2-IODOPHENYLACETONITRILE Property

Boiling point:

113-120 °C0.5 mm Hg(lit.)

Density 

1.75 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.618(lit.)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

Sensitive 

Light Sensitive

BRN 

2083106

CAS DataBase Reference

40400-15-5(CAS DataBase Reference)

Safety

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

23-26-36

RIDADR 

3276

WGK Germany 

3

HazardClass 

6.1

PackingGroup 

III

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

2-IODOPHENYLACETONITRILE Chemical Properties,Usage,Production

Uses

2-Iodophenylacetonitrile may be used in the preparation of:

• 2?-aminobiphen-2-ylacetonitrile
• ethyl (2-iodophenyl)iminoacetate hydrochloride
• 3,4-disubstituted 2-naphthalenamines

• 2-(2-iodophenyl)-2-methylpropanenitrile
• 1-(2-iodophenyl)cyclopentanecarbonitrile
• 5-bromo-2-(2-iodophenyl)pentanenitrile
• 2-(2-iodophenyl)-2-propylpentanenitrile
• 1-(2-iodophenyl)cyclohexanecarbonitrile
• 1-(2-Iodophenyl)cyclopropanecarbonitrile

General Description

2-Iodophenylacetonitrile is a 2-aryl substituted nitrile. It reacts with lactams to form ring-fused isoquinolinones via palladium-catalyzed carboxamidation in tandem with aldol condensation.