Methoxycarbonyl-L-tert-leucine

Description References

Product Name: Methoxycarbonyl-L-tert-leucine
CAS No.: 162537-11-3
Chemical Name: Methoxycarbonyl-L-tert-leucine
Synonyms: (S)-2-acetamido-3,3-dimethylbutanoic acid;MOC-L-tert.Leucine;N-Methoxycarbonyl-tert-leucine;(S)-2-(MethoxycarbonylaMino)-3,3-diMethylbutanoic acid;Moc-L-tle;Moc-Tle-OH;MOC-L-Norleucine;Moc-L-tert-lecine;MOC-L-tert. Leucin;Atazanavir USP RC A
CBNumber: CB6663762
Molecular Formula: C8H15NO4
Formula Weight: 189.21
MOL File: 162537-11-3.mol

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Methoxycarbonyl-L-tert-leucine Property

Melting point:: 1090C
Boiling point:: 320.9±25.0 °C(Predicted)
Density: 1.126±0.06 g/cm3(Predicted)
vapor pressure: 0Pa at 25℃
storage temp.: 2-8°C
solubility: Soluble in ethyl acetate and methanol.
pka: 4.46±0.10(Predicted)
form: powder
color: White to off-white
Water Solubility: 26.4g/L at 20℃
InChI: InChI=1S/C8H15NO4/c1-8(2,3)5(6(10)11)9-7(12)13-4/h5H,1-4H3,(H,9,12)(H,10,11)/t5-/m1/s1
InChIKey: NWPRXAIYBULIEI-RXMQYKEDSA-N
SMILES: C(O)(=O)[C@H](C(C)(C)C)NC(OC)=O
LogP: 0.832 at 21℃

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Safety

HS Code: 2933399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR3001
Product name: Atazanavir Related Compound A
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 50MG
Price: $461
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1044356
Product name: Atazanavir Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25mg
Price: $1210
Updated: 2024/03/01

Alfa Aesar

Product number: H35148
Product name: N-Methoxycarbonyl-L-tert-leucine, 98%
Packaging: 5g
Price: $147
Updated: 2021/12/16

Alfa Aesar

Product number: H35148
Product name: N-Methoxycarbonyl-L-tert-leucine, 98%
Packaging: 1g
Price: $37.3
Updated: 2021/12/16

Alfa Aesar

Product number: H35148
Product name: N-Methoxycarbonyl-L-tert-leucine, 98%
Packaging: 25g
Price: $593
Updated: 2021/12/16

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Methoxycarbonyl-L-tert-leucine Chemical Properties,Usage,Production

Description

Methoxycarbonyl-L-tert-leucine is a kind of amino acid deriviative. It is a very useful intermediate for efficient synthesis of the HIV protease inhibitor BMS-232632 as well as atazanavir bisulfate.

References

Zhongmin Xu, †, et al. "Process Research and Development for an Efficient Synthesis of the HIV Protease Inhibitor BMS-232632." Organic Process Research & Development 6.3(2002):323-328.
Simhadri, Srinivas. "Process for the preparation of atazanavir bisulfate." (2016).
https://www.alfa.com/en/search/?q=14328-63-3

Chemical Properties

White Solid

Uses

The coupling of the two key intermediates, N-(methoxycarbonyl)-l-tert-leucine acylated benzyl hydrazine and chloromethyl ketone, via an S N 2 reaction furnished the amino ketone in high yield under our optimized conditions in practical synthesis of the HIV Protease Inhibitor Atazanavir via a Highly diastereoselective Reduction Approach.

Flammability and Explosibility

Not classified

Methoxycarbonyl-L-tert-leucine Preparation Products And Raw materials

Raw materials

Preparation Products

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Methoxycarbonyl-L-tert-leucine Suppliers

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View Lastest Price from Methoxycarbonyl-L-tert-leucine manufacturers

Chongqing Zhihe Biopharmaceutical Co., Ltd.

Product: Methoxycarbonyl-L-tert-leucine 162537-11-3
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: 99
Supply Ability: 20tons
Release date: 2024-02-06

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Methoxycarbonyl-L-tert-leucine 162537-11-3
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min
Supply Ability: 1000kg
Release date: 2021-08-28

Shanghai Joiny Pharmaceutical Co.,LTD

Product: N-Methoxycarbonyl-L-tert-Leucine 162537-11-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2022-02-21

162537-11-3, Methoxycarbonyl-L-tert-leucineRelated Search:

DL-Leucine Stearic acid tert-Butyl peroxyacetate N-CARBOBENZOXY-DL-LEUCINE tert-Butanol L-tert-Leucine Folic acid Citric acid METHOXYCARBONYLSULFENYL CHLORIDE Ethyl 2-(Chlorosulfonyl)acetate Ascoric Acid Fmoc-L-tert-leucine (S)-N-Boc-3,3-dimethylpyrrolidine-2-carboxylic acid (2S,4R)-N-Boc-4-hydroxy-3,3-dimethylpyrrolidine-2-carboxylic acid Z-TLE-OH DCHA N-(METHOXYCARBONYL)-L-TERT-LEUCINE Cbz-L-tert-Leucine FMOC-D-ALPHA-T-BUTYLGLYCINE

MOC-L-tert.Leucine

(S)-2-Methoxycarbonylamino-3,3-dimethylbutyric acid

Methoxycarbonyl-L-tert-leucine

N-(Methoxycarbonyl)-3-methyl-L-valine

N-Methoxycarbonyl-tert-leucine

Atazanavir related coMpound A

MOC-L-tert. Leucin

L-Valine,N-(Methoxycarbonyl)-3-Methyl-

(S)-2-(MethoxycarbonylaMino)-3,3-diMethylbutanoic acid

Moc-L-tert-lecine

(S)-2-(Methoxycarbonyl)-3,3-diMethylbutanoic acid

Methyl Carbonyl L-tert Leucine

(2S)-2-ACETAMIDO-3,3-DIMETHYLBUTANOIC ACID

N-Moc-L-tert-Leucine

(S)-2-acetamido-3,3-dimethylbutanoic acid

Atazanavir USP Related Compound A

(S)-N-(METHOXYCARBONYL)-TERT-LEUCINE

Methylcarbonyl-L-t-Leucine

Methoxycarbonyl-L-tert-leucinef

Atazanavir side chain

Atazanavir Impurity 15

Atazanavir USP RC A

N-Methoxycarbonyl-L-tert-leucine,98%

Methoxycarbonyl-L-tert-leucine USP/EP/BP

Moc-Tle-OH

Atazanavir Related Compund A (Methoxycarbonyl-L-tert-leucine)

Atazanavir Related Compound A ((S)-2-[(Methoxycarbonyl)amino]-3,3-dimethylbutanoic acid) (1044356)

MOC-L-Norleucine

Atazanavir Sulfate EP Impurity K

Moc-L-tle

N-(Methoxycarbonyl)-tert-L-leucine

Azanavir EP Impurity K

Atazanavir Sulfate Impurity K

162537-11-3

C38H54N6O11S

Amino Acid Derivatives

Amino Acids 13C, 2H, 15N

Amino Acids & Derivatives

Chiral Reagents