ChemicalBook > CAS DataBase List > (S)-5-Hydroxymethyldihydrofuran-2-one

(S)-5-Hydroxymethyldihydrofuran-2-one

Product Name
(S)-5-Hydroxymethyldihydrofuran-2-one
CAS No.
32780-06-6
Chemical Name
(S)-5-Hydroxymethyldihydrofuran-2-one
Synonyms
5-(Hydroxymethyl)dihydro-2(3H)-furanone;(S)-(+)-γ-Hydroxymethyl-γ(S)-Gamma-Hydroxymethyl-Gamma;(S)-4-HYDROXYMETHYL BUTYROLACTONE;(5S)-5-(hydroxyMethyl)oxolan-2-one;(s)-γ-hydroxymethyl-γ-butyrolactone;(S)-5-Hydroxymethyldihydrofuran-2-on;(S)-(+)-G-HYDROXYMETHYL-G-BUTYROLACTONE;(S)-5-HYDROXYMETHYL-DIHYDRO-FURAN-2-ONE
CBNumber
CB6702069
Molecular Formula
C5H8O3
Formula Weight
116.12
MOL File
32780-06-6.mol
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(S)-5-Hydroxymethyldihydrofuran-2-one Property

Melting point:
72-74 °C
alpha 
56 º (c=3 in chloroform)
Boiling point:
110-115 °C/0.2 mmHg (lit.)
Density 
1.237 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.471(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
pka
14.12±0.10(Predicted)
form 
clear liquid
color 
Colorless to Almost colorless
optical activity
[α]20/D +56°, c = 3 in chloroform
BRN 
1680284
CAS DataBase Reference
32780-06-6(CAS DataBase Reference)
NIST Chemistry Reference
(S)-(+)-2',3'-dideoxyribonolactone(32780-06-6)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
23-24/25-37/39-26
WGK Germany 
3
HS Code 
29322090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
348902
Product name
(S)-(+)-Dihydro-5-(hydroxymethyl)-2(3H)-furanone
Purity
95%
Packaging
1g
Price
$226
Updated
2023/06/20
TCI Chemical
Product number
H0958
Product name
(S)-(+)-γ-Hydroxymethyl-γ-butyrolactone
Purity
>94.0%(GC)
Packaging
1g
Price
$114
Updated
2024/03/01
TCI Chemical
Product number
H0958
Product name
(S)-(+)-γ-Hydroxymethyl-γ-butyrolactone
Purity
>94.0%(GC)
Packaging
5g
Price
$504
Updated
2024/03/01
TRC
Product number
H973063
Product name
(S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one
Packaging
1g
Price
$65
Updated
2021/12/16
Matrix Scientific
Product number
119181
Product name
(S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one
Purity
95+%
Packaging
1g
Price
$72
Updated
2021/12/16
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(S)-5-Hydroxymethyldihydrofuran-2-one Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liqui

Uses

(S)-(+)-Dihydro-5-(hydroxymethyl)-2(3H)-furanone can be used as a chiral synthon to synthesize:

  • Potent nucleoside, acetylcholine, and (+)-muricatacin analogs.
  • Mevinic acids, which are LDL cholesterol-lowering agents.
  • Adenine based anti-HIV agent named β-F-ddA.

General Description

Dihydro-5-(hydroxymethyl)-2(3H)-furanone is a chiral building block widely used in the synthesis of many natural products and few biologically significant compounds like anti-HIV dideoxynucleosides. It is also used in the synthesis of optically active ligands.

(S)-5-Hydroxymethyldihydrofuran-2-one Preparation Products And Raw materials

Raw materials

Borane-methyl sulfide complex L-Glutamic acid Sodium nitrite Tetrahydrofuran Benzene Ethyl acetate Hydrochloric acid Methanol PETROLEUM ETHER

Preparation Products

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(S)-5-Hydroxymethyldihydrofuran-2-one Suppliers

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View Lastest Price from (S)-5-Hydroxymethyldihydrofuran-2-one manufacturers

Career Henan Chemical Co
Product
(S)-5-Hydroxymethyldihydrofuran-2-one 32780-06-6
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
150KG
Release date
2019-07-01

32780-06-6, (S)-5-Hydroxymethyldihydrofuran-2-oneRelated Search:

Tris(hydroxymethyl)nitromethane Tetrahydrofuran (Hydroxymethyl)urea methylol cellulose Tris(hydroxymethyl)aminomethane Furazolidone BETA-BUTYROLACTONE 2,5-Dihydrofuran Methyl 2-hydroxyethyl cellulose Dihydromyrcenol 2,3-Dihydrobenzofuran 2,3-Dihydrofuran 2-Methylfuran 2-Hydroxyethyl methacrylate CARBOXYMETHYLCELLULOSE SODIUM SALT Trimethylolpropane Gamma Butyrolactone (1S)-(-)-Camphanic acid

  • (S)-(+)-gamma-Hydroxymethyl-gamma-butyrolactone,97%
  • (S)-Gamma-Hydroxymethyl-Gamma
  • (S)-(+)-Dihydro-5-(hydroxymethyl)-2(3H)-furanone ,97%
  • (5S)-5-(HYDROXYMETHYL)-3,4,5-TRIHYDROFURAN-2-ONE
  • (5S)-(+)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one
  • (S)-(+)-4,5-Dihydro-5-hydroxymethyl-2(3H)-furanone (S)-(+)-5-Hydroxymethyltetrahydro-2-furanone
  • 5-Oxo-tetrahydro-furan-2-carboxylic acid ethyl ester
  • (5S)-5-(hydroxyMethyl)oxolan-2-one
  • 2(3H)-Furanone,dihydro-5-(hydroxyMethyl)-, (5S)-
  • (S)-(+)-Dihydro-5-(hydroxymethyl)-2(3H)-furanone 95%
  • (<i>S</i>)-(+)-&gamma
  • -Hydroxymethyl-&gamma
  • 5-(Hydroxymethyl)dihydro-2(3H)-furanone
  • (S)-(+)-DIHYDRO-5-(HYDROXYMETHYL)-2(3H)-FURANONE
  • (S)-(+)-DIHYDRO-5-(HYDROXYMETHYL)FURANONE
  • (S)-(+)-GAMMA-HYDROXYMETHYL-GAMMA-BUTYROLACTON
  • (S)-(+)-GAMMA-HYDROXYMETHYL-GAMMA-BUTYROLACTONE
  • (S)-GAMMA-HYDROXYMETHYL-GAMMA-BUTYROLACTONE
  • (S)-(+)-G-HYDROXYMETHYL-G-BUTYROLACTONE
  • (S)-(+)-4,5-DIHYDRO-5-HYDROXYMETHYL-2(3H)-FURANONE
  • (S)-4,5-DIHYDRO-5-HYDROXYMETHYL-2(3H)-FURANONE
  • (5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran
  • DIHYDRO-5-(HYDROXYMETHYL)-2(3H)-FURANONE (S-)
  • 2(3H)-FURANONE, DIHYDRO-5-(HYDROXYMETHYL)-,(S)
  • (S)-4-HYDROXYMETHYL BUTYROLACTONE
  • (S)-5-HYDROXYMETHYL-2-OXOTETRAHYDROFURAN
  • (S)-5-HYDROXYMETHYL-DIHYDRO-FURAN-2-ONE
  • (S)-(+)-5-HYDROXYMETHYL-GAMMA-BUTYROLACTONE
  • (S)-(+)-5-HYDROXYMETHYLTETRAHYDRO-2-FURANONE
  • (S)-5-Hydroxymethyldihydrofuran-2-on
  • (S)-γ-Hydroxymethyl-γ-butyrolactone, (S)-4,5-Dihydro-5-hydroxymethyl-2(3H)-furanone, (S)-5-Hydroxymethyl-2-oxotetrahydrofuran
  • (S)-4,5-Dihydro-5-hydroxymethyl-2(3H)-furanone, (S)-5-Hydroxymethyl-2-oxotetrahydrofuran
  • (S)-(+)-DIHYDRO-5-(HYDROXYMETHYL)-2(3H)- FURANONE, 95% (98% EE/GLC)
  • (S)-GAMMA-HYDROXYMETHYL-GAMMA-BUTYRO- &
  • (s)-γ-hydroxymethyl-γ-butyrolactone
  • (S)-(+)-5-HYDROXYMETHYL-GAMMA-BUTYROLACTONE 98%
  • (S)-(+)-γ-Hydroxymethyl-γ-butyrolactone&gt
  • (5S)-5-(Hydroxymethyl)dihydro-2(3H)-furanone
  • 32780-06-6
  • Asymmetric Synthesis
  • Chiral Building Blocks
  • Heterocyclic Building Blocks
  • Furans
  • chiral
  • Chiral Reagent