2,2-DIMETHYLTETRAHYDROPYRAN-4-ONE

Product Name: 2,2-DIMETHYLTETRAHYDROPYRAN-4-ONE
CAS No.: 1194-16-7
Chemical Name: 2,2-DIMETHYLTETRAHYDROPYRAN-4-ONE
Synonyms: Ec-000.1609;AKOS NCG-0015;2,2-diMethyloxan-4-one;2,2-DiMethyltetrahydro-4-pyrone;2,2-dimethyl-4-tetrahydropyranone;2,2-DiMethyl-4-oxotetrahydropyran;2,2-DIMETHYL-TETRAHYDRO-PYRAN-4-ONE;2,2-dimethyltetrahydro-4H-pyran-4-one;2,2-diMethyldihydro-2H-pyran-4(3H)-one;2,2-Dimethyltetrahydropyran-4-one ,95%
CBNumber: CB6501594
Molecular Formula: C7H12O2
Formula Weight: 128.17
MOL File: 1194-16-7.mol

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2,2-DIMETHYLTETRAHYDROPYRAN-4-ONE Property

Boiling point:: 60-64°C/8mm
Density: 0.964 g/cm3(Temp: 25 °C)
Flash point:: 60-64°C/8mm
storage temp.: 2-8°C
Appearance: Colorless to light yellow Liquid
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C7H12O2/c1-7(2)5-6(8)3-4-9-7/h3-5H2,1-2H3
InChIKey: BWMNOXJVRHGUQM-UHFFFAOYSA-N
SMILES: C1(C)(C)OCCC(=O)C1

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

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N-Bromosuccinimide Price

TRC

Product number: D480893
Product name: 2,2-Dimethyltetrahydropyran-4-one
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 021441
Product name: 2,2-Dimethyltetrahydropyran-4-one
Purity: 95%
Packaging: 250mg
Price: $21
Updated: 2021/12/16

Ark Pharm

Product number: P000124490
Product name: 2,2-Dimethyltetrahydropyran-4-one
Purity: 95%
Packaging: 250mg
Price: $27
Updated: 2021/12/16

Ark Pharm

Product number: P000124490
Product name: 2,2-Dimethyltetrahydropyran-4-one
Purity: 95%
Packaging: 1g
Price: $36
Updated: 2021/12/16

Matrix Scientific

Product number: 021441
Product name: 2,2-Dimethyltetrahydropyran-4-one
Purity: 95%
Packaging: 500mg
Price: $38
Updated: 2021/12/16

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2,2-DIMETHYLTETRAHYDROPYRAN-4-ONE Chemical Properties,Usage,Production

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

Synthesis

690-94-8

1194-16-7

The general procedure for the synthesis of 2,2-dimethyltetrahydropyran-4-one from dimethyl(vinyl)ethynylmethanol was as follows: diethyl vinyl ethynylmethanol (230 g) was slowly added to a solution containing LA g aqueous solution and SULTUNC acid (5%, 0.6 mL), the reaction was maintained under vigorous stirring for 1 h, and the temperature was slowly elevated to 85 °C. The reaction was carried out in the following manner. Sulfate (18 g) was added in batches over 4 hours at 85 °C. Upon completion of the reaction, the upper liquid layer was separated and the lower layer was neutralized with potassium carbonate and subsequently extracted twice with ether. The separated upper liquid was combined with the ether extract, washed sequentially with potassium carbonate solution and water, and dried with magnesium sulfate. After evaporation to remove the ether, the residue was subjected to vacuum distillation and the 168-175 °C fraction was collected to give the target product 2,2-dimethyltetrahydropyran-4-one (140 g, 53% yield). Anhydrous toluene (150 mL) and sodium (11 g) were heated to reflux, stirred and cooled to room temperature. To this system was slowly added a solution (5-6 mL) of ethyl chloroacetate (63 g, 0.5 mol) and 2,2-dimethyltetrahydropyran-4-one (64 g, 0.5 mol) prepared above. The remaining solution was added dropwise at 23°C over 3-4 hours. When the sodium was completely consumed, anhydrous methanol (8 mL) was added. The reaction mixture was quenched by careful pouring into ice water (100 mL), ether was added and the upper organic phase was separated. The aqueous layer was extracted with ether, all ether extracts were combined, washed with water and dried with magnesium sulfate. After evaporation of the solvent, the residue was subjected to vacuum distillation (101 °C, 2 mmHg) to give the intermediate product (74 g, 70% yield). Ethyl 5,5-dimethyl-1,6-dioxapropane-2,5-octane-2-carbonate (214 g, 1 mol) was added to an aqueous solution (30 mL) of sodium hydroxide (40 g, 1 mol) and stirred at 30 °C for 30 min. After continued stirring for 2 hours, water (200 mL) was added to dissolve the precipitate. The resulting aqueous solution of sodium 5,5-dimethyl-1,6-dioxane-2,5-octane-2-carbonate was heated to 90 °C and 15-20% hydrochloric acid (1 mol) was added dropwise at this temperature over 4 hours. The aldehyde generated during the process was distilled, the reaction solution was saturated with NaCl and extracted with ether (3 x 200 mL). The organic extracts were combined, dried with anhydrous magnesium sulfate and concentrated under vacuum. The residue was distilled under vacuum (61 °C, 7 mmHg) to give the aldehyde intermediate (80 g, 55% yield). To the cooled 2,2-dimethyl-4-formyltetrahydropyran (17 g, 0.5 mol) was added a solution of potassium permanganate (79 g, 0.5 mol) in water (1 L), keeping the reaction temperature at 25°C. After 6 hours of reaction, the MnO2 was removed by filtration and washed with water. The filtrates were combined and evaporated to a volume of 175 mL, acidified with HCl and extracted with ether. The organic phase was dried with anhydrous magnesium sulfate and concentrated under vacuum. The residue was distilled under vacuum (123 °C, 5 mmHg) to give the target carboxylic acid (71 g, 90% yield). The product of Example 82 was prepared by combining tert-butyl 3-tert-butyl-1-OXA-8-azaspiro[4.5]decane-8-carboxylate with the carboxylic acid according to the method of Examples 78 and 71 in U.S. Patent 6,489,354 and the steps of Example 11. Mass spectrometry analysis showed m/e = 585 (M + 1).

References

[1] Patent: WO2004/58763, 2004, A1. Location in patent: Page 58-59
[2] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1940, p. 223
[3] Chem.Abstr., 1942, p. 748
[4] Chem. Zentralbl., 1942, vol. 113, # I, p. 740
[5] Zhurnal Obshchei Khimii, 1948, vol. 18, p. 1336

2,2-DIMETHYLTETRAHYDROPYRAN-4-ONE Preparation Products And Raw materials

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Preparation Products

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2,2-DIMETHYLTETRAHYDROPYRAN-4-ONE Suppliers

China 166 Finland 1 Germany 3 India 2 United Kingdom 3 United States 17 Global 192

Accela ChemBio Inc.

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View Lastest Price from 2,2-DIMETHYLTETRAHYDROPYRAN-4-ONE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2,2-Dimethyltetrahydropyran-4-one 1194-16-7
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

Shaanxi Dideu New Materials Co. Ltd

Product: 2,2-DIMETHYLTETRAHYDROPYRAN-4-ONE 1194-16-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-10

Wuhan Boyuan Import & Export Co., LTD

Product: 2,2-DIMETHYLTETRAHYDROPYRAN-4-ONE 1194-16-7
Price: US $25.00/g
Min. Order: 1g
Purity: 99.96%
Supply Ability: 500ton
Release date: 2023-06-13

1194-16-7, 2,2-DIMETHYLTETRAHYDROPYRAN-4-ONERelated Search:

2H-PYRAN-3(4H)-ONE, DIHYDRO- 2,2-dimethyltetrahydro-2H-pyran-4-carbonitrile(SALTDATA: FREE) 2H-Pyran-4-carboxylicacid,tetrahydro-,hydrazide(9CI) TETRAHYDRO-2H-PYRAN-2-ETHANOL 4-methyloxan-4-amine Tetrahydro-2-furancarboxaldehyde Tetrahydro-3-thiophenesulfonyl chloride 1,1-dioxide 2-Methyl-5-hydroxypentanoic acid lactone 2-HYDROXYTETRAHYDROPYRAN TETRAHYDROTHIOPYRAN-4-OL 97 1-Pyrrolidinesulfonamide(7CI,8CI,9CI) TETRAHYDROTHIOPHENE-3-CARBOXYLIC ACID 1,1-DIOXIDE 2-phenyldihydro-2H-pyran-4(3H)-one 3-METHYL-TETRAHYDROFURAN-3-CARBOXYLIC ACID 2H-PYRAN-3-AMINE, TETRAHYDRO- TETRAHYDRO-2H-PYRAN-3-CARBOXYLIC ACID Forskolin 4H-PYRAN-4-ONE

AKOS NCG-0015

Tetrahydro-2,2-dimethyl-4H-pyran-4-one, 95%

2,2-dimethyltetrahydro-4H-pyran-4-one

Ec-000.1609

2,2-Dimethyltetrahydropyran-4-one ,95%

2,2-diMethyldihydro-2H-pyran-4(3H)-one

2,2-DiMethyltetrahydro-4-pyrone

4H-Pyran-4-one, tetrahydro-2,2-diMethyl-

2,2-diMethyloxan-4-one

2,2-DiMethyl-4-oxotetrahydropyran

2,2-dimethyl-4-tetrahydropyranone

2,2-DIMETHYL-TETRAHYDRO-PYRAN-4-ONE

2,2-DIMETHYLTETRAHYDROPYRAN-4-ONE ISO 9001：2015 REACH

1194-16-7