2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile
Synthesis- Product Name
- 2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile
- CAS No.
- 93413-76-4
- Chemical Name
- 2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile
- Synonyms
- forVenlafaxine;Venlafaxine Cyano;Venlafaxine Impurity 15;Venlafaxine Impurity 28;VENLAFAXINE CYNO IMPURITY;Venlafaxine Cyano Impurity;Intermediate of Venlafaxine;Venlafaxine Nitrile Impurity;1-[Cyano-(4-Methoxyphenyl)Meth;D,L-VENLAFAXINE, HYDROCHLORIDE int
- CBNumber
- CB6476117
- Molecular Formula
- C15H19NO2
- Formula Weight
- 245.32
- MOL File
- 93413-76-4.mol
2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile Property
- Melting point:
- 121-123°C
- Boiling point:
- 410.1±25.0 °C(Predicted)
- Density
- 1.142±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 13.80±0.20(Predicted)
- color
- White to Almost white
- CAS DataBase Reference
- 93413-76-4(CAS DataBase Reference)
Safety
- HS Code
- 2926.90.4850
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- H1303
- Product name
- (1-Hydroxycyclohexyl)(4-methoxyphenyl)acetonitrile
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 1g
- Price
- $116
- Updated
- 2023/06/20
- Product number
- H1303
- Product name
- (1-Hydroxycyclohexyl)(4-methoxyphenyl)acetonitrile
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 5g
- Price
- $349
- Updated
- 2023/06/20
- Product number
- FC20603
- Product name
- 1-[Cyano-(4-methoxyphenyl)methyl]cyclohexanol
- Packaging
- 25mg
- Price
- $254.5
- Updated
- 2021/12/16
- Product number
- FC20603
- Product name
- 1-[Cyano-(4-methoxyphenyl)methyl]cyclohexanol
- Packaging
- 10mg
- Price
- $139.8
- Updated
- 2021/12/16
- Product number
- FC20603
- Product name
- 1-[Cyano-(4-methoxyphenyl)methyl]cyclohexanol
- Packaging
- 50mg
- Price
- $462
- Updated
- 2021/12/16
2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile Chemical Properties,Usage,Production
Synthesis
A mixture of p-methoxyphenylacetonitrile 36 (100 g, 0.68 mol), 10%
aqueous NaOH solution (100 ml, 0.25 mol) and TBAHSO4 (5 g, 0.014
mol) was stirred at room temperature for 30 minutes. A dark red colour
appeared. To this was added cyclohexanone 34 (67 g, 0.680 mol) in
small portions at 0 ºC, with vigorous stirring, in such a way that
temperature should not rise above 10 ºC. A white solid was formed
within 30 minutes to one hour. The solid was crushed and the reaction mixture was further
stirred vigorously at room temperature for one more hour. The solid was filtered, washed
with water till neutral to pH paper and air-dried. Crystallization from ethyl acetatepetroleum ether (500:350, v/v) gave a bright white solid (161.66 g).
Chemical Properties
White Powder
Uses
An intermediate in the synthesis of N,O-Didesmethylvenlafaxine, a metabolite of Venlafaxine
2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(1-HydroxyCyclohexyl)-2-(4-MethoxyPhenyl)Acetonitrile manufacturers
- Product
- 1-[Cyano-(p-methoxyphenyl)methyl]cyclohexanol 93413-76-4
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-04