Ethyl diethoxyphosphinylformate

Product Name: Ethyl diethoxyphosphinylformate
CAS No.: 1474-78-8
Chemical Name: Ethyl diethoxyphosphinylformate
Synonyms: Foscarnet EP Impurity D;Foscarate EP Impurity D;Foscarnet impurity D CRS;TRIETHYL PHOSPHONOFORMATE;Triethyl carboxyphosphonate;Triethyl phosphonomethanoate;Foscarnet Related CoMpound D;Diethyl carbethoxyphosphonate;TRIETHYL PHOSPHONOFORMATE 98%;Foscarnet Sodium EP Impurity D
CBNumber: CB6423762
Molecular Formula: C7H15O5P
Formula Weight: 210.16
MOL File: 1474-78-8.mol

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Ethyl diethoxyphosphinylformate Property

Boiling point:: 135 °C12 mm Hg(lit.)
Density: 1.11 g/mL at 25 °C(lit.)
refractive index: n20/D 1.423(lit.)
Flash point:: >230 °F
storage temp.: Store below +30°C.
solubility: Chloroform (Slightly), Methanol (Slightly)
color: Colorless to Almost colorless
Specific Gravity: 1.11
BRN: 1781949
Stability:: Moisture Sensitive
CAS DataBase Reference: 1474-78-8(CAS DataBase Reference)
NIST Chemistry Reference: Phosphinecarboxylic acid, diethoxy-, ethyl ester, oxide(1474-78-8)
EPA Substance Registry System: Phosphinecarboxylic acid, diethoxy-, ethyl ester, oxide (1474-78-8)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-43
Safety Statements: 24/25-36/37-26-37-24
WGK Germany: 3
TSCA: Yes
HS Code: 2931 39 90

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2870
Product name: Foscarnet Related Compound D
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 0.5ML
Price: $634
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1283324
Product name: Foscarnet Related Compound D
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 0.27ml
Price: $1140
Updated: 2024/03/01

TCI Chemical

Product number: E0400
Product name: Ethyl Diethoxyphosphinylformate
Packaging: 25g
Price: $40
Updated: 2024/03/01

Alfa Aesar

Product number: B23367
Product name: Ethyl diethoxyphosphinylformate, 97+%
Packaging: 100g
Price: $46.4
Updated: 2021/12/16

Alfa Aesar

Product number: B23367
Product name: Ethyl diethoxyphosphinylformate, 97+%
Packaging: 25g
Price: $16.7
Updated: 2021/12/16

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Ethyl diethoxyphosphinylformate Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to slightly yellow liquid

Uses

Diethyl (Ethoxycarbonyl)phosphonate is an impurity in the synthesis of Foscarnet (F727400), an inhibitor of viral DNA polymerase and reverse transcriptase. Foscarnet is used as an antiviral.

General Description

for synthesis

Purification Methods

Dissolve it in Et2O, shake this with H2O (to remove any trace of NaCl impurity), dry (Na2SO4), evaporate and distil it using an efficient fractionating column. [Nylén Chem Ber 57 1035 1924, Reetz et al. J Am Chem Soc 77 3813 1955, Monson Advanced Organic Synthesis Academic Press p 89 1972, Beilstein 3 II 103.]

Ethyl diethoxyphosphinylformate Preparation Products And Raw materials

Raw materials

Preparation Products

Foscarnet sodium

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Ethyl diethoxyphosphinylformate Suppliers

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View Lastest Price from Ethyl diethoxyphosphinylformate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Ethyl diethoxyphosphinylformate 1474-78-8
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2024-07-26

Shaanxi Dideu Medichem Co. Ltd

Product: Triethyl Phosphonoformate 1474-78-8
Price: US $1.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 tons
Release date: 2020-01-14

Career Henan Chemical Co

Product: Ethyl diethoxyphosphinylformate 1474-78-8
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 500kg
Release date: 2019-12-31

1474-78-8, Ethyl diethoxyphosphinylformateRelated Search:

Tripropyl orthoformate Methyldiethoxyphosphine ETHYL METHYLPHOSPHINATE TRIMETHYL PHOSPHONOFORMATE Diethyl (hydroxymethyl)phosphonate Foscarnet ETHYL METHYLPHOSPHONIC ACID METHYLPHOSPHONIC ACID Ethyl diethoxyphosphinylformate Diethyl methylphosphonate METHOXY CARBONYL PHOSPHONIC ACID PhosphonoMethanol METHYL METHYLPHOSPHONIC ACID Dimethyl methylphosphonate Dimethyl hydroxymethylphosphonate

Diethyl carbethoxyphosphonate

Diethyl ethoxycarbonylphosphonate

Ethyl diethoxyphosphinecarboxylate oxide

Formic acid, phosphono-, triethyl ester

phosphinecarboxylicacid,diethoxy-,ethylester,oxide

Triethyl carboxyphosphonate

Triethyl phosphonomethanoate

(ETHOXYCARBONYL)PHOSPHONIC ACID DIETHYL ESTER

ETHYL DIETHOXYPHOSPHINYLFORMATE

DIETHOXYPHOSPHINYLFORMIC ACID ETHYL ESTER

TRIETHYL PHOSPHONOFORMATE

TRIETHYL PHOSPHONOFORMATE 98%

PhosphonoformicacidTriethylester

Foscarnet Sodium EP Impurity D

Foscarnet Sodium Impurity 4（Foscarnet Sodium EP Impurity D）

Ethyl diethoxyphosphinylformate,98%

TRIETHYL PHOSPHONOFORMATE (ETHYL DIETHOXYPHOSPHINILFORMATE)

ethyl diethyl-phosphonoformate

ETHYL DIETHOXYPHOSPHINYLFORMATE (TRIETHYL PHOSPHONOFORMATE)

Foscarnet Related Compound D (0.27 mL) (O,O-diethyl ethoxycarbonylphosphonate)

Diethoxyphosphinylformic Acid Ethyl Ester (Ethoxycarbonyl)phosphonic Acid Diethyl Ester Triethyl Phosphonoformate

Foscarnet Related CoMpound D

Ethyl diethoxyphospinylformate

Foscarnet impurity D CRS

Foscarnet EP Impurity D

Phosphinecarboxylic acid, 1,1-diethoxy-, ethyl ester, 1-oxide

Foscarnet Related Compound D (O,O-diethyl ethoxycarbonylphosphonate) (1283324)

Foscarnet USP Related Compound D

Foscarnet Sodium Hexahydrate Impurity D

Foscarnet Sodium Hexahydrate EP Impurity D

Foscarnet Sodium EP Impurity D (Foscarnet USP Related Compound D)

Foscarate EP Impurity D

1474-78-8

C2H5O2POCOOC2H5

C7H15O5P

Building Blocks

Phosphorus Compounds

Phosphonates/Phosphinates

Organic Building Blocks

Phosphonates/Phosphinates

Phosphorus Compounds