Procarbazine hydrochloride

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Procarbazine hydrochloride

Product Name: Procarbazine hydrochloride
CAS No.: 366-70-1
Chemical Name: Procarbazine hydrochloride
Synonyms: PROCARBAZINE HCL;matulane;ibz;Mutulane;nsc-77213;nci-c01810;NSC-77213 HCl;natulanhydrochloride;ibenzmethyzinhydrochloride;PROCARBAZINE HYDROCHLORIDE
CBNumber: CB6678902
Molecular Formula: C12H20ClN3O
Formula Weight: 257.76
MOL File: 366-70-1.mol

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Procarbazine hydrochloride Property

Melting point:: 223°C
Density: 8.3 g/cm3
storage temp.: Inert atmosphere,2-8°C
solubility: DMSO: ≥18mg/mL
form: powder
color: white to tan
Water Solubility: >=10 g/100 mL at 21.5 ºC
Merck: 14,7758
BCS Class: 3/1
CAS DataBase Reference: 366-70-1(CAS DataBase Reference)
IARC: 2A (Vol. 26, Sup 7) 1987
EPA Substance Registry System: Procarbazine hydrochloride (366-70-1)

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Safety

Hazard Codes: T
Risk Statements: 45-61-22-68
Safety Statements: 53-36/37-45
WGK Germany: 3
RTECS: XS4725000
HS Code: 2928002500
Toxicity: LD50 orally in rats: 785 ±34 mg/kg (Goldenthal)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H341Suspected of causing genetic defects

H350May cause cancer

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0036
Product name: Procarbazine hydrochloride
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $97.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1565009
Product name: Procarbazine hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $393
Updated: 2024/03/01

TCI Chemical

Product number: P2550
Product name: Procarbazine Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 100mg
Price: $40
Updated: 2024/03/01

TCI Chemical

Product number: P2550
Product name: Procarbazine Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 500mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 16133
Product name: Procarbazine (hydrochloride)
Purity: ≥98%
Packaging: 50mg
Price: $32
Updated: 2024/03/01

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Procarbazine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Chemical Properties

Procarbazine is a white to pale yellow crystal- line powder with a slight odor.

Uses

Procarbazine hydrochloride USP is used to traet Hodgkin’s disease; non-Hodgkin’s lymphomas; lung cancer.

Uses

Antineoplastic.

Uses

Antineoplastic;DNA replication inhibitor

Definition

ChEBI: A hydrochloride obtained by combining procarbazine with one equivalent of hydrochloric acid. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaki g of DNA strands.

brand name

Matulane (Sigma-Tau).

General Description

White to pale yellow crystalline powder with a slight odor. Acid to litmus.

General Description

Procarbazine is available in 50-mg tablets for oral administrationin the treatment of Hodgkin’s (part of MOPP) andnon-Hodgkin’s disease, brain cancer, and mycosis fungoides.The major mechanisms of resistance appear to beenhanced activity of DNA-repair enzymes including enhancedO-6-alkylguanine DNA transferase (AGAT),which removes the methyl group from the O-6 of guanine.The agent is rapidly and completely absorbed after oral administrationand extensively metabolized in the liver togive azo-procarbazine followed by further oxidation tomethyldiazine and the aldehyde. The parent drug andmetabolites cross the blood-brain barrier. Elimination occursin the urine mostly as metabolites with an eliminationhalf-life of 1 hour. Myelosuppression is dose limiting, generallypresenting as thrombocytopenia that may be followedby leucopenia. Glucose-6-phosphate dehydrogenasedeficient patients may develop hemolytic anemia duringprocarbazine therapy. Other adverse effects include nausea,vomiting, hypersensitivity, flulike symptoms, amenorrhea,and azoospermia. Central nervous symptom effectsmay be seen, including lethargy, confusion, neuropathies,and seizure.

Air & Water Reactions

In the presence of moisture or in aqueous solution undergoes oxidation by atmospheric oxygen. Water soluble.

Reactivity Profile

Procarbazine hydrochloride is very sensitive to light. Stability is highest in aqueous acid and decreases with increasing pH. Degrades rapidly in alcoholic media and more slowly in aqueous media .

Fire Hazard

Flash point data for Procarbazine hydrochloride are not available; however, Procarbazine hydrochloride is probably combustible.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by an unspecified route. Moderately toxic by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl. Used as a chemotherapeutic agent.

Potential Exposure

Procarbazine is available in capsule form. The primary use of this drug is as an antineoplastic agent in the treatment of advanced Hodgkin’s disease, and oat-cell carcinoma of the lung. The hydrochloride com- pound is used in treatment. The FDA approved use of pro- carbazine hydrochloride in 1969 and indicated that the drug should be used as an adjunct to standard therapy. Possible exposure occurs during manufacture of the drug and direct exposure during its subsequent administration to patients. Some of the metabolites of procarbazine hydrochloride are both carcinostatic and carcinogenic.

Veterinary Drugs and Treatments

In veterinary medicine, procarbazine is used as part of MOPP protocols (mechlorethamine, vincristine, procarbazine, prednisone) to treat lymphomas in dogs and cats. It may be of benefit in treating granulomatous meningoencephalitis (GME) in dogs.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

Waste Disposal

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quanti- ties shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

Procarbazine hydrochloride Preparation Products And Raw materials

Raw materials

Sodium hydride N-Bromosuccinimide N,N-Dimethylformamide Methyl 4-methylbenzoate 1,4-Dioxane Hydrochloric acid Benzyl chloroformate Methylhydrazine Acetic acid

Preparation Products

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View Lastest Price from Procarbazine hydrochloride manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: Procarbazine hydrochloride 366-70-1
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-12-11

Hebei Chuanghai Biotechnology Co,.LTD

Product: Procarbazine Hydrochloride 366-70-1
Price: US $1000.00/kg
Min. Order: 10kg
Purity: 99 %
Supply Ability: 10000kg
Release date: 2024-08-21

Shaanxi Dideu Medichem Co. Ltd

Product: Procarbazine hydrochloride 366-70-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20t
Release date: 2024-06-18

366-70-1, Procarbazine hydrochloride Related Search:

Phenethyl alcohol DL-ALPHA-METHYLBENZYLAMINE Isopropyl-α-[2-methylhydrazino]-p-toluamide Carbobenzoxyhydrazide Methylparaben 4-Methylbenzyl chloride Cyclopropyl methyl ketone Chlorantraniliprole 2-(Trifluoromethyl)benzyl chloride 2-PHENYL-2-PROPANOL tert-Butylhydrazine hydrochloride Methyl acrylate Basic Violet 1 1,2-Dimethylhydrazine Dihydrochloride 3-Methyl-2-butanone Acetonitrile Methanol Topotecan hydrochloride

N-(1-methylethyl)-4-[(2-methylhydrazinyl)methyl]-benzamide,hydrochloride (1:1)

NSC-77213 HCl

N-(1-Methylethyl)-4-[(2-methylhydrazinyl)methyl]benzamide hydrochloride

Procarbazine hydrochloride, >=99%

Procarbazine hydrochloride (Matulane)

ibenzmethyzinhydrochloride

ibz

matulane

n-(1-methylethyl)-4-((2-methylhydrazino)methyl)-benzamidmonohydrochlorid

natulanhydrochloride

nci-c01810

n-isopropyl-alpha-(2-methylhydrazino)-p-toluamidehydrochloride

1-(p-isopropylcarbamoylbenzyl)-2-methylhydrazinehydrochloride

1-methyl-2-(p-isopropylcarbamoylbenzyl)hydrazinehydrochloride

1-methyl-2-p-(isopropylcarbamyol)benzohydrazinehydrochloride

2-(p-(isopropylcarbamoyl)benzyl)-1-methylhydrazinehydrochloride

chlorhydratede1-methyl2p(isopropylcarbamoyl)benzyl-hydrazine

ibenzmethyzinehydrochloride

n-isopropyl-alpha-(2-methylhydrazino)-p-toluamidhydrochloride

n-isopropyl-alpha-(2-methylhydrazino)-p-toluamidmonohydrochloride

n-isopropyl-p-(2-methylhydrazinomethyl)benzamidehydrochloride

nsc-77213

p-(n’-methylhydrazinomethyl)-n-isopropylbenzamidehydrochloride

PROCARBAZINE HCL

PROCARBAZINE HYDROCHLORIDE

Mutulane

N-Isopropyl-(2-methylhydrazino)-p-toluamide-Hydrochloride

N-ISOPROPYL-ALPHA-(2-METHYLHYDRAZINO)-PARA-TOLUAMIDE

n-(1-methylethyl)-4-((2-methylhydrazino)methyl)benzamide hydrochloride

Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]-, monohydrochloride

Procarbazine hydrochloride ,98%

Procarbazine Hydrochloride (200 mg)

4-[(methylhydrazo)methyl]-N-propan-2-ylbenzamide hydrochloride

N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide Hydrochloride

N-Isopropyl-4-((2-methylhydrazinyl)methyl)benzamide hydrochloride

Procarbazine HCl (NSC-77213)

TIANFU CHEM---Procarbazine hydrochloride

Procarbazine Hydrochloride (1565009)

366-70-1

156-2-23

C12H19N3OClH

C12H20ClN3O

C12H19N3OHCl

API

Matulane

Intermediates & Fine Chemicals

Pharmaceuticals

366-70-1