Triamcinolone diacetate
- Product Name
- Triamcinolone diacetate
- CAS No.
- 67-78-7
- Chemical Name
- Triamcinolone diacetate
- Synonyms
- TAC-D;8357RP;CINO-40;Tedarol;Cenacort;Tracilon;Kenacourt;21-diacetate;Triamolone 40;aristocortsyrup
- CBNumber
- CB6488260
- Molecular Formula
- C25H31FO8
- Formula Weight
- 478.51
- MOL File
- 67-78-7.mol
Triamcinolone diacetate Property
- Melting point:
- 186-188 C
- alpha
- D25 +22° (chloroform)
- Boiling point:
- 608.5±55.0 °C(Predicted)
- Density
- 1.2087 (estimate)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)
- pka
- 11.21±0.70(Predicted)
- form
- Solid
- color
- White
- Water Solubility
- 48mg/L(25 ºC)
- CAS DataBase Reference
- 67-78-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Triamcinolone diacetate(67-78-7)
- EPA Substance Registry System
- Triamcinolone diacetate (67-78-7)
Safety
- WGK Germany
- 3
- HS Code
- 2937220000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 1678005
- Product name
- Triamcinolone diacetate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 350mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- T3676
- Product name
- Triamcinolone Diacetate
- Packaging
- 50MG
- Price
- $74
- Updated
- 2024/03/01
- Product number
- T3676
- Product name
- Triamcinolone Diacetate
- Packaging
- 250MG
- Price
- $219
- Updated
- 2024/03/01
- Product number
- T767170
- Product name
- Triamcinolone16,21-Diacetate
- Packaging
- 250mg
- Price
- $1295
- Updated
- 2021/12/16
- Product number
- T767170
- Product name
- Triamcinolone16,21-Diacetate
- Packaging
- 25mg
- Price
- $160
- Updated
- 2021/12/16
Triamcinolone diacetate Chemical Properties,Usage,Production
Chemical Properties
White Solid
Originator
Aristocort,Lederle,US,1959
Uses
A glucocorticoid that inhibits prolyl hydroxylase activity and used as an antiasthmatic and antiallergic drug.
Uses
antiinflammatory
Uses
A glucocorticoid that inhibits prolyl hydroxylase activity, Triamcinolone diacetate can be used as an antiasthmatic and antiallergic drug.
Definition
ChEBI: Triamcinolone diacetate is a corticosteroid hormone.
Manufacturing Process
To a solution of 16α,21-diacetoxy-11β,17α-dihydroxy-9α-fluoro-4-pregnene- 3,20-dione (1.0 g) in tertiary-butanol (160 ml) and glacial acetic acid (1.6 ml) was added 600 mg of selenium dioxide, the mixture swept with nitrogen and kept at 70°C for 24 hours, selenium dioxide (350 mg) added, and the mixture swept with nitrogen and allowed to stand for another 24 hours. The reaction mixture was filtered, and the filtrate was evaporated to dryness under reduced pressure. The material so obtained was dissolved in ethyl acetate, washed with saturated sodium bicarbonate, water, cold freshly prepared ammonium sulfide solution, cold dilute ammonia water, cold dilute hydrochloric acid, and finally with water. After treatment with anhydrous sodium sulfate and activated charcoal, filtration through diatomaceous earth and evaporation to dryness under reduced pressure, 850 mg of a tan glass was obtained. Paper strip chromatographic analysis showed predominantly product plus a small amount of starting material. The 850 mg was chromatographed on 320 g of diatomaceous earth containing 160 ml of stationary phase of a solvent system composed of 3,4,3,2-ethyl acetate-petroleum ether (boiling point 90°C to 100°C), methanol, and water, respectively. The column dimensions were 3.8 cm x 78 cm with 460 ml hold back volume. The fifth and sixth hold back volumes were combined and evaporated under reduced pressure to 250 mg of product which, after a single crystallization from acetone petroleum ether, gave 173 mg, melting point 150°C to 190°C. Paper strip chromatography showed a single spot having the same polarity as an authentic sample of 16α,21-diacetoxy-11β,17α-dihydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione. A further crystallization from the same solvent pair gave 134 mg, melting point 185°C to 189°C, bubbles to 230°C.
Therapeutic Function
Glucocorticoid
Safety Profile
An experimental teratogen. Whenheated to decomposition it emits toxic fumes of F-.
Triamcinolone diacetate Preparation Products And Raw materials
Raw materials
Preparation Products
Triamcinolone diacetate Suppliers
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View Lastest Price from Triamcinolone diacetate manufacturers
- Product
- Triamcinolone diacetate 67-78-7
- Price
- US $50.00/KG
- Min. Order
- 10g
- Purity
- 99.8%
- Supply Ability
- 10tons
- Release date
- 2019-11-06
- Product
- Triamcinolone diacetate 67-78-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24