Methoxycarbonyl-L-tert-leucine
Description References- Product Name
- Methoxycarbonyl-L-tert-leucine
- CAS No.
- 162537-11-3
- Chemical Name
- Methoxycarbonyl-L-tert-leucine
- Synonyms
- (S)-2-acetamido-3,3-dimethylbutanoic acid;MOC-L-tert.Leucine;N-Methoxycarbonyl-tert-leucine;(S)-2-(MethoxycarbonylaMino)-3,3-diMethylbutanoic acid;Moc-L-tle;Moc-Tle-OH;MOC-L-Norleucine;Moc-L-tert-lecine;MOC-L-tert. Leucin;Atazanavir USP RC A
- CBNumber
- CB6663762
- Molecular Formula
- C8H15NO4
- Formula Weight
- 189.21
- MOL File
- 162537-11-3.mol
Methoxycarbonyl-L-tert-leucine Property
- Melting point:
- 1090C
- Boiling point:
- 320.9±25.0 °C(Predicted)
- Density
- 1.126±0.06 g/cm3(Predicted)
- vapor pressure
- 0Pa at 25℃
- storage temp.
- 2-8°C
- solubility
- Soluble in ethyl acetate and methanol.
- pka
- 4.46±0.10(Predicted)
- form
- powder
- color
- White to off-white
- Water Solubility
- 26.4g/L at 20℃
- InChI
- InChI=1S/C8H15NO4/c1-8(2,3)5(6(10)11)9-7(12)13-4/h5H,1-4H3,(H,9,12)(H,10,11)/t5-/m1/s1
- InChIKey
- NWPRXAIYBULIEI-RXMQYKEDSA-N
- SMILES
- C(O)(=O)[C@H](C(C)(C)C)NC(OC)=O
- LogP
- 0.832 at 21℃
Safety
- HS Code
- 2933399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- PHR3001
- Product name
- Atazanavir Related Compound A
- Purity
- pharmaceutical secondary standard, certified reference material
- Packaging
- 50MG
- Price
- $461
- Updated
- 2024/03/01
- Product number
- 1044356
- Product name
- Atazanavir Related Compound A
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 25mg
- Price
- $1210
- Updated
- 2024/03/01
- Product number
- H35148
- Product name
- N-Methoxycarbonyl-L-tert-leucine, 98%
- Packaging
- 5g
- Price
- $147
- Updated
- 2021/12/16
- Product number
- H35148
- Product name
- N-Methoxycarbonyl-L-tert-leucine, 98%
- Packaging
- 1g
- Price
- $37.3
- Updated
- 2021/12/16
- Product number
- H35148
- Product name
- N-Methoxycarbonyl-L-tert-leucine, 98%
- Packaging
- 25g
- Price
- $593
- Updated
- 2021/12/16
Methoxycarbonyl-L-tert-leucine Chemical Properties,Usage,Production
Description
Methoxycarbonyl-L-tert-leucine is a kind of amino acid deriviative. It is a very useful intermediate for efficient synthesis of the HIV protease inhibitor BMS-232632 as well as atazanavir bisulfate.
References
Zhongmin Xu, †, et al. "Process Research and Development for an Efficient Synthesis of the HIV Protease Inhibitor BMS-232632." Organic Process Research & Development 6.3(2002):323-328.
Simhadri, Srinivas. "Process for the preparation of atazanavir bisulfate." (2016).
https://www.alfa.com/en/search/?q=14328-63-3
Chemical Properties
White Solid
Uses
The coupling of the two key intermediates, N-(methoxycarbonyl)-l-tert-leucine acylated benzyl hydrazine and chloromethyl ketone, via an S N 2 reaction furnished the amino ketone in high yield under our optimized conditions in practical synthesis of the HIV Protease Inhibitor Atazanavir via a Highly diastereoselective Reduction Approach.
Flammability and Explosibility
Not classified
Methoxycarbonyl-L-tert-leucine Preparation Products And Raw materials
Raw materials
Preparation Products
Methoxycarbonyl-L-tert-leucine Suppliers
- Tel
- --
- Fax
- --
- ian.freelance@dsm.com
- Country
- The Netherlands
- ProdList
- 78
- Advantage
- 30
View Lastest Price from Methoxycarbonyl-L-tert-leucine manufacturers
- Product
- Methoxycarbonyl-L-tert-leucine 162537-11-3
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 1000kg
- Release date
- 2021-08-28
- Product
- N-Methoxycarbonyl-L-tert-Leucine 162537-11-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2022-02-21
- Product
- Methoxycarbonyl-L-tert-leucine 162537-11-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- 99
- Supply Ability
- 20tons
- Release date
- 2024-02-06