Cbz-L-tert-Leucine

Product Name: Cbz-L-tert-Leucine
CAS No.: 62965-10-0
Chemical Name: Cbz-L-tert-Leucine
Synonyms: Z-TLE-OH;Cbz-L-Tle-OH;Z-(TBU)GLY-OH;Z-L-TERT-LEUCINE;CBZ-L-TERT-LEUCINE;Z-L-T-BUTYLGLYCINE;CBZL-L-TERT-LEUCINE;N-Cbz-L-tert-Leucine;Cbz-L-tert-Leucine,97%;3-Methyl-N-CBZ-L-valine
CBNumber: CB1345021
Molecular Formula: C14H19NO4
Formula Weight: 265.3
MOL File: 62965-10-0.mol

More

Less

Cbz-L-tert-Leucine Property

Boiling point:: 436.4±38.0 °C(Predicted)
Density: 1.160±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: Chloroform (Sparingly), Methanol (Slightly)
form: Oil
pka: 4.01±0.10(Predicted)
color: Pale to Light Yellow
optical activity: Consistent with structure
CAS DataBase Reference: 62965-10-0

More

Less

Safety

HazardClass: IRRITANT
HS Code: 29225090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Usbiological

Product number: 242840
Product name: Z-L-tert-leucine
Packaging: 1g
Price: $259
Updated: 2021/12/16

TRC

Product number: C227750
Product name: Cbz-L-tert-Leucine
Packaging: 25g
Price: $590
Updated: 2021/12/16

TRC

Product number: C227750
Product name: Cbz-L-tert-Leucine
Packaging: 2g
Price: $80
Updated: 2021/12/16

Matrix Scientific

Product number: 054333
Product name: (2S)-2-{[(Benzyloxy)carbonyl]amino}-3,3-dimethylbutanoic acid
Purity: >90%
Packaging: 1g
Price: $58
Updated: 2021/12/16

Activate Scientific

Product number: AS34340
Product name: Cbz-L-tert-Leucine
Purity: 95+%
Packaging: 1g
Price: $17
Updated: 2021/12/16

More

Less

Cbz-L-tert-Leucine Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Thick Oil

Uses

Cbz-L-tert-Leucine is a leucine derivative used in the preparation of various pharmaceutical agents such as TRPV4 antagonists, HIV-1 protease inhibitors and serine protease inhibitors.

Synthesis

13139-17-8

20859-02-3

62965-10-0

Step A: Synthesis of (S)-2-(((benzyloxy)carbonyl)amino)-3,3-dimethylbutanoic acid; to a methanolic (200 mL) suspension of L-tert-leucine (11.88 g, 90.7 mmol) was sequentially added triethylamine (26.56 mL, 190 mmol) and N-(benzyloxycarbonyloxy)succinimide (24.88 g, 99.8 mmol). The reaction mixture was stirred at room temperature for 14 hours. After completion of the reaction, methanol was removed by rotary evaporator under reduced pressure to give a viscous light yellow oil. The oily substance was dissolved in ethyl acetate (100 mL) and the organic layer was washed sequentially with 1 M hydrochloric acid (15 mL) and saturated saline. The organic layer was dried over anhydrous magnesium sulfate and filtered, and the filtrate was concentrated under reduced pressure by rotary evaporator to afford the title compound (S)-2-(((benzyloxy)carbonyl)amino)-3,3-dimethylbutanoic acid as an oil (24 g, quantitative yield).1H-NMR (CDCl3) δ: 7.43-7.36 (5H, m), 5.36 (1H, d, J = 9.4 Hz) , 5.12 (2H, br s), 4.20 (1H, d, J = 9.6 Hz), 1.02 (9H, s).LRMS: m/z 266 [M + H]+, 264 [M - H]-, 529 [2M - H]-.

References

[1] Patent: EP1210330, 2005, B1. Location in patent: Page/Page column 9-10

Cbz-L-tert-Leucine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Cbz-L-tert-Leucine Suppliers

Canada 3 China 125 Germany 6 India 4 Japan 4 United Kingdom 2 United States 17 Global 161

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

More

Less

View Lastest Price from Cbz-L-tert-Leucine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Cbz-L-Tle-OH 62965-10-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2023-12-18

Career Henan Chemical Co

Product: Cbz-L-tert-Leucine 62965-10-0
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2018-07-31

62965-10-0, Cbz-L-tert-LeucineRelated Search:

tert-Butanol N-Carbobenzyloxyglycine 6-Aminocaproic acid N-CARBOBENZOXY-DL-LEUCINE ETHANE Dimethyl carbonate Dimethyl ether Dimethyl sulfide Dimethyl sulfate Glycine L-tert-Leucine Dimethyl fumarate N,N-Dimethylformamide Dimethyl sulfoxide CBZ-L-TERT-LEUCINE DICYCLOHEXYLAMMONIUM SALT DL-tert-Leucine (R)-TERT-LEUCINOL Methoxycarbonyl-L-tert-leucine

3,3-dimethyl-2-(phenylmethoxycarbonylamino)butanoic acid

2S-BenzyloxycarbonylaMino-3,3-diMethylbutyric Acid

3-Methyl-N-[(phenylMethoxy)carbonyl]-L-valine

Benzyloxycarbonyl-L-tert-leucine

N-(Benzyloxycarbonyl)-L-tert-butylglycine

N-Benzyloxycarbonyl-tert-leucine

N-Carbobenzoxy-(S)-tert-leucine

(S)-2-(((Benzyloxy)carbonyl)aMino)-3,3-diMethylbutanoic acid

(2S)-2-([(Benzyloxy)Carbonyl]AMino)-3,3-DiMethylbutanoic Acid DicyclohexylaMine Salt

N-Cbz-L-tert-Leucine

Cbz-L-Tle-OH

L-Valine, 3-Methyl-N-[(phenylMethoxy)carbonyl]-

CBZ-L-tert Leucine i-propyl aMine

CBZ-L-TERT-LEUCINE

CBZL-L-TERT-LEUCINE

N-ALPHA-CARBOBENZOXY-L-ALPHA-T-BUTYLGLYCINE

N-ALPHA-CARBOBENZOXY-L-TERT-LEUCINE

Z-TLE-OH

Z-(TBU)GLY-OH

Z-L-T-BUTYLGLYCINE

Z-L-TERT-LEUCINE

(S)-2-(benzyloxycarbonyl)-3,3-dimethylbutanoic aci

(S)-N-Cbz-2-amino-3,3-dimethyl-butyric acid

CBZ-L-2-AMINO-3,3-DIMETHYLBUTANOIC ACID

N-Benzyloxycarbonyl-L-tert-leucine

(2S)-2-{[(Benzyloxy)carbonyl]amino}-3,3-dimethylbutanoic acid

Z-Tle-OH Cbz-L-tert-Leucine

Cbz-L-tert-Leucine USP/EP/BP

N-α-Carbobenzoxy-L-tert-leucine

Cbz-L-tert-Leucine,62965-10-0

(2S)-3,3-dimethyl-2-(phenylmethoxycarbonylamino)butanoic acid

Cbz-L-tert-Leucine,97%

3-Methyl-N-CBZ-L-valine

62965-10-0

63965-10-0

629665-10-0

Intermediates & Fine Chemicals

Pharmaceuticals

Amino Acids & Deriv.

Amino Acid Derivatives

Leucine [Leu, L]

Aromatics

Amino Acids & Derivatives

CHIRAL CHEMICALS