ChemicalBook > CAS DataBase List > Glumetinib
Glumetinib
- Product Name
- Glumetinib
- CAS No.
- 1642581-63-2
- Chemical Name
- Glumetinib
- Synonyms
- SCC244;Glumetinib;Gumarontinib;GLUMETINIB (SCC244);Fenbuconazole Impurity 1;6-(1-Methyl-1H-pyrazol-4-yl)-1-((6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl)sulfonyl)-1H-pyrazolo[4,3-b]pyridine;1H-Pyrazolo[4,3-b]pyridine, 6-(1-methyl-1H-pyrazol-4-yl)-1-[[6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]sulfonyl]-;SCC 244,proliferation,tumor,cancer,Glumetinib,bioavailable,oral,HCC,SCC-244,inhibit,c-Met/HGFR,ATP-competitive,cell,NSCLC,Inhibitor
- CBNumber
- CB64667942
- Molecular Formula
- C21H17N9O2S
- Formula Weight
- 459.48
- MOL File
- 1642581-63-2.mol
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Glumetinib Property
- Density
- 1.61±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (>25 mg/ml)
- form
- solid
- pka
- 0.09±0.10(Predicted)
- color
- Beige
- Stability:
- Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 28952
- Product name
- Glumetinib
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 28952
- Product name
- Glumetinib
- Packaging
- 25mg
- Price
- $638
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 28952
- Product name
- Glumetinib
- Packaging
- 5mg
- Price
- $155
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 28952
- Product name
- Glumetinib
- Packaging
- 10mg
- Price
- $290
- Updated
- 2024/03/01
AK Scientific
- Product number
- 1891EF
- Product name
- Glumetinib
- Packaging
- 10mg
- Price
- $421
- Updated
- 2021/12/16
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Glumetinib Chemical Properties,Usage,Production
Description
Glumetinib (1642581-63-2) is a highly selective (2400-fold selectivity against a panel of 312 kinases) and potent (IC50 = 0.42 nM) inhibitor of c-Met kinase.? It induced tumor regression in MET-driven CDX (MKN-45, SNU-5, EBC-1) and PDX (4 NSCLC, 5 HCC) tumor models.
References
Ai et al. (2018), Preclinical Evaluation of SCC244 (Glumetinib), a Novel, Potent, and Highly Selective Inhibitor of c-Met in MET-dependent Cancer Models; Cancer Res., 17 751
Glumetinib Preparation Products And Raw materials
Raw materials
Preparation Products
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Glumetinib Suppliers
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- 0411-62910999 13889544652
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- Country
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