3,4-Dihydroxybenzonitrile
- Product Name
- 3,4-Dihydroxybenzonitrile
- CAS No.
- 17345-61-8
- Chemical Name
- 3,4-Dihydroxybenzonitrile
- Synonyms
- AKOS B004053;4-CYANOCATECHOL;TIMTEC-BB SBB008582;Protocatechunitrile;4-CYANOPYROCATECHOL;3,4-Dihydroxybenzoni;Protocatachuonitrile;PROTOCATECHUONITRILE;Thymol Impurity 14-d8;3,4-DihydroxybenzonitriL
- CBNumber
- CB6496926
- Molecular Formula
- C7H5NO2
- Formula Weight
- 135.12
- MOL File
- 17345-61-8.mol
3,4-Dihydroxybenzonitrile Property
- Melting point:
- 155-159 °C (lit.)
- Boiling point:
- 334.8±32.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- vapor pressure
- 0Pa at 20℃
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 7.67±0.18(Predicted)
- color
- White to Almost white
- Water Solubility
- insoluble
- BRN
- 2082204
- InChI
- InChI=1S/C7H5NO2/c8-4-5-1-2-6(9)7(10)3-5/h1-3,9-10H
- InChIKey
- NUWHYWYSMAPBHK-UHFFFAOYSA-N
- SMILES
- C(#N)C1=CC=C(O)C(O)=C1
- LogP
- 1.3 at 20℃
- CAS DataBase Reference
- 17345-61-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 36/37-36/37/39-26-22
- RIDADR
- UN3439
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29269090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 538396
- Product name
- 3,4-Dihydroxybenzonitrile
- Purity
- 97%
- Packaging
- 25g
- Price
- $139.65
- Updated
- 2025/07/31
- Product number
- D3352
- Product name
- 3,4-Dihydroxybenzonitrile
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $31
- Updated
- 2025/07/31
- Product number
- D3352
- Product name
- 3,4-Dihydroxybenzonitrile
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $125
- Updated
- 2025/07/31
- Product number
- I779340
- Product name
- 3,4-Dihydroxybenzonitrile
- Packaging
- 25g
- Price
- $220
- Updated
- 2021/12/16
- Product number
- OR9851
- Product name
- 3,4-Dihydroxybenzonitrile
- Packaging
- 5g
- Price
- $15
- Updated
- 2021/12/16
3,4-Dihydroxybenzonitrile Chemical Properties,Usage,Production
Chemical Properties
Off-white powder
Uses
3,4-Dihydroxybenzonitrile is mainly used to synthesize drugs containing thiazole, 2-oxazoline, imidazole, triazole and benzopyrimidine structures, such as quinazoline drugs for anticancer. In recent years, in the field of new materials, 3,4-dihydroxybenzonitrile has also been used in the synthesis of photosensitive materials.
General Description
3,4-Dihydroxybenzonitrile can be prepared from 4-hydroxy-3-methoxybenzonitrile. It can also be synthesized by reacting 3,4-dimethoxybenzonitrile, lithium diisopropylamide (LDA) and 1,3-dimethyl-2-imidazolidinone (DMEU).
Synthesis
3-Methoxy-4-hydroxybenzaldehyde (vanillin) was used as the raw material, and 3-methoxy-4-hydroxybenzonitrile was obtained by reaction with hydroxylamine hydrochloride, and then 3,4-Dihydroxybenzonitrile was synthesized by demethylation reaction with alkali metal halide. The product content was 99.8%, and the total yield based on vanillin was 75.2%.
3,4-Dihydroxybenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,4-Dihydroxybenzonitrile manufacturers
- Product
- 3,4-Dihydroxybenzonitrile 17345-61-8
- Price
- US $10.00-8.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-05
- Product
- 3,4-Dihydroxybenzonitrile 17345-61-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-17
- Product
- Apremilast Impurity 60 17345-61-8
- Price
- US $0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 10g
- Release date
- 2024-04-03