3-Methyl-2-nitroaniline
- Product Name
- 3-Methyl-2-nitroaniline
- CAS No.
- 601-87-6
- Chemical Name
- 3-Methyl-2-nitroaniline
- Synonyms
- 2-NITRO-M-TOLUIDINE;3-AMINO-2-NITROTOLUENE;3-METHYL-2-NITROANILINE;2-NITRO-3-METHYL ANILINE;3-Methyl-2-nitrobenzenamine;3-Methyl-2-nitroaniline 97%;3-Methyl-2-nitro-phenylamine;Benzenamine,3-methyl-2-nitro-;3-Amino-2-nitrotoluene 10 μg/mL in Acetonitrile;3-Amino-2-nitrotoluene, 2-Amino-6-methylnitrobenzene
- CBNumber
- CB6432197
- Molecular Formula
- C7H8N2O2
- Formula Weight
- 152.15
- MOL File
- 601-87-6.mol
3-Methyl-2-nitroaniline Property
- Melting point:
- 107-108 °C
- Boiling point:
- 288.6±20.0 °C(Predicted)
- Density
- 1.269±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- crystalline powder
- pka
- -0.11±0.10(Predicted)
- color
- Orange
- InChI
- InChI=1S/C7H8N2O2/c1-5-3-2-4-6(8)7(5)9(10)11/h2-4H,8H2,1H3
- InChIKey
- VDCZKCIEXGXCDJ-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=CC(C)=C1[N+]([O-])=O
Safety
- HS Code
- 2921420090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 074328
- Product name
- 3-Methyl-2-nitroaniline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $22
- Updated
- 2021/12/16
- Product number
- 4755-1-X5
- Product name
- 3-Methyl-2-nitroaniline
- Purity
- 97%
- Packaging
- 1g
- Price
- $32
- Updated
- 2021/12/16
- Product number
- 074328
- Product name
- 3-Methyl-2-nitroaniline
- Purity
- 95+%
- Packaging
- 5g
- Price
- $59
- Updated
- 2021/12/16
- Product number
- FA152737
- Product name
- 3-Amino-2-nitrotoluene
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- W7280
- Product name
- 3-Methyl-2-nitroaniline
- Packaging
- 1g
- Price
- $79
- Updated
- 2021/12/16
3-Methyl-2-nitroaniline Chemical Properties,Usage,Production
Uses
3-Methyl-2-nitroaniline is used in the purification of 2-Methoxy-5-trifluoromethoxybenzaldehyde. It also an important component in preparing benzimidazoles. It is used in palladium-catalyzed synthesis of quinoxline deriitives.
Synthesis
60310-07-8
601-87-6
General procedure for the synthesis of 3-methyl-2-nitroaniline from 3-methyl-2-nitrobenzamide: NaOH (2.220 g, 55.5 mmol) was dissolved in water (12 mL) at 0°C, followed by the addition of Br2 (0.322 mL, 6.26 mmol). Next, 3-methyl-2-nitrobenzamide (1 g, 5.55 mmol) was added all at once and the mixture was slowly heated in a water bath to 50-55°C (internal temperature), at which point oil droplets were observed to separate. The temperature was continued to be gradually increased to 70°C and maintained at this temperature for 1 hour. Subsequently, a solution of NaOH (0.7 g) dissolved in water (4 mL) was added and the temperature was slowly raised to 80°C and held for another 1 hour. After completion of the reaction, it was cooled to room temperature and extracted with EtOAc (3x50mL). The organic layers were combined, dried and concentrated to give 0.7 g (90% yield) of the target compound 3-methyl-2-nitroaniline.LC-MS analysis showed m/z of 153.1 (M + H)+ and retention time of 1.65 min.
References
[1] Patent: WO2015/92713, 2015, A1. Location in patent: Page/Page column 73; 74
[2] Patent: WO2016/203400, 2016, A1. Location in patent: Page/Page column 49
[3] Patent: WO2016/203401, 2016, A1. Location in patent: Page/Page column 60; 61
[4] Patent: WO2016/202253, 2016, A1. Location in patent: Page/Page column 126; 127
[5] Patent: WO2018/104766, 2018, A1. Location in patent: Page/Page column 60-61
3-Methyl-2-nitroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Methyl-2-nitroaniline manufacturers
- Product
- 3-Methyl-2-nitroaniline 601-87-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.1%
- Supply Ability
- 100 tons
- Release date
- 2022-02-20
- Product
- 3-Methyl-2-nitroaniline 601-87-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-26