4-Bromo-1-fluoro-2-nitrobenzene
- Product Name
- 4-Bromo-1-fluoro-2-nitrobenzene
- CAS No.
- 364-73-8
- Chemical Name
- 4-Bromo-1-fluoro-2-nitrobenzene
- Synonyms
- 2-fluoro-5-bromonitrobenzene;5-BROMO-2-FLUORONITROBENZENE;5-Bromo-2-fL;4-Bromo-1-fluoro-2-n;4-Bromo-2-nitrofluorobenzene;4-BROMO-1-FLUORO-2-NITROBENZENE;5-Bromo-2-fluoronitrobenzene98%;1-BROMO-4-FLUORO-3-NITROBENZENE;5-Bromo-2-fluoronitrobenzene 98%;Benzene, 4-bromo-1-fluoro-2-nitro-
- CBNumber
- CB6705914
- Molecular Formula
- C6H3BrFNO2
- Formula Weight
- 220
- MOL File
- 364-73-8.mol
4-Bromo-1-fluoro-2-nitrobenzene Property
- Melting point:
- 18-19 °C (lit.)
- Boiling point:
- 240-241 °C (lit.)
- Density
- 1.786 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.575(lit.)
- Flash point:
- >230 °F
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Difficult to mix.
- form
- Liquid After Melting
- color
- Clear yellow to brownish
- BRN
- 2329084
- InChI
- InChI=1S/C6H3BrFNO2/c7-4-1-2-5(8)6(3-4)9(10)11/h1-3H
- InChIKey
- UQEANKGXXSENNF-UHFFFAOYSA-N
- SMILES
- C1(F)=CC=C(Br)C=C1[N+]([O-])=O
- CAS DataBase Reference
- 364-73-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 36/37/39-26
- RIDADR
- 2810
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
- HS Code
- 29049090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 539112
- Product name
- 4-Bromo-1-fluoro-2-nitrobenzene
- Purity
- 96%
- Packaging
- 25g
- Price
- $175.75
- Updated
- 2025/07/31
- Product number
- B2075
- Product name
- 4-Bromo-1-fluoro-2-nitrobenzene
- Purity
- >96.0%(GC)
- Packaging
- 1g
- Price
- $21
- Updated
- 2025/07/31
- Product number
- B2075
- Product name
- 4-Bromo-1-fluoro-2-nitrobenzene
- Purity
- >96.0%(GC)
- Packaging
- 5g
- Price
- $57
- Updated
- 2025/07/31
- Product number
- B2075
- Product name
- 4-Bromo-1-fluoro-2-nitrobenzene
- Purity
- >96.0%(GC)
- Packaging
- 25g
- Price
- $192
- Updated
- 2025/07/31
- Product number
- B688683
- Product name
- 4-Bromo-1-fluoro-2-nitrobenzene
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
4-Bromo-1-fluoro-2-nitrobenzene Chemical Properties,Usage,Production
Chemical Properties
Clear yellow to brownish liquid after melting
Uses
Used in the synthesis of anti-inflammatory agents.1
Uses
4-Bromo-1-fluoro-2-nitrobenzene is used in the synthesis of anti-inflammatory agents.
General Description
4-Bromo-1-fluoro-2-nitrobenzene undergoes Sonogashira reaction with 2-fluoronitrobenzene to afford predominantly the bromo displacement product.
Synthesis
1493-27-2
364-73-8
General procedure for the synthesis of 4-bromo-1-fluoro-2-nitrobenzene from 1-fluoro-2-nitrobenzene: After completion of the reaction, the reaction mixture was cooled to room temperature and slowly poured into ice water. The product 2-fluoro-5-bromonitrobenzene in the aqueous phase was extracted with 200 mL of ethyl acetate, and the organic phases were combined and concentrated under reduced pressure to give a brown solid crude product. The crude product was purified by recrystallization from petroleum ether and analyzed by gas chromatography (GC) with a purity of 98%, and 227.1 g of the pure product was obtained after drying with a yield of 40.0%.
References
[1] Journal of the American Chemical Society, 2004, vol. 126, # 48, p. 15770 - 15776
[2] Patent: CN104530107, 2016, B. Location in patent: Paragraph 0026
4-Bromo-1-fluoro-2-nitrobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
4-Bromo-1-fluoro-2-nitrobenzene Suppliers
- Tel
- --
- Fax
- --
- chemcontrol@nextra.sk
- Country
- Slovakia
- ProdList
- 6700
- Advantage
- 60
View Lastest Price from 4-Bromo-1-fluoro-2-nitrobenzene manufacturers
- Product
- 4-Bromo-1-fluoro-2-nitrobenzene 364-73-8
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 10 ton
- Release date
- 2024-08-23
- Product
- 4-Bromo-1-fluoro-2-nitrobenzene 364-73-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-06-11
- Product
- 4-Bromo-1-fluoro-2-nitrobenzene 364-73-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.6%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18