1-BOC-ISONIPECOTIC ACID HYDRAZIDE
Uses- Product Name
- 1-BOC-ISONIPECOTIC ACID HYDRAZIDE
- CAS No.
- 187834-88-4
- Chemical Name
- 1-BOC-ISONIPECOTIC ACID HYDRAZIDE
- Synonyms
- KA-0848;-4-(hydrazinocarbonyL;1-BOC-ISONIPECOTIC ACID HYDRAZIDE;1-boc-isonipecotis acid hydrazide;1-Boc-piperidine-4-carbohydrazide;)tetrahydro-1(2H)-pyridinecarboxyL;N-Boc-piperidine-4-carboxylhydrazide;1-Boc-piperidine-4-carboxylhydrazide;1-Boc-4-(hydrazinocarbonyl)piperidine;1-Boc-isonipecotic acid hydrazide, 95%
- CBNumber
- CB6663186
- Molecular Formula
- C11H21N3O3
- Formula Weight
- 243.3
- MOL File
- 187834-88-4.mol
1-BOC-ISONIPECOTIC ACID HYDRAZIDE Property
- Melting point:
- 104-106°C
- Boiling point:
- 409.2±34.0 °C(Predicted)
- Density
- 1.147±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- form
- crystalline solid
- pka
- 13.01±0.20(Predicted)
- color
- White
- InChI
- InChI=1S/C11H21N3O3/c1-11(2,3)17-10(16)14-6-4-8(5-7-14)9(15)13-12/h8H,4-7,12H2,1-3H3,(H,13,15)
- InChIKey
- JLIKTOWFNQDEME-UHFFFAOYSA-N
- SMILES
- C1C(C(NN)=O)CCN(C(=O)OC(C)(C)C)C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B656723
- Product name
- 1-Boc-IsonipecoticAcidHydrazide
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- B038
- Product name
- 1-Boc-Isonipecoticacidhydrazide
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- OR14039
- Product name
- 1-(tert-Butoxycarbonyl)piperidine-4-carbohydrazide
- Packaging
- 1g
- Price
- $41
- Updated
- 2021/12/16
- Product number
- 4H56-1-D1
- Product name
- 1-(tert-Butoxycarbonyl)piperidine-4-carbohydrazide
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB126948
- Product name
- tert-Butyl 4-(hydrazinocarbonyl)piperidine-1-carboxylate
- Packaging
- 250mg
- Price
- $57.5
- Updated
- 2021/12/16
1-BOC-ISONIPECOTIC ACID HYDRAZIDE Chemical Properties,Usage,Production
Uses
Ethyl N-Boc-4-piperidinecarboxylate is a key intermediate in the synthesis of sodium channel blockers used to treat stroke patients. It is also a key intermediate in the preparation of tumor necrosis factor converting enzyme inhibitors. Furthermore, it is a key intermediate in the synthesis of 1-BOC-4-piperidinecarboxylhydrazide.
Synthesis
142851-03-4
187834-88-4
The general procedure for the synthesis of 1-BOC-4-piperidinecarbohydrazide from ethyl N-Boc-4-piperidinecarboxylate is as follows: Example 4: Synthesis of tert-butyl 4-(hydrazinocarbonyl)piperidine-1-carboxylate 1. 10.0 g (38.9 mmol) of 4-tert-butyl 4-ethylpiperidine-1,4-dicarboxylate was dissolved in 35 mL of ethanol and 3.8 mL (3.90 g, 78 mmol) of hydrazine hydrate was added slowly under stirring conditions. 2. The reaction mixture was heated to reflux with continuous stirring for 9 hours. 3. Upon completion of the reaction, the mixture was cooled to room temperature, 1.9 mL (39 mmol) of hydrazine hydrate was added, and stirring was continued at reflux for 24 hours. 4. At the end of the reaction, the solvent was removed by concentration under reduced pressure and concentrated again by adding 50 mL of ethanol. 5. 150 mL of ether was added to the concentrate and the mixture was sonicated in an ultrasonic bath for 5 minutes. 6. The solid product was collected by filtration and dried to give 9.20 g of white solid in 97% yield. Product Characterization. LCMS (Method 6): Rt = 0.95 min, m/z = 244 (M+H)+ 1H-NMR (400 MHz, DMSO-d6): δ = 8.99 (s, 1H), 4.17 (br, 2H), 3.95 (br d, 2H), 2.71 (br, 2H), 2.23 (m, 1H), 1.60 (m, 2H), 1.40 (m, 11H).
References
[1] MedChemComm, 2018, vol. 9, # 12, p. 2083 - 2090
[2] Patent: US2011/144131, 2011, A1. Location in patent: Page/Page column 29
[3] Patent: WO2008/11130, 2008, A2. Location in patent: Page/Page column 151
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 15, p. 4430 - 4448
[5] Patent: WO2018/37223, 2018, A1. Location in patent: Page/Page column 147; 148
1-BOC-ISONIPECOTIC ACID HYDRAZIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-BOC-ISONIPECOTIC ACID HYDRAZIDE manufacturers
- Product
- 1-BOC-ISONIPECOTIC ACID HYDRAZIDE 187834-88-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2018-08-08