Stevioside

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Chemical Properties Stevia Extract Stevia Stevioside features Stevioside Application Application in Food Industry Toxicology Storage Range and usage Production method

Product Name: Stevioside
CAS No.: 57817-89-7
Chemical Name: Stevioside
Synonyms: Steviosides;STEVIA LEAF EXTRACT;GLUCOSYL STEVIOL GLYCOSIDES;Stevia 95% (froM Stevia rebaudiana) anhydrous;steviosin;Stevioside (90%);Stevioside powder;Stevioside - min 80%;Rebaudin;α-G-Sweet
CBNumber: CB6469397
Molecular Formula: C38H60O18
Formula Weight: 804.88
MOL File: 57817-89-7.mol

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Stevioside Property

Melting point:: 198°C
Boiling point:: 963.3±65.0 °C(Predicted)
alpha: D25 -39.3° (c = 5.7 in H2O)
Density: 1.53±0.1 g/cm3(Predicted)
refractive index: -39.3 ° (C=6, H2O)
FEMA: 4728 | GLUCOSYL STEVIOL GLYCOSIDES
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: soluble25mg/mL, clear
form: powder
pka: 12.51±0.70(Predicted)
color: white
Merck: 14,8810
InChI: InChI=1/C38H60O18/c1-16-11-37-9-5-20-35(2,7-4-8-36(20,3)34(50)55-32-29(49)26(46)23(43)18(13-40)52-32)21(37)6-10-38(16,15-37)56-33-30(27(47)24(44)19(14-41)53-33)54-31-28(48)25(45)22(42)17(12-39)51-31/h17-33,39-49H,1,4-15H2,2-3H3/t17-,18-,19-,20+,21+,22-,23-,24-,25+,26+,27+,28-,29-,30-,31+,32+,33+,35-,36-,37-,38+/s3
InChIKey: ZBXJPXVJLBZBLI-IJGGXEOMSA-N
SMILES: C[C@@]12CCC[C@@](C)(C(=O)O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)[C@@]1([H])CC[C@]13CC(=C)[C@](O[C@]4([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O[C@@]4([H])[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O)(CC[C@@]21[H])C3 |&1:1,5,10,11,12,14,16,21,25,29,31,34,37,39,41,43,45,46,48,50,57,r|
LogP: 4.440 (est)
CAS DataBase Reference: 57817-89-7(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: NZ8175000
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89800
Product name: Stevioside
Purity: phyproof? Reference Substance
Packaging: 20mg
Price: $344
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1622408
Product name: Stevioside
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 30mg
Price: $447
Updated: 2024/03/01

Sigma-Aldrich

Product number: 05420590
Product name: Stevioside
Purity: primary pharmaceutical reference standard
Packaging: 25mg
Price: $444
Updated: 2024/03/01

TCI Chemical

Product number: S0594
Product name: Stevioside
Purity: >85.0%(HPLC)
Packaging: 25g
Price: $146
Updated: 2024/03/01

Cayman Chemical

Product number: 11902
Product name: Stevioside (hydrate)
Purity: ≥95%
Packaging: 5mg
Price: $48
Updated: 2024/03/01

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Stevioside Chemical Properties,Usage,Production

Chemical Properties

White to light yellow crystalline powder. Melting point 198 ℃. 1g the materials can be dissolved in 800ml water, slightly soluble in ethanol. This optical rotation [α] 20/D is-39.3 ° (C = 5.7, H2O). It quickly drains wet in the air. High temperature, acidic and alkaline solution is relatively stable.

Stevia Extract

Stevioside ,as the sweet components of stevia, is distributed in Stevia leaf stem roots and other parts , but has the highest content in the leaves, and its content changes with the growth process ,and is highest in the squaring stage , non-toxic and safe , low-calorie, stevia is favored for these characteristics, is known as the world's third source of sugar, biological activity and product development studies on stevia arouse the interest of many scholars at home and abroad.
Stevia is a mixture of eight kinds of ligands which is constituted by the same diterpene glycoside . Free of sugar and calories; white to yellowish color and suitable taste, no smell, is the new source of sugar of promising development . Stevioside is a sweetener which has been found in the world and approved by the Chinese Ministry of Health to use, low calorific value and very close to the natural sucrose taste. It Is the third natural sweetener in addition to sugar cane, sugar beet ,having development value and health respected,and has been hailed as the international community, "the world's third source of sugar." Stevia as a food sweetener, is preservative widely used in food industry,to produce high-intensity, low-calorie, low-salt, anti-caries food.
Above information is edited by Chemicalbook Lu Yue .

Stevia

Stevia, Asteraceae,Stevia genus , Stevia species, perennial herb. Its origin is Amambay Mountains at the junction of South America Paraguay and Brazil, it is a valuable sugar crop.It has been the introduced and cultivated in China. Whole contain sugar, highest sweetness in blade.
Containing stevioside 14%,glycoside in the branches is equivalent to half of it in the blade. Leaves are dried and crushed to be used as sugar, or by alcohol treatment, ether precipitation,from 20 to 26% egg yellow crude extract can be obtained , the sweetness degree is 100 to 150 times of white sugar, refined products are white , the sweetness degree is 250 to 300 times of white sugar , and the heat is only 1/300 of white sugar. Stevioside has six monomeric species, and has been extracted as white powder diterpene glycosides chrysanthemum glycosides (stevioside), 300 times as sweet as sucrose; diterpene glycosides (steviolbioside); rebaudioside A, up to 450 times the sweetness of sucrose;rebaudiosideB; glycyrrhizin a (dulcoside a) and glycyrrhizin B (dulcosideB), etc., can be used as the sweetener supplement.
Stevia likes humidity, and its soil requirements are not strict. In the moist soil enough fertilizer, at a temperature of above 15 ℃ ,it grows well, less oxygen root system, resistance to humidity, not drought, growth is suppressed when it is short of water in early stage . Early growth stage needs less absorption of nutrients,while exuberant stage absorbs the most nutrients, of NPK, absorbing the most potassium, less phosphorus , moderate nitrogen, compost and lime can increase production. The squaring stage is the appropriate harvest period, when the glucoside and single glucosyl stevioside are the most abundant.
Stevia is not only originally wild, but also cross-pollinated plant, after years of introduction and domestication, their offspring widely are separated, the variation range is very large, its mixed strains include large leaves, small leaves, thick leaves, thin leaves, late maturity, early maturity, disease resistance, no disease resistance, drought resistance, no drought resistance and other types , applications on the production is mainly the big-leaf flower later type.
The above information is edited by the chemicalbook of Tian Ye.

Stevioside features

Because stevia has a high sweetness, low calorie,and it is not metabolized in the human body, non-toxic, safe and reliable, long aftertaste, etc., it is actively used in place of sucrose around the world . China's "food additives health standards" (GB2760-86)provides its maximum is used according to "normal production needs." It has been widely used in the food industry.
Stevioside endures high temperature and has good stability, not fermentable sugar,not only harmless, but also helping regulate blood sugar , assisting in treating cardiovascular disease after eating it . Stevia has good stability, not easy to degeneration and deterioration when added to food, and pH is not required for the added food , and it can be saved for a long time. Stevia taken into the human body does not participate in the body's metabolism, but also does not cause accumulation. Stevia is now being applied to many manufacturers of food, beverage, pharmaceutical and other industries , it is a healthy, non-polluting, natural source of sugar.
Stevioside security is evaluated through Joint Expert Committee on Food Additives (JECFA), France AN-SES (State Food and Environmental Hygiene Department of Labor), and Standards Australia New Zealand Food Authority (FSANZ), the US Food and Drug Administration (FDA) and the European food safety Authority (EFSA) ,the use of stevia extract for the general population, including diabetics, children and pregnant women, as well as side effects or unexplained allergic people, are safe. According to the current research, it has not been found stevioside has an adverse impact on human health.

Stevioside

Stevia (stevioside), also known as stevioside, steviosin, stevia extracts, as a potent sweet component of sweet chrysanthemum (stevia rebaudinan bertoni) which is contained after extraction from the leaves through refined. Stevioside as colorless crystals, 200 to 300 times sweetness of sucrose, with a slight scent of menthol and a small amount of astringency, heat stability, not easily broken.
The large number of tests have proved that stevioside has no toxic side effects, non-carcinogenic, safe to use, with a cool and sweet features.
GB2760-1996 of China regulation provides that: stevioside can be used in candy, cakes, drinks, solid drinks, fried snack foods, preserves, preserved fruits, sauces, soft ice cream and pharmaceutical materials, etc,use appropriately according to production needs

Application

The product has a refreshing sweet taste, sweetness is about 200-300 times that of sucrose. Slightly bitter taste at high concentrations, sweet taste in the mouth is not easy to disappear. The product is one of the natural sweeteners closest to sucrose. As low alorie food sweetener, it can low pressure. As a sucrose substitute agent, the maximum amount should not exceed 1/3, in case of after taste. According to GB2760-86 regulations,it can be used for liquid and solid drinks, candy and pastries according to normal production needs. The disadvantage of this product is its high molecular weight and poor permeability. Mice and rats oral toxicity is LD50> 8.2g/kg.

Application in Food Industry

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Product catagory

Instead of sucrose%

application results

drinks

Carbonated drinks

20~100

On the palate balanced catchy, clear and bright, low-calorie, does not cause tooth decay

fruit juice

30~50

Enhance the flavor, no floc, no precipitation, color clear, extend shelf life,low-calorie

Milk drinks

20~50

Good taste ,,low-calorie

Solid drinks

20~100

Clear cool taste,Convenient measurement,does not cause tooth decay

Cold drinks

icecream

60~100

low-calorie,Enhance the flavor,clear and bright, high sweetness

candy

chewing gum

50~100

does not cause tooth decay,Clear cool taste,long sweet time

Bread,cakes

80~100

Soft,good taste ,extend shelf life

preserves, preserved fruits

80~100

extend shelf life,taste good,decrase cost

cans

20~50

Pure,good taste,extend shelf life

sauces

20~30

No browning, does not cause coloration fermentation phenomenon, shorten the curing time, increase the sweetness,does not occur shrinkage, improve the flavor

Roasted food

50~100

does not cause coloration , increase the sweetness, improve the flavor

Water products

30~50

No browning

White wine

10~100

Improve alcohol taste, reduce spicy flavor

wine

Grape wine

Increase transparency, reduce viscosity, refreshing taste

Champagne

10~100

Toxicology

1. LD50 Mouse oral 34.77g/kg (bw).
2. NOEL oral rat 550mg/kg (bw) (Japan).
China, Japan stevioside toxicity tests (including acute, subacute and chronic toxicity test) results show thatit has no teratogenic, mutagenic and carcinogenic, and is excreted unchanged in the feces and urine after ingestion.

Storage

Stevioside endures heat and light, is very stable in a pH range of 3 to 10,and easy to store.

Range and usage

(1) China's "food additives health standards" (GB 2760-1996) provides that: appropriate stevia is used in candy, cakes, drinks according to production needs .
(2) the actual use of reference:
①when stevioside is mixed with fructose and sucrose or isomerized sugar, its sweetness is improved, so is taste. When using steviocide instead of about 30% sucrose ,the results are better. General amount of orange juice 0.75g/L; fruity gel 0.1g/L; ice cream 0.5g/L. Use 20g stevioside instead of 3.2kg sucrose making egg bread, its shape, color, softness are good and taste good; use 14.88kg stevioside instead of 0.75kg sodium saccharin making plum, it has delicious flavor, aftertaste cool.
②Calorific value of stevioside is only 1/300 of cane sugar, and is not involved in metabolism in the body, and thus is suitable for making health food for the diabetes, obesity, cardiovascular disease patients. For candy, it has anti-caries effects.
③Rebaudioside A (the second main component of ordinary stevioside, 400 times the sweetness of sucrose) of high purity emerges in recent years ,its products and α-G-stevioside by enzymatic conversionf, have better taste and better or food, beverage.
This product can be used as a sweetener for glycyrrhizin. And it is often used with sodium citrate to improve the taste quality.

Production method

Asteraceae small shrub sweet daisy (Stevia rebaudiana Bertoni) leaves which are from Paraguay of northeast America ,dry them , extract them using ethanol , the extract is added ether to precipitate the sweet substance , and then recrystallize them from methanol. In terms of dry leaves, yield is about 6%. Our Jiangsu, Fujian, Xinjiang and other places have large-scale cultivation of stevia.

Chemical Properties

White powder

Occurrence

Stevioside is a naturally occurring sweetener (～200 times sweeter than sucrose) extracted from a South American plant, Stevia rebaudiana Bertoni. The dried leaves, the water extract of leaves, and the refined chemical ingredients, eg, and Rebaudioside A (～300 times sweeter than sucrose), can all be used as sweetening agents. These are collectively referred to as stevia. Discovered in Paraguay and Brazil, the plant was identified in the early 1970s as a plant of high economical value and transported to Japan for cultivation, where the commercialization of stevia leaves extract as a natural sweetener became a success. Today Stevia plant is cultivated primarily in China.

History

Because no food additive petition has been presented to the FDA, stevioside and related materials cannot be used in the United States as food ingredients. An import alert against stevia was issued by the FDA in 1991. In 1995, however, the FDA revised this import alert to allow the importation and use of stevia as a dietary supplement, but not as a sweetener or an ingredient for foods. In 2004, JECFA (Joint Expert Committee of Food Additives) issued a preliminary ADI (Allowed Daily Intake) of 2-mg/kg body weight (based on steviol) for stevia extract. This action may impact favorably on worldwide regulatory approval. As consumer’s demand on naturally sweetened products increases, interest in Stevia, and naturally occurring potent sweeteners in general, is expected to grow. A comprehensive review of stevia is available [Kinghorn, 2002].

Uses

Stevioside is a glycoside from the stevia plant. Stevioside is a natural sweetening agent with sweetness about 250 times that of sugar with negligible effect on blood glucose. Stevioside, much like other steviol glycoside is known for its application in treatment of many diseases like diabetes and high blood pressure. It is also used as a food additive.

Uses

Stevioside is a glycoside from the stevia plant. Stevioside is a natural sweetening agent with sweetness about 250 times that of sugar with negligible effect on blood glucose. Stevioside, much like ot her steviol glycoside is known for its application in treatment of many diseases like diabetes and high blood pressure. It is also used as a food additive and in dietary supplements.

Uses

Stevioside is a natural, calorie-free sweetener obtained from the leaves of the plant stevia rebaudiana bertoni. it is a steviol glycoside in which steviol’s carboxyl and hydroxyl hydrogen atom is replaced with glu- cose; it has two linked glucose molecules at the hydroxyl site. it is the major steviol glycoside found in the stevia plant and is 250–300 times sweeter than sugar. it is heat and ph stable. it has been associ- ated with a bitter and licorice taste. see steviol glycoside.

Definition

ChEBI: Stevioside is a diterpene glycoside that is rubusoside in which the hydroxy group at position 2 of the allylic beta-D-glucoside has been converted to the corresponding beta-D-glucoside. It is a natural herbal sweetener that is 250-300 times sweeter than sucrose (though with a bitter aftertaste), extracted from the Stevia rebaudiana plant native to South America. It has a role as a sweetening agent, an antioxidant, an antineoplastic agent, a hypoglycemic agent, an anti-inflammatory agent and a plant metabolite. It is a diterpene glycoside, an ent-kaurane diterpenoid, a beta-D-glucoside, a tetracyclic diterpenoid and a bridged compound. It is functionally related to a steviol and a rubusoside.

benefits

Stevioside may offer therapeutic benefits, as they have anti-hyperglycemic, anti-hypertensive, anti-inflammatory, anti-tumor, anti-diarrheal, diuretic, and immunomodulatory actions.

Side effects

When taken by mouth: Certain chemicals in stevia, including stevioside and rebaudioside A, are likely safe when used as a food sweetener. Side effects might include bloating, nausea, dizziness, and numbness.

Biochem/physiol Actions

Stevioside reportedly has genotoxic effects in cultured mammalian cells.

storage

+4°C

Stevioside Preparation Products And Raw materials

Raw materials

Ethanol Formaldehyde Ferric chloride Iron chloride hexahydrate Hydrochloric acid Sodium hydroxide

Preparation Products

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Stevioside Suppliers

Brazil 1 Canada 5 Chile 1 China 472 Czech Republic 1 Europe 2 France 2 Germany 12 India 20 Indonesia 2 Israel 1 Italy 3 Japan 7 Lebanon 1 Poland 1 Singapore 2 South Africa 1 Spain 3 Switzerland 2 The Netherlands 1 United Kingdom 11 United States 54 USA 1 Global 606

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Tel: 400-1647117 15221909166
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41438
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RiZhao LiDeShi Chemical Co., Ltd.

Tel: 010-51268198
Fax: 010-63833209
Email: leadershipchem@126.com
Country: China
ProdList: 2549
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Mei Lan Industrial (Shanghai) Co., Ltd.

Tel: 021-58958189
Fax: 021-58957967
Email: wouchina@126.com
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ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
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Email: sales@chem-strong.com
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ProdList: 17982
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Shanghai ideal Industrial Co., Ltd.

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Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
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Chengdu HuaXia Chemical Reagent Co. Ltd

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View Lastest Price from Stevioside manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Stevioside 57817-89-7
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-06

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Stevioside 57817-89-7
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99.7%
Supply Ability: 200000kg
Release date: 2024-04-28

Sinoway Industrial co., ltd.

Product: Stevia Leaf Extract 57817-89-7
Price: US $65.00-35.00/KG
Min. Order: 1KG
Purity: 98% up
Supply Ability: 20 tons
Release date: 2023-12-25

57817-89-7, SteviosideRelated Search:

Diethylstilbestrol D-(-)-Salicin Icariin Matrine Aspartame STEVIA Betaine Molasses 2-(ALLYLOXY)TETRAHYDROPYRAN CYCLOPENTADECANE Cyclohexylacetic acid Isophytol 4-CYCLOHEXYLBUTYRIC ACID 4-tert-Butylcyclohexanol TETRAHYDROIONOL ETHYL 10-UNDECENOATE Rebaudioside A 1-VINYLCYCLOHEXANOL 97 Stevia Leaf Extract

beta-d-glucopyranosyl(1r,4as,7s,8ar,10as)-7-(2-o-(beta-d-glucopyranosyl)-alpha-d-glucopyranosyloxy)-1,4a-dimethyl-12-methyleneperhydro-7,8a-ethanophenanthren-1-carboxylate

beta-d-glucopyranosylester

kaur-16-en-18-oicacid,13-((2-o-beta-d-glucopyranosyl-alpha-d-glucopyranosyl)o

steviosin

(4alpha)-beta-d-glucopyranosyl 13-[(2-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy]kaur-16-en-18-oate

13-[(2-O-beta-D-Glucopyranosyl-alpha-D-glucopyranosyl)oxy]kaur-16-en-18-oic acid beta-D-glucopyranosyl ester

Stevia 95% (froM Stevia rebaudiana) anhydrous

Stevioside (90%)

Stevioside, froM Stevia sp.

Stevioside 13-[(2-O-beta-D-Glucopyranosyl-alpha-D-glucopyranosyl)oxy]kaur-16-en-18-oic acid beta-D-glucopyranosyl ester

Stevioside Reb-A

Total stevia glycosides

stevioside，Stevia sugar

Stevia rebaudiana (Bertoni) Hemsl

GLUCOSYL STEVIOL GLYCOSIDES

Stevioside, 80%, from Stevia sp.

Stevioside, 98%, from Stevia sp.

Stevioside Basic information

Sievioside

Chamomile sugar

Stevioside - min 80%

Rebaudin

Stevioside hydrat

Stevioside

STEVIOSIDE WITH HPLC

Stevia Leaf extract 90%,95%,98%

(4α)-13-[(2-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy]kaur-16-en-18-oicacid β-D-glucopyranosyl ester

Stevioside hydrate

Stevia 95% (froM Stevia rebaudiana)

Stevioside (30 mg)

STEVIA LEAF EXTRACT

Stevioside powder

α-G-Sweet

13-[(-O-D-Glucopyranosyl-D-glucopyranosyl)-oxy]Kaur-16-en-18-oic acid -D-glu-copyranoxyl ester

Kaur-16-en-18-oic acid, 13-(2-O-.beta.-D-glucopyranosyl-.beta.-D-glucopyranosyl)oxy-, .beta.-D-glucopyranosyl ester, (4.alpha.)-

STEVIOSIDE(P)

STEVIOSIDE(RG)

Steviosides

Stevioside&gt

Stevioside Standard

Kaur-16-en-18-oic acid, 13-[(2-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-, β-D-glucopyranosyl ester, (4α)-

Stevioside Solution in Methanol，1000μg/mL

Sweetener Stevioside

STEVIOSIDE/CAS: 57817-89-7

Stevioside USP/EP/BP

Stevia Extract Powder Rebaudioside A Ra 98%

Stevioside (Mixture of Isomers)

enzyme modified steviol glycosides

glucosylated steviol glycosides, 70-80%

Stateside

(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl (4R,4aS,6aR,9S,11aR,11bS)-9-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-4,11b-dimethyl-8-methylenetetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylate

Stevioside (AS)

Stevioside (6CI, 7CI)

Stevia PE 95% (RA 60%)

Kaur-16-en-18-oic acid, 13-[(2-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-, β-D-glucopyranosyl ester, (4α)-

Stevia extract stevia sugar stevia glycoside

Stevioside RS

57817-89-7