3,6-DIHYDROXYXANTHONE

Product Name: 3,6-DIHYDROXYXANTHONE
CAS No.: 529-61-3
Chemical Name: 3,6-DIHYDROXYXANTHONE
Synonyms: Eyxanthone;IFLAB-BB F0349-4255;1,7-DIHYDROXYXANTHONE;3,6-DIHYDROXYXANTHONE;1,7-Dihydroxy-9H-xanthen-9-one;9H-Xanthen-9-one, 1,7-dihydroxy-
CBNumber: CB6698357
Molecular Formula: C13H8O4
Formula Weight: 228.2
MOL File: 529-61-3.mol

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3,6-DIHYDROXYXANTHONE Property

storage temp.: 2-8°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: powder
color: Yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM0304331
Product name: 1,7-DIHYDROXY-9H-XANTHEN-9-ONE
Purity: 95.00%
Packaging: 5MG
Price: $500.78
Updated: 2021/12/16

Arctom

Product number: CFN98879
Product name: Euxanthone
Purity: ≥98%
Packaging: 5mg
Price: $283
Updated: 2021/12/16

Crysdot

Product number: CD32001075
Product name: Euxanthone
Purity: 95+%
Packaging: 5mg
Price: $720
Updated: 2021/12/16

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3,6-DIHYDROXYXANTHONE Chemical Properties,Usage,Production

Uses

Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities[1][2][3].

Definition

ChEBI: A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1 and 7 and an oxo group at position 9. It has been isolated from Cratoxylum cochinchinense.

Synthesis Reference(s)

Synthetic Communications, 19, p. 1641, 1989 DOI: 10.1080/00397918908051061

in vivo

Euxanthone (40-80 mg/kg) could significantly decrease the number of metastatic nodules in lung tissue in a pulmonary metastasis model^[1].
Euxanthone (30-60 mg/kg; p.o.;once a day; for 7 days) treatment normalized Bnip3, Beclin1, Pink1, Parkin, p53, Bax, caspase-3, and LC3 II/I in bearing bilateral common carotid artery occlusion (BCCAO). Euxanthone modulates mitophagy and apoptosis induces by mitochondrial stress mediated by mitochondrial fragmentation^[2].

Animal Model:	Forty male ICR mice (20 g) induced cerebral ischemia and reperfusion^[2]
Dosage:	30 mg/kg, 60 mg/kg
Administration:	p.o.;once a day; for 7 days
Result:	Markedly attenuated BCCAO triggered mitochondrial stress and related breakdown.

References

[1] Xiaodong Chen, et al. Euxanthone Impairs the Metastatic Potential of Osteosarcoma by Reducing COX-2 Expression. Anat Rec (Hoboken). 2019 Aug;302(8):1399-1408. DOI:10.1002/ar.23992
[2] Wei Sun, et al. Euxanthone improves cognitive impairment by attenuating mitochondrial fragmentation and suppressing oxidative stress. Cent Eur J Immunol. 2021;46(4):446-455. DOI:10.5114/ceji.2021.111444
[3] aicheng Yuan, et al. Euxanthone Attenuates Aβ1-42-Induced Oxidative Stress and Apoptosis by Triggering Autophagy. J Mol Neurosci. 2018 Dec;66(4):512-523. DOI:10.1007/s12031-018-1175-2

3,6-DIHYDROXYXANTHONE Preparation Products And Raw materials

Raw materials

Preparation Products

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3,6-DIHYDROXYXANTHONE Suppliers

Canada 1 China 34 United Kingdom 1 United States 5 USA 1 Global 42

BioBioPha Co., Ltd.

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Amadis Chemical Company Limited

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Chengdu Push Bio-Technology Co., Ltd.

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View Lastest Price from 3,6-DIHYDROXYXANTHONE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 1,7-Dihydroxy-9H-xanthen-9-one 529-61-3
Price: US $0.00-0.00/KG
Min. Order: 5mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-06

529-61-3, 3,6-DIHYDROXYXANTHONERelated Search:

alpha-Terpineol beta-Sitosterol MOSLOFLAVONE Hydroxyecdysone alpha-Cyperone hydroxygenkwanin 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one Artemether beta-Eudesmol

3,6-DIHYDROXYXANTHONE

1,7-DIHYDROXYXANTHONE

1,7-Dihydroxy-9H-xanthen-9-one

Eyxanthone

9H-Xanthen-9-one, 1,7-dihydroxy-

IFLAB-BB F0349-4255

529-61-3

C13H8O4