Sodium gualenate
Description Uses Mechanism of action- Product Name
- Sodium gualenate
- CAS No.
- 6223-35-4
- Chemical Name
- Sodium gualenate
- Synonyms
- Guai;SODIUM GUAIAZULENE SULFONATE;sodium gualenate;3-Sulfonate sodium salt;Azulene sulfonate sodium;Sodium guazulene sulfonate;Guaiazulenesulfonate sodium;guaiazulene / azulene powder;Sodium azulene sulphonate, 98%;Sodium gualenate, 10 mM in DMSO
- CBNumber
- CB6688455
- Molecular Formula
- C15H17NaO3S
- Formula Weight
- 300.35
- MOL File
- 6223-35-4.mol
Sodium gualenate Property
- Melting point:
- 98°C(lit.)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO : 30 mg/mL (99.88 mM)
- form
- powder to crystaline
- color
- Blue to Dark blue
- Merck
- 14,4554
- InChI
- InChI=1S/C15H18O3S.Na/c1-9(2)12-6-5-10(3)15-13(8-12)11(4)7-14(15)19(16,17)18;/h5-9H,1-4H3,(H,16,17,18);/q;+1/p-1
- InChIKey
- GEYJUFBPCGDENK-UHFFFAOYSA-M
- SMILES
- C12C(C)=CC=C(C(C)C)C=C1C(=CC=2S([O-])(=O)=O)C.[Na+]
Safety
- RTECS
- CO4826000
- HS Code
- 2908.99.1500
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S0976
- Product name
- Sodium 7-Isopropyl-1,4-dimethylazulene-3-sulfonate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $42
- Updated
- 2025/07/31
- Product number
- S0976
- Product name
- Sodium 7-Isopropyl-1,4-dimethylazulene-3-sulfonate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $164
- Updated
- 2025/07/31
- Product number
- J90078
- Product name
- Sodium 7-Isopropyl-1,4-dimethylazulene-3-sulfonate
- Packaging
- 250mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- API0028141
- Product name
- 1,4-DIMETHYL-7-ISOPROPYLAZULENE-3-SULFONATE SODIUM SALT
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $685.21
- Updated
- 2021/12/16
- Product number
- 38267
- Product name
- Sodiumgualenate,98%(HPLC)
- Purity
- 98%(HPLC)
- Packaging
- 5G
- Price
- $720.16
- Updated
- 2021/12/16
Sodium gualenate Chemical Properties,Usage,Production
Description
Sodium gualenate is unstable, it will decompose under light, air oxidation and high temperature environment, and it is easy to remove the sulfonic acid group. According to existing reports, it is common for sodium azulene sulfonate to contain half or one crystal water.
Uses
Sodium gualenate is an active ingredient of chamomile flowers, which has strong anti-pepsin, anti-inflammatory, antibacterial, anti-allergic, and promotion of mucosal metabolism. It is mainly used to study duodenal ulcer, gastric ulcer and gastritis.
Mechanism of action
Sodium gualenate inhibits the release of histamine from inflammatory cells through local direct action; increases the synthesis of prostaglandin E2 in the mucosa, promotes granulation formation and epithelial cell regeneration; and can reduce the activity of pepsin.
Uses
Sodium gualenate (Guaiazulenesulfonate sodium) is a hydrophilic derivative of guaiazulene with excellent anti-inflammatory and wound-healing effects mainly used for the treatment of duodenal ulcer, gastric ulcer and gastritis.
Synthesis
489-84-9
6223-35-4
(1) Preparation of sodium 3,8-dimethyl-5-isopropylchrysanthemum-1-sulfonate Under ice bath conditions, 4 mmol of guaiacol and 2 mL of acetic anhydride (Ac2O) were added to a 25 mL pear-shaped flask. Subsequently, a mixture of 1 mL of concentrated sulfuric acid (H2SO4) and 2 mL of acetic anhydride (Ac2O) was slowly added dropwise through a constant-pressure dropping funnel (with a drying tube fitted at the top). After the dropwise addition, the reaction mixture was stirred at room temperature for about 2 hours, during which the progress of the reaction was monitored by thin layer chromatography (TLC) until the feedstock completely disappeared. Upon completion of the reaction, the mixture solution was poured into 4 mL of water and the pH was adjusted to 8-9 by dropwise addition of sodium hydroxide (NaOH) solution.Subsequently, the mixture solution was cooled to promote the formation of a precipitate, filtration was carried out, and the precipitate was washed sequentially with cold water and petroleum ether, and was dried to give 1.05 g of a blue solid product. The yield was 87.5% and the melting point was 106-107 °C.
in vivo
Sodium gualenate has been frequently used for the treatment of human gastritis. Cytoprotection is defined as the main mechanism of Sodium gualenate to protect the mucosa of the stomach and the antipeptic actions in vivo have also been shown[2].
References
[1] Nakamichi K, et al. Stabilization of sodium guaiazulene sulfonate in granules for tableting prepared using a twin-screw extruder. Eur J Pharm Biopharm. 2003 Nov;56(3):347-54. DOI:10.1016/s0939-6411(03)00100-0
[2] Cao T, et al. Synthesis and Biological Evaluation of 3, 8-dimethyl-5-isopropylazulene Derivatives as Anti-gastric Ulcer Agent. Chem Biol Drug Des. 2016 Aug;88(2):264-71. DOI:10.1111/cbdd.12753
Sodium gualenate Preparation Products And Raw materials
Raw materials
Preparation Products
Sodium gualenate Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from Sodium gualenate manufacturers
- Product
- Sodium gualenate 6223-35-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%-102%
- Supply Ability
- 100KG
- Release date
- 2025-09-28
- Product
- Sodium gualenate 6223-35-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.5%min
- Supply Ability
- 200KG
- Release date
- 2025-09-12
- Product
- Sodium gualenate 6223-35-4
- Price
- US $10.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 99%
- Supply Ability
- 10 ton
- Release date
- 2025-08-22