ChemicalBook > CAS DataBase List > 2-Amino-3-nitro-4-picoline

2-Amino-3-nitro-4-picoline

Product Name: 2-Amino-3-nitro-4-picoline
CAS No.: 6635-86-5
Chemical Name: 2-Amino-3-nitro-4-picoline
Synonyms: NSC 52453;TIMTEC-BB SBB006636;4-METHYL-3-NITRO-PYRI;2-AMINO-3-NITRO-4-PICOLINE;2-AMino-4-Methyl-3-nitrop...;2-Amino-3-nitro-4-picoline,98%;4-Methyl-3-nitro-2-pyridinamine;2-amin-3-nitro-4-methylpyridine;3-Nitro-4-methyl-2-pyridinamine;4-methyl-3-nitropyridin-2-amine
CBNumber: CB6671998
Molecular Formula: C6H7N3O2
Formula Weight: 153.14
MOL File: 6635-86-5.mol

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2-Amino-3-nitro-4-picoline Property

Melting point:: 136-140 °C(lit.)
Boiling point:: 276.04°C (rough estimate)
Density: 1.3682 (rough estimate)
refractive index: 1.6500 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: Crystalline Powder
pka: 2.97±0.47(Predicted)
color: Yellow
BRN: 139111
InChI: InChI=1S/C6H7N3O2/c1-4-2-3-8-6(7)5(4)9(10)11/h2-3H,1H3,(H2,7,8)
InChIKey: IKMZGACFMXZAAT-UHFFFAOYSA-N
SMILES: C1(N)=NC=CC(C)=C1[N+]([O-])=O
CAS DataBase Reference: 6635-86-5(CAS DataBase Reference)
NIST Chemistry Reference: Pyridine, 2-amino-3-nitro-4-methyl-(6635-86-5)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-36-36/37/39-22
WGK Germany: 3
F: 10
HazardClass: IRRITANT
HS Code: 29333999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 290084
Product name: 2-Amino-4-methyl-3-nitropyridine
Purity: 98%
Packaging: 25g
Price: $300
Updated: 2023/06/20

Sigma-Aldrich

Product number: 290084
Product name: 2-Amino-4-methyl-3-nitropyridine
Purity: 98%
Packaging: 5g
Price: $152
Updated: 2023/01/07

TCI Chemical

Product number: A1888
Product name: 2-Amino-4-methyl-3-nitropyridine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $24
Updated: 2025/07/31

TCI Chemical

Product number: A1888
Product name: 2-Amino-4-methyl-3-nitropyridine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $59
Updated: 2025/07/31

TRC

Product number: A616960
Product name: 2-Amino-4-methyl-3-nitropyridine
Packaging: 10g
Price: $970
Updated: 2021/12/16

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2-Amino-3-nitro-4-picoline Chemical Properties,Usage,Production

Chemical Properties

light yellow crystal powder

Uses

2-Amino-4-methyl-3-nitropyridine was used in the synthesis of 2-amino-5-hydroxy-4-methyl-3-nitropyridine, 2-amino-4-hydroxymethyl-3-nitropyridine and 2-amino-4-methyl-3-nitropyridine-1-oxide by undergoing biotransformation by Cunninghamella elegans ATCC 26269.

General Description

The crystal structure of 2-amino-4-methyl-3-nitropyridine was elucidated.

Synthesis

695-34-1

21901-40-6

6635-86-5

The general procedure for the synthesis of 2-amino-4-methyl-5-nitropyridine and 4-methyl-3-nitropyridin-2-amine from 2-amino-4-methylpyridine was carried out as follows: commercially available 2-amino-4-methylpyridine (Fluka, purity >99%) was used as starting material according to the method previously described by Talik and Talik [29]. This was done as follows: 25 g of 2-amino-4-methylpyridine was dissolved in 125 cm3 concentrated sulfuric acid (Fluka, 96%). The reaction mixture was cooled to 0°C under strong stirring by adding ice mixed with sodium chloride. Subsequently, 37.5 cm3 of nitric acid (Chempur, 65%, density = 1.4 g/cm3) was slowly added, keeping the reaction temperature below 10°C. The reaction mixture was stirred under continuous cooling for 1.5 hours, followed by standing at room temperature for 1 hour. Next, the reaction mixture was sequentially heated in a water bath at 40°C for half an hour, at 60-70°C for 1 hour and in a boiling water bath for half an hour. After completion of the reaction, the mixture was cooled to room temperature, poured into ice water and adjusted to a weakly basic pH with ammonia. the solid product was collected by vacuum filtration. Steam distillation was utilized to separate the two nitro isomers (3-nitro and 5-nitro isomers). The more volatile 3-nitro isomer (I) was first distilled and concentrated and dried to give the pure product (10 g). The residual 5-nitro isomer (III) was collected by filtration and recrystallized from water (initial addition of sulfuric acid and activated carbon to dissolve the compound and remove impurities). After neutralization, filtration and drying, about 15 g of 5-nitroisomer (III) was obtained. 2-Amino-4-methyl-3,5-dinitropyridine (II) was prepared from 2-amino-4-methyl-5-nitropyridine (III) using a similar method (nitration and rearrangement to dinitropyridine). The residue was purified by crystallization in water to give 2-amino-4-methyl-3-nitropyridine (I) (yield: 27%, 10 g, melting point 134 °C), 2-amino-4-methyl-3,5-dinitropyridine (II) (yield: 80%, 10.4 g, melting point 197 °C) and 2-amino-4-methyl-5-nitropyridine (III) (yield: 40%, 15 g (yield: 40%, 15g, melting point 218°C). Melting points were determined using a K?fler apparatus and the chemical composition of the compounds was verified by Carlo Erba Analyzer (model 1104).

References

[1] Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2012, vol. 96, p. 952 - 962
[2] Journal of the Chemical Society, 1954, p. 2448,2455
[3] Journal of the American Chemical Society, 1955, vol. 77, p. 3154
[4] Journal of Fluorine Chemistry, 2011, vol. 132, # 8, p. 541 - 547
[5] Journal of Molecular Structure, 2013, vol. 1043, p. 15 - 27

2-Amino-3-nitro-4-picoline Preparation Products And Raw materials

Raw materials

Preparation Products

N-(2-Amino-4-methylpyridin-3-yl)-2-chloropyridine-3-carboxamide

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View Lastest Price from 2-Amino-3-nitro-4-picoline manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Amino-3-nitro-4-picoline 6635-86-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-29

Henan Fengda Chemical Co., Ltd

Product: 2-Amino-3-nitro-4-picoline 6635-86-5
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Dideu Industries Group Limited

Product: 2-Amino-3-nitro-4-picoline 6635-86-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-26

6635-86-5, 2-Amino-3-nitro-4-picolineRelated Search:

2-Amino-3-nitro-4-picoline 2-AMINO-5-NITRO-3-PICOLINE,2-AMINO-5-NITRO-3-PICOLINE (2-AMINO-3-METHYL-5-NITROPYRIDINE) 2-AMINO-5-NITRO-6-PICOLINE,6-AMINO-3-NITRO-2-PICOLINE,2-AMINO-5-NITRO-6-PICOLINE (2-AMINO-6-METHYL-5-NITROPYRIDINE) 2-AMINO-5-FLUORO-3-NITRO-4-PICOLINE 2-AMINO-5-CHLORO-4-METHYL-3-NITROPYRIDINE 2-Amino-5-bromo-4-methyl-3-nitropyridine 6-AMINO-5-NITRO-2-PICOLINE,98%,6-AMINO-5-NITRO-2-PICOLINE,2-AMINO-3-NITRO-6-PICOLINE 2-AMINO-5-NITRO-4-PICOLINE,2-AMINO-5-NITRO-4-PICOLINE (2-AMINO-4-METHYL-5-NITROPYRIDINE) 6-AMINO-5-NITRO-3-PICOLINE,6-Amino-5-nitro-3-picoline, 98+%,2-AMINO-3-NITRO-5-PICOLINE 4-Methyl-3-nitropyridine Pyridine 3-Nitropyridine 2-Amino-3-nitro-4,6-dimethyl-5-bromopyridine 2-AMINO-5-CYANO-3-NITRO-4-PICOLINE METHYL-(4-METHYL-3-NITRO-PYRIDIN-2-YL)-AMINE 2-AMINO-3,5-BISNITRO-4-METHYLPYRIDINE 4,6-DIMETHYL-3-NITRO-PYRIDIN-2-YLAMINE 2-AMINO-5-METHOXY-3-NITRO-4-PICOLINE

4-Methyl-3-nitro-2-pyridinamine

2-Amino-4-methyl-3-nitropyridine,97%

4-METHYL-3-NITRO-PYRI

TIMTEC-BB SBB006636

2-AMINO-4-METHYL-3-NITROPYRIDINE

2-AMINO-3-NITRO-4-METHYLPYRIDINE

2-AMINO-3-NITRO-4-PICOLINE

4-METHYL-3-NITRO-PYRIDIN-2-YLAMINE

2-amin-3-nitro-4-methylpyridine

2-Amino-3-nitro-4-methoxypyridine

2-Amino-4-methy -5-nitropyridine

2-Amino-4-Mythyl-3-NitroPyridine

2-AMINO-3-NITRO-4-METHOXYPYRIDIN

2-PYRIDINAMINE, 4-METHYL-3-NITRO-

2-AMINO-3-NITRO-4-PICOLINE (2-AMINO-4-METHYL-3-NITROPYRIDINE)

3-Nitro-4-methyl-2-pyridinamine

3-Nitro-4-methylpyridine-2-amine

2-Amino-3-nitro-4-picoline,98%

4-methyl-3-nitropyridin-2-amine

2-AMino-4-Methyl-3-nitrop...

NSC 52453

2-Amino-4-methyl-3-nitropyridine 98%

2-Amino-4-methyl-3-nitropyridine &gt

6-methyl-3-nitropyridin-3-amine

2-Amino-3-nitro-4-picoline ISO 9001：2015 REACH

6635-86-5

6645-86-5

6635-85-6

AMINO

Pyridines

Heterocyclic Building Blocks

Building Blocks

Pyridines

Boronic Acid

Heterocycle-Pyridine series

amine |nitro-compound

Pyridine

Pyridine series

Amines

Aromatics

Heterocycles