ChemicalBook > CAS DataBase List > 3-Methyl-8-quinolinesulphonyl chloride
3-Methyl-8-quinolinesulphonyl chloride
- Product Name
- 3-Methyl-8-quinolinesulphonyl chloride
- CAS No.
- 74863-82-4
- Chemical Name
- 3-Methyl-8-quinolinesulphonyl chloride
- Synonyms
- Argatroban Impurity 29;Argatraban Intermediate;Argatraban Intermediate -2;3-Methylquinoline-8-sulfonyl;8-CHLOROSULFONYL-3-METHYLQUINOLINE;3-METHYL-8-QUINOLINESULFONYL CHLORIDE;3-methylquinoline-3-sulfonyl chloride;8-Quinolinesulfonyl chloride, 3-methyl-;3-METHYL-8-QUINOLINE SULPHONYL CHLORIDE;3-methyl quinoline-8-sulphonyl chloride
- CBNumber
- CB6460864
- Molecular Formula
- C10H8ClNO2S
- Formula Weight
- 241.69
- MOL File
- 74863-82-4.mol
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3-Methyl-8-quinolinesulphonyl chloride Property
- Melting point:
- 158-159°C
- Boiling point:
- 371.5±27.0 °C(Predicted)
- Density
- 1.424±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly)
- form
- Solid
- pka
- 0.82±0.28(Predicted)
- color
- White to Pale Brown
- Stability:
- Moisture Sensitive - Store Under Inert Atmosphere
- InChI
- InChI=1S/C10H8ClNO2S/c1-7-5-8-3-2-4-9(15(11,13)14)10(8)12-6-7/h2-6H,1H3
- InChIKey
- XCMAYGDQKTWICK-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC=CC=2S(Cl)(=O)=O)C=C(C)C=1
- CAS DataBase Reference
- 74863-82-4(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
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N-Bromosuccinimide Price
TRC
- Product number
- M325967
- Product name
- 3-Methyl-8-quinolinesulfonylChloride
- Packaging
- 5g
- Price
- $220
- Updated
- 2021/12/16
AK Scientific
- Product number
- P808
- Product name
- 3-Methyl-8-quinolinesulphonylchloride
- Packaging
- 250mg
- Price
- $15
- Updated
- 2021/12/16
Frontier Specialty Chemicals
- Product number
- JK195326
- Product name
- 3-Methyl-8-quinolinesulfonylchloride
- Purity
- 98%
- Packaging
- 1g
- Price
- $309
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- CHM0010735
- Product name
- 3-METHYL-8-QUINOLINESULFONYL CHLORIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $692.46
- Updated
- 2021/12/16
Medical Isotopes, Inc.
- Product number
- 12205
- Product name
- 3-Methyl-8-quinolinesulfonylChloride
- Packaging
- 1g
- Price
- $875
- Updated
- 2021/12/16
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3-Methyl-8-quinolinesulphonyl chloride Chemical Properties,Usage,Production
Chemical Properties
Off-White to Pale Brown Solid
Uses
3-Methyl-8-quinolinesulfonyl Chloride (cas# 74863-82-4) is a compound useful in organic synthesis.
Synthesis
612-58-8
74863-82-4
The general procedure for the synthesis of 3-methylquinoline-8-sulfonyl chloride from 3-methylquinoline was as follows: 3-methylquinoline (5.2 g, 36 mmol) was slowly added to 9 mL (135 mmol) of chlorosulfonic acid at 0°C with reference to U.S. Patent Nos. 4,522,576 and 5,332,822. After removing the ice bath, the reaction mixture was stirred at 100 °C overnight. After the reaction mixture was cooled to room temperature, 3.3 mL (45 mmol) of thionyl chloride was added, followed by heating at 70 °C for 1 hour. Upon completion of the reaction, the mixture was cooled to 0 °C and carefully quenched with ice (note: this step is highly reactive). The reaction mixture was diluted with 100 mL of water and extracted with dichloromethane (100 mL). The organic phase was washed with water, dried over anhydrous magnesium sulfate and concentrated to give the crude product. The crude product was ground with a solvent mixture of dichloromethane/ether to give 1.58 g (18% yield) of 3-methylquinoline-8-sulfonyl chloride as a brown solid. The product was characterized by 1H-NMR (300 MHz, DMSO-d6): δ 9.17-9.29 (m, 2H), 8.32-8.38 (m, 2H), 7.96 (dd, 1H, J = 7Hz), and 2.51 (t, 3H, J = 2Hz).
References
[1] Patent: US6235778, 2001, B1
3-Methyl-8-quinolinesulphonyl chloride Preparation Products And Raw materials
Raw materials
Toluene
3-Methylquinoline
Chlorosulfonic acid
Phosphorus pentachloride
Diethyl ether
Dichloromethane
Thionyl chloride
Preparation Products
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View Lastest Price from 3-Methyl-8-quinolinesulphonyl chloride manufacturers
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- 3-Methyl-8-quinolinesulphonyl chloride 74863-82-4
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 500kg
- Release date
- 2021-10-20
Changzhou waston chemical technology Co.,Ltd
- Product
- 3-Methyl-8-quinolinesulphonyl chloride 74863-82-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 90%,97%
- Supply Ability
- As your request
- Release date
- 2025-03-19
Shaanxi Dideu Medichem Co. Ltd
- Product
- 3-Methyl-8-quinolinesulphonyl chloride 74863-82-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-19
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