METHYL 3-HYDROXY-1-METHYLPYRAZOLE-5-CARBOXYLATE
- Product Name
- METHYL 3-HYDROXY-1-METHYLPYRAZOLE-5-CARBOXYLATE
- CAS No.
- 52867-42-2
- Chemical Name
- METHYL 3-HYDROXY-1-METHYLPYRAZOLE-5-CARBOXYLATE
- Synonyms
- Methyl 3-Hydroxy-1-Methyl-1H-Pyrazole-5-Carboxylate;Methyl 3-hydroxy-1-Methylpyrazole;METHYL 3-HYDROXY-1-METHYLPYRAZOLE-5-CARBOXYL;METHYL 3-HYDROXY-1-METHYLPYRAZOLE-5-CARBOXYLATE;methyl 2-methyl-5-oxo-1H-pyrazole-3-carboxylate;Methyl 3-hydroxy-1-Methyl-1H-pyrazole-4-carboxylate;Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate;5-hydroxy-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester;Methyl 3-Hydroxy-1-Methyl-1H-Pyrazole-5-Carboxylate(WXC00843);2,5-Dihydro-2-methyl-5-oxo-1H-pyrazole-3-carboxylic acid methyl ester
- CBNumber
- CB6451242
- Molecular Formula
- C6H8N2O3
- Formula Weight
- 156.14
- MOL File
- 52867-42-2.mol
METHYL 3-HYDROXY-1-METHYLPYRAZOLE-5-CARBOXYLATE Property
- Melting point:
- 197 °C(Solv: methanol (67-56-1))
- Density
- 1.288±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 7.68±0.70(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B587665
- Product name
- methyl3-hydroxy-1-methyl-1H-pyrazole-5-carboxylate
- Packaging
- 100mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- 121971
- Product name
- Methyl3-hydroxy-1-methyl-1H-pyrazole-5-carboxylate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $393
- Updated
- 2021/12/16
- Product number
- 7480AB
- Product name
- Methyl2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate
- Packaging
- 1g
- Price
- $439
- Updated
- 2021/12/16
- Product number
- CHM0152036
- Product name
- METHYL 3-HYDROXY-1-METHYLPYRAZOLE-5-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.42
- Updated
- 2021/12/16
- Product number
- 121971
- Product name
- Methyl3-hydroxy-1-methyl-1H-pyrazole-5-carboxylate
- Purity
- >95%
- Packaging
- 1g
- Price
- $532
- Updated
- 2021/12/16
METHYL 3-HYDROXY-1-METHYLPYRAZOLE-5-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
302-15-8
762-42-5
52867-42-2
Step I: Synthesis of methyl 3-hydroxy-1-methyl-1H-pyrazole-5-carboxylate (3_41_2) Triethylamine (66 mL, 474.4 mmol) was added to a mixed solution of methylhydrazine sulfate (30.4 g, 211 mmol) in water (150 mL) and methanol (300 mL). The reaction mixture was stirred at room temperature for 0.5 h. Dimethyl butynedioate (30 g, 211 mmol) was subsequently added. The reaction system was warmed up to 70 °C with continuous stirring for 18 hours. After completion of the reaction, the mixture was allowed to stand at room temperature for two days, the precipitated solid was collected by filtration and dried to give 12 g of the target product. The filtrate was concentrated, cooled in an ice bath and filtered again to collect the solids and dried to give an additional 5 g of the target product 3_41_2 (total 17 g, 52% yield) as a yellow solid. NMR (400 MHz, DMSO-d6): δ = 3.79 (s, 3H), 3.88 (s, 3H), 6.01 (s, 1H), 10.05 (s, 1H).
References
[1] Patent: WO2013/110643, 2013, A1. Location in patent: Paragraph 00351; 00352
[2] Patent: US2018/170909, 2018, A1. Location in patent: Paragraph 1891; 1892
[3] Patent: WO2015/50989, 2015, A2. Location in patent: Paragraph 00299; 00300
METHYL 3-HYDROXY-1-METHYLPYRAZOLE-5-CARBOXYLATE Preparation Products And Raw materials
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