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(S)-5-Hydroxymethyldihydrofuran-2-one

Product Name
(S)-5-Hydroxymethyldihydrofuran-2-one
CAS No.
32780-06-6
Chemical Name
(S)-5-Hydroxymethyldihydrofuran-2-one
Synonyms
5-(Hydroxymethyl)dihydro-2(3H)-furanone;(S)-(+)-γ-Hydroxymethyl-γ(S)-Gamma-Hydroxymethyl-Gamma;(S)-4-HYDROXYMETHYL BUTYROLACTONE;(5S)-5-(hydroxyMethyl)oxolan-2-one;(s)-γ-hydroxymethyl-γ-butyrolactone;(S)-5-Hydroxymethyldihydrofuran-2-on;(S)-(+)-G-HYDROXYMETHYL-G-BUTYROLACTONE;(S)-5-HYDROXYMETHYL-DIHYDRO-FURAN-2-ONE
CBNumber
CB6702069
Molecular Formula
C5H8O3
Formula Weight
116.12
MOL File
32780-06-6.mol
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(S)-5-Hydroxymethyldihydrofuran-2-one Property

Melting point:
72-74 °C
alpha 
56 º (c=3 in chloroform)
Boiling point:
110-115 °C/0.2 mmHg (lit.)
Density 
1.237 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.471(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
pka
14.12±0.10(Predicted)
form 
clear liquid
color 
Colorless to Almost colorless
optical activity
[α]20/D +56°, c = 3 in chloroform
BRN 
1680284
CAS DataBase Reference
32780-06-6(CAS DataBase Reference)
NIST Chemistry Reference
(S)-(+)-2',3'-dideoxyribonolactone(32780-06-6)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
23-24/25-37/39-26
WGK Germany 
3
HS Code 
29322090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
348902
Product name
(S)-(+)-Dihydro-5-(hydroxymethyl)-2(3H)-furanone
Purity
95%
Packaging
1g
Price
$226
Updated
2023/06/20
TCI Chemical
Product number
H0958
Product name
(S)-(+)-γ-Hydroxymethyl-γ-butyrolactone
Purity
>94.0%(GC)
Packaging
1g
Price
$114
Updated
2024/03/01
TCI Chemical
Product number
H0958
Product name
(S)-(+)-γ-Hydroxymethyl-γ-butyrolactone
Purity
>94.0%(GC)
Packaging
5g
Price
$504
Updated
2024/03/01
TRC
Product number
H973063
Product name
(S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one
Packaging
1g
Price
$65
Updated
2021/12/16
Matrix Scientific
Product number
119181
Product name
(S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one
Purity
95+%
Packaging
1g
Price
$72
Updated
2021/12/16
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(S)-5-Hydroxymethyldihydrofuran-2-one Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liqui

Uses

(S)-(+)-Dihydro-5-(hydroxymethyl)-2(3H)-furanone can be used as a chiral synthon to synthesize:

  • Potent nucleoside, acetylcholine, and (+)-muricatacin analogs.
  • Mevinic acids, which are LDL cholesterol-lowering agents.
  • Adenine based anti-HIV agent named β-F-ddA.

General Description

Dihydro-5-(hydroxymethyl)-2(3H)-furanone is a chiral building block widely used in the synthesis of many natural products and few biologically significant compounds like anti-HIV dideoxynucleosides. It is also used in the synthesis of optically active ligands.

(S)-5-Hydroxymethyldihydrofuran-2-one Preparation Products And Raw materials

Raw materials

Borane-methyl sulfide complex L-Glutamic acid Sodium nitrite Tetrahydrofuran Benzene Ethyl acetate Hydrochloric acid Methanol PETROLEUM ETHER

Preparation Products

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(S)-5-Hydroxymethyldihydrofuran-2-one Suppliers

Americas 1 Belgium 2 China 104 Europe 1 France 2 Germany 3 India 6 Japan 3 Slovakia 1 Switzerland 3 United Kingdom 8 United States 32 Global 166
Interchim SA
Tel
--
Fax
--
Email
him@interchim.com
Country
France
ProdList
2725
Advantage
58
Interchim S.A.
Tel
--
Fax
--
Email
interchim@interchim.com
Country
France
ProdList
6302
Advantage
76
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View Lastest Price from (S)-5-Hydroxymethyldihydrofuran-2-one manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
(S)-5-Hydroxymethyldihydrofuran-2-one 32780-06-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2024-08-01
Career Henan Chemical Co
Product
(S)-5-Hydroxymethyldihydrofuran-2-one 32780-06-6
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
150KG
Release date
2019-07-01

32780-06-6, (S)-5-Hydroxymethyldihydrofuran-2-oneRelated Search:

Tris(hydroxymethyl)nitromethane Tetrahydrofuran (Hydroxymethyl)urea methylol cellulose Tris(hydroxymethyl)aminomethane Furazolidone BETA-BUTYROLACTONE 2,5-Dihydrofuran Methyl 2-hydroxyethyl cellulose Dihydromyrcenol 2,3-Dihydrobenzofuran 2,3-Dihydrofuran 2-Methylfuran 2-Hydroxyethyl methacrylate CARBOXYMETHYLCELLULOSE SODIUM SALT Trimethylolpropane Gamma Butyrolactone (1S)-(-)-Camphanic acid

  • (S)-(+)-gamma-Hydroxymethyl-gamma-butyrolactone,97%
  • (S)-Gamma-Hydroxymethyl-Gamma
  • (S)-(+)-Dihydro-5-(hydroxymethyl)-2(3H)-furanone ,97%
  • (5S)-5-(HYDROXYMETHYL)-3,4,5-TRIHYDROFURAN-2-ONE
  • (5S)-(+)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one
  • (S)-(+)-4,5-Dihydro-5-hydroxymethyl-2(3H)-furanone (S)-(+)-5-Hydroxymethyltetrahydro-2-furanone
  • 5-Oxo-tetrahydro-furan-2-carboxylic acid ethyl ester
  • (5S)-5-(hydroxyMethyl)oxolan-2-one
  • 2(3H)-Furanone,dihydro-5-(hydroxyMethyl)-, (5S)-
  • (S)-(+)-Dihydro-5-(hydroxymethyl)-2(3H)-furanone 95%
  • (<i>S</i>)-(+)-&gamma
  • -Hydroxymethyl-&gamma
  • 5-(Hydroxymethyl)dihydro-2(3H)-furanone
  • (S)-(+)-DIHYDRO-5-(HYDROXYMETHYL)-2(3H)-FURANONE
  • (S)-(+)-DIHYDRO-5-(HYDROXYMETHYL)FURANONE
  • (S)-(+)-GAMMA-HYDROXYMETHYL-GAMMA-BUTYROLACTON
  • (S)-(+)-GAMMA-HYDROXYMETHYL-GAMMA-BUTYROLACTONE
  • (S)-GAMMA-HYDROXYMETHYL-GAMMA-BUTYROLACTONE
  • (S)-(+)-G-HYDROXYMETHYL-G-BUTYROLACTONE
  • (S)-(+)-4,5-DIHYDRO-5-HYDROXYMETHYL-2(3H)-FURANONE
  • (S)-4,5-DIHYDRO-5-HYDROXYMETHYL-2(3H)-FURANONE
  • (5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran
  • DIHYDRO-5-(HYDROXYMETHYL)-2(3H)-FURANONE (S-)
  • 2(3H)-FURANONE, DIHYDRO-5-(HYDROXYMETHYL)-,(S)
  • (S)-4-HYDROXYMETHYL BUTYROLACTONE
  • (S)-5-HYDROXYMETHYL-2-OXOTETRAHYDROFURAN
  • (S)-5-HYDROXYMETHYL-DIHYDRO-FURAN-2-ONE
  • (S)-(+)-5-HYDROXYMETHYL-GAMMA-BUTYROLACTONE
  • (S)-(+)-5-HYDROXYMETHYLTETRAHYDRO-2-FURANONE
  • (S)-5-Hydroxymethyldihydrofuran-2-on
  • (S)-γ-Hydroxymethyl-γ-butyrolactone, (S)-4,5-Dihydro-5-hydroxymethyl-2(3H)-furanone, (S)-5-Hydroxymethyl-2-oxotetrahydrofuran
  • (S)-4,5-Dihydro-5-hydroxymethyl-2(3H)-furanone, (S)-5-Hydroxymethyl-2-oxotetrahydrofuran
  • (S)-(+)-DIHYDRO-5-(HYDROXYMETHYL)-2(3H)- FURANONE, 95% (98% EE/GLC)
  • (S)-GAMMA-HYDROXYMETHYL-GAMMA-BUTYRO- &
  • (s)-γ-hydroxymethyl-γ-butyrolactone
  • (S)-(+)-5-HYDROXYMETHYL-GAMMA-BUTYROLACTONE 98%
  • (S)-(+)-γ-Hydroxymethyl-γ-butyrolactone&gt
  • (5S)-5-(Hydroxymethyl)dihydro-2(3H)-furanone
  • 32780-06-6
  • Asymmetric Synthesis
  • Chiral Building Blocks
  • Heterocyclic Building Blocks
  • Furans
  • chiral
  • Chiral Reagent