(S)-2-Amino-3-methoxypropanoic acid
- Product Name
- (S)-2-Amino-3-methoxypropanoic acid
- CAS No.
- 32620-11-4
- Chemical Name
- (S)-2-Amino-3-methoxypropanoic acid
- Synonyms
- O-METHYL-L-SERINE;H-Ser(Me)-OH;H-L-Ser(Me)-OH;O-METHYL-L-SER;L-O-Methylserine;L-Serine, O-Methyl-;DL-3-Methoxy-alanine;O-Methyl-L-Serine·HCl;(+)-O-Methyl-L-serine;(S)-BETA-METHOXYALANINE
- CBNumber
- CB6490535
- Molecular Formula
- C4H9NO3
- Formula Weight
- 119.12
- MOL File
- 32620-11-4.mol
(S)-2-Amino-3-methoxypropanoic acid Property
- Melting point:
- 210-215 °C
- Boiling point:
- 222.38°C (rough estimate)
- alpha
- 13.5 º (c=1,6N HCl 25 ºC)
- Density
- 1.3126 (rough estimate)
- refractive index
- 1.4183 (estimate)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2.10±0.10(Predicted)
- form
- solid
- color
- White
- Water Solubility
- soluble
Safety
- Safety Statements
- 24/25
- HS Code
- 29225000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
N-Bromosuccinimide Price
- Product number
- A576933
- Product name
- (S)-2-Amino-3-methoxypropanoicAcid
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- OR55011
- Product name
- (S)-2-Amino-3-methoxypropanoicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $138
- Updated
- 2021/12/16
- Product number
- FA140016
- Product name
- (S)-2-Amino-3-methoxypropanoic acid
- Packaging
- 2g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- AS42082-A
- Product name
- O-Methyl-L-serine
- Purity
- 97+% ee
- Packaging
- 1g
- Price
- $142
- Updated
- 2021/12/16
- Product number
- 4157-1-S3
- Product name
- (S)-2-Amino-3-methoxypropanoic acid
- Packaging
- 1g
- Price
- $152
- Updated
- 2021/12/16
(S)-2-Amino-3-methoxypropanoic acid Chemical Properties,Usage,Production
Chemical Properties
almost white to cream crystalline powder
Definition
ChEBI: O-methylserine is a serine derivative that is L-serine with a methyl group replacing the hydrogen on the hydroxy side chain. It has a role as a metabolite. It is a L-serine derivative and a non-proteinogenic L-alpha-amino acid.
Synthesis
98026-05-2
4219-94-7
The general procedure for the synthesis of O-methyl DL-serine from 2-amino-3-methoxypropionamide was as follows: in small-scale experiments, ACL racemase (Locus, E01594) and PepB (Locus, D84499) were added to an aqueous solution containing α-amino-β-methoxypropionamide. The reaction mixture (20 mL) contained 2 mM pyridoxal 5'-phosphate (PLP), 0.1 M potassium phosphate buffer (KPB, pH 9.0) and 0.5 mol/L α-amino-β-methoxypropionamide. Subsequently, ACL racemization enzyme (3.0 mg) and PepB (1.2 mg) were added and incubated for 18 h at 38°C. The reaction progress was monitored by timed sampling. D/L-α-amino-β-methoxyalanamide and O-methyl-L-serine were determined by HPLC equipped with a Crownpak CR(+) column at a flow rate of 0.5 mL/min using 50 mM HClO4 as solvent system, and the absorbance of the eluate was monitored at 210 nm. After the reaction was completed, O-methyl-L-serine was obtained by deproteinization with trichloroacetic acid and separation by Dowex-X8 (H+) column chromatography. The isolated O-methyl-L-serine (7.98 mmol, 950 mg) was recrystallized by water-methanol-isopropanol-ether solvent mixture to obtain white crystals with more than 99.9% enol purity. The product has a melting point of 211-213 °C (decomposition) and a specific rotation of 1/25D (c 1, 6 mol/L HCl).1H NMR (400 MHz, D2O) data: δ 3.24 (s, 3H), 3.78-3.81 (m, 1H), 3.83 (dd, J = 3.5, 9.8 Hz, 1H), 4.01 (dd, J = 6.1, 9.8 Hz, 1H).13C NMR (100 MHz, D2O) data: 177.3 (CO), 76.5 (CH2), 60.2 (CH), 56.7 (OCH3). Elemental analysis (C4H9NO3) calculated values: C, 40.32; H, 7.58; N, 11.75. measured values: C, 40.35; H, 7.54; N, 11.77. ESI-MS (m/z): 120.1230 [M + H]+.
References
[1] Tetrahedron Asymmetry, 2012, vol. 23, # 24, p. 1653 - 1656
(S)-2-Amino-3-methoxypropanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-2-Amino-3-methoxypropanoic acid manufacturers
- Product
- (S)-2-Amino-3-methoxypropanoic acid 32620-11-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09
- Product
- O-Methylserine 32620-11-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2019-07-29