2-IODOPHENYLACETONITRILE
- Product Name
- 2-IODOPHENYLACETONITRILE
- CAS No.
- 40400-15-5
- Chemical Name
- 2-IODOPHENYLACETONITRILE
- Synonyms
- o-Iodobenzyl cyanide;2-IODOBENZYL CYANIDE;2-IODOPHENYLACETONITRILE;O-IODOPHENYLACETONITRILE;2-Iodobenzeneacetonitrile;2-iodo-2-phenylacetonitrile;Benzeneacetonitrile, 2-iodo-;2-Iodophenylacetonitrile 97%;2-(2-iodophenyl)acetonitrile;2-Iodophenylacetonitrile,96%
- CBNumber
- CB6453473
- Molecular Formula
- C8H6IN
- Formula Weight
- 243.04
- MOL File
- 40400-15-5.mol
2-IODOPHENYLACETONITRILE Property
- Boiling point:
- 113-120 °C0.5 mm Hg(lit.)
- Density
- 1.75 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.618(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Appearance
- White to light yellow Solid
- Sensitive
- Light Sensitive
- BRN
- 2083106
- CAS DataBase Reference
- 40400-15-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 23-26-36
- RIDADR
- 3276
- WGK Germany
- 3
- HazardClass
- 6.1
- PackingGroup
- III
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 531464
- Product name
- 2-Iodophenylacetonitrile
- Purity
- 97%
- Packaging
- 10g
- Price
- $209
- Updated
- 2023/06/20
- Product number
- I737295
- Product name
- 2-IodobenzylCyanide
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- J95205
- Product name
- 2-Iodobenzylcyanide
- Packaging
- 5g
- Price
- $51
- Updated
- 2021/12/16
- Product number
- X2662
- Product name
- 2-Iodobenzylcyanide
- Packaging
- 5g
- Price
- $63.7
- Updated
- 2021/12/16
- Product number
- HCH0020093
- Product name
- 2-IODO BENZYL CYANIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $629.07
- Updated
- 2021/12/16
2-IODOPHENYLACETONITRILE Chemical Properties,Usage,Production
Uses
2-Iodophenylacetonitrile may be used in the preparation of:
- 2?-aminobiphen-2-ylacetonitrile
- ethyl (2-iodophenyl)iminoacetate hydrochloride
- 3,4-disubstituted 2-naphthalenamines
It may also be used in the preparation of the following nitriles:
- 2-(2-iodophenyl)-2-methylpropanenitrile
- 1-(2-iodophenyl)cyclopentanecarbonitrile
- 5-bromo-2-(2-iodophenyl)pentanenitrile
- 2-(2-iodophenyl)-2-propylpentanenitrile
- 1-(2-iodophenyl)cyclohexanecarbonitrile
- 1-(2-Iodophenyl)cyclopropanecarbonitrile
General Description
2-Iodophenylacetonitrile is a 2-aryl substituted nitrile. It reacts with lactams to form ring-fused isoquinolinones via palladium-catalyzed carboxamidation in tandem with aldol condensation.
Synthesis
3240-34-4
17729-59-8
40400-15-5
Distilled dichloromethane (5 mL) was added to a 25 mL reaction tube under nitrogen protection. Subsequently, 161 mg (0.5 mmol) of iodobenzene diacetate was added. Next, 180 μL of trimethylsilyl trifluoromethanesulfonate (TMSOTf, 1.0 mmol) was added. The reaction mixture was stirred at room temperature for 5 min. After that, 198 mg (0.6 mmol) of 2-(tributylstannyl)acetonitrile was added at -78 °C and stirring was continued for 5 min, and the reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, 3 mL of saturated sodium bicarbonate solution was added to quench the reaction. The reaction was slowly warmed to room temperature and then extracted with dichloromethane (3 mL x 3). The organic phases were combined and dried over anhydrous sodium sulfate. It was subsequently concentrated under reduced pressure. Purification by column chromatography (Rf = 0.19, unfolding agent: petroleum ether/ethyl acetate = 40/1, v/v) afforded the target product 2-iodophenylacetonitrile as a white solid in 86% yield.
References
[1] Angewandte Chemie - International Edition, 2018, vol. 57, # 29, p. 9078 - 9082
[2] Angew. Chem., 2018, vol. 130, # 29, p. 9216 - 9220,5
[3] Patent: CN108409602, 2018, A. Location in patent: Paragraph 0022; 0023; 0024
2-IODOPHENYLACETONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
2-IODOPHENYLACETONITRILE Suppliers
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 16075
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12984
- Advantage
- 57
- Tel
- sales@witofly.com
- Country
- China
- ProdList
- 2864
- Advantage
- 52
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 400-1166-196 13458535857
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 13350
- Advantage
- 58
- Tel
- 86-0531-68658065 15726150375
- Fax
- 0531-68658065
- 1071018499@qq.com
- Country
- China
- ProdList
- 526
- Advantage
- 58
View Lastest Price from 2-IODOPHENYLACETONITRILE manufacturers
- Product
- 2-IODOPHENYLACETONITRILE 40400-15-5
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02