2,2',5,5'-tetrachloro- (15721-02-5)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SRP0415
- Product name
- PKM1 active human
- Purity
- recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
- Packaging
- 20μG
- Price
- $653
- Updated
- 2024/03/01
- Product number
- T0933
- Product name
- 2,2',5,5'-Tetrachlorobenzidine
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 25g
- Price
- $70
- Updated
- 2024/03/01
- Product number
- T0933
- Product name
- 2,2',5,5'-Tetrachlorobenzidine
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 500g
- Price
- $576
- Updated
- 2024/03/01
- Product number
- T204568
- Product name
- 2,2'',5,5''-Tetrachlorobenzidine
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- T204568
- Product name
- 2,2'',5,5''-Tetrachlorobenzidine
- Packaging
- 2.5g
- Price
- $75
- Updated
- 2021/12/16
2,2',5,5'-Tetrachlorobenzidine Chemical Properties,Usage,Production
Uses
PKM1active human has been used in:
- cell-based kinase assay to study the ability of a compound to inhibit the kinase activity of PKM1.
- oxidative stress experiments on PKM2.
- Co-immunoprecipitation (Co-IP) to determine pyruvate kinase M2 (PKM2) as a novel direct binding partner of phosphoserine aminotransferase 1 (PSAT1).
Definition
ChEBI: 2,2',5,5'-Tetrachlorobenzidine is a member of biphenyls and a dichlorobenzene.
Production Methods
2,2' ,5,5' -Tetrachlorobenzidine is made by the reduction of 2,5-dichloronitrobenzene with zinc dust and sodium hydroxide solution. The subsequent rearrangement is carried out using sulfuric acid or hydrochloric acid. The dihydrochloride melts at 230 ℃. Tetrachlorobenzidine is marketed as the free base and is used to produce yellow pigments.
Biological Activity
Pyruvate kinase (PK) catalyzes the dephosphorylation of phosphoenolpyruvate(PEP) into pyruvate. It is also involved in glycolysis by releasing ATP.Allosteric effects and intracellular signal transduction regulate the enzymaticactivity of PKM1. PKM1 is involved in several biological processes such asmetabolic reprogramming, and innate and acquired immune response. Itparticipates in protein interactions, protein synthesis, glycolysis, andintranuclear signal transduction.
Safety Profile
Suspected carcinogen with experimental carcinogenic and tumorigenic data. When heated to decomposition it emits very toxic fumes of NO, and Cl-.
2,2',5,5'-Tetrachlorobenzidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,2',5,5'-Tetrachlorobenzidine manufacturers
- Product
- 2,2',5,5'-Tetrachlorobenzidine 15721-02-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2024-08-21
- Product
- 2,2',5,5'-Tetrachlorobenzidine 15721-02-5
- Price
- US $10.00-7.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 20ton
- Release date
- 2024-06-05
- Product
- 2,2',5,5'-Tetrachlorobenzidine 15721-02-5
- Price
- US $8.00-2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-24