Methyl Pyrazole-3-carboxylate

Product Name: Methyl Pyrazole-3-carboxylate
CAS No.: 15366-34-4
Chemical Name: Methyl Pyrazole-3-carboxylate
Synonyms: Albb-003661;TIMTEC-BB SBB000006;methyl 1H-pyrazole-;3- pyrazole carboxylate;Methyl 3-Pyrazolecarboxylate;Methyl Pyrazole-3-carboxylate;MethylPyrazole-3-carboxylate>Methyl 1H-pyrazol-3-carboxylate;METHYL 1H-PYRAZOLE-5-CARBOXYLATE;METHYL 1H-PYRAZOLE-3-CARBOXYLATE
CBNumber: CB6714824
Molecular Formula: C5H6N2O2
Formula Weight: 126.11
MOL File: 15366-34-4.mol

More

Less

Methyl Pyrazole-3-carboxylate Property

Melting point:: 141-142℃
Boiling point:: 271℃
Density: 1.275
Flash point:: 118℃
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in methanol.
form: powder to crystal
pka: 11.04±0.10(Predicted)
color: White to Almost white
λmax: 217nm(EtOH)(lit.)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22
HazardClass: IRRITANT
HS Code: 2933119000

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS009495
Product name: Methyl 1<I>H</I>-pyrazole-3-carboxylate
Purity: Aldrich<SUP>CPR</SUP>
Packaging: 100 mg
Price: $179
Updated: 2025/07/31

Sigma-Aldrich

Product number: CDS009495
Product name: Methyl 1H-pyrazole-3-carboxylate
Purity: AldrichCPR
Packaging: 100MG
Price: $174
Updated: 2024/03/01

TCI Chemical

Product number: M2444
Product name: Methyl Pyrazole-3-carboxylate
Purity: >98.0%(GC)
Packaging: 1g
Price: $71
Updated: 2025/07/31

TRC

Product number: P842565
Product name: 4-PyrazolecarboxylicAcidMethylEster
Packaging: 2.5g
Price: $130
Updated: 2021/12/16

Usbiological

Product number: 287142
Product name: 4-Pyrazolecarboxylic acid methyl ester
Packaging: 1g
Price: $418
Updated: 2021/12/16

More

Less

Methyl Pyrazole-3-carboxylate Chemical Properties,Usage,Production

Uses

The methyl ester derivative of 4-Pyrazolecarboxylic Acid (P842550) used in the preparation of androgen receptor (AR) antagonists as well as pyrazole nucleosides.

Uses

The methyl ester derivative of 4-Pyrazolecarboxylic Acid (P842550), Methyl Pyrazole-3-carboxylate can be used in the preparation of androgen receptor (AR) antagonists as well as pyrazole nucleosides.

Synthesis

67-56-1

1621-91-6

15366-34-4

To a stirred solution of 1H-pyrazole-3-carboxylic acid (2 g, 17.8 mmol, 1 eq.) in methanol (20 mL) was slowly added thionyl chloride (2.5 mL, 35.5 mmol, 2 eq.). The reaction mixture was stirred at 40 °C for 5 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent. The resulting residue was dissolved in dichloromethane (DCM) and washed with saturated aqueous sodium bicarbonate (NaHCO3). The organic layer was separated, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (petroleum ether/ethyl acetate=1/3, v/v) to afford methyl 1H-pyrazole-3-carboxylate (1.8 g, yield 79.6%) as a white solid.

References

[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 1, p. 159 - 166
[2] Russian Journal of General Chemistry, 2011, vol. 81, # 8, p. 1745 - 1746
[3] Patent: WO2018/11628, 2018, A1. Location in patent: Paragraph 00314
[4] Heterocycles, 1996, vol. 42, # 2, p. 517 - 523
[5] Journal fuer Praktische Chemie (Leipzig), 1935, vol. <2> 143, p. 259,273

Methyl Pyrazole-3-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Methyl Pyrazole-3-carboxylate Suppliers

Americas 1 Canada 1 China 172 Europe 1 Germany 2 India 3 Japan 1 Russia 1 Slovakia 1 United Kingdom 3 United States 25 Global 211

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Accela ChemBio Inc.

Tel: +1(858) 699-3322
Fax: +1(858) 876-1948
Email: marketing@accelachem.com
Country: United States
ProdList: 6024
Advantage: 65

AbaChemScene

Tel: 732-484-9848
Fax: 888-484-5008
Email: sales@chemscene.com
Country: United States
ProdList: 3982
Advantage: 60

Accela ChemBio Inc.

Tel: +1-858-6993322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
Country: United States
ProdList: 21193
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

TCI America

Tel: --
Fax: --
Email: sales@tciamerica.com
Country: United States
ProdList: 6909
Advantage: 75

Frontier Scientific, Inc.

Tel: --
Fax: --
Email: sales@frontiersci.com
Country: United States
ProdList: 6222
Advantage: 86

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Tractus USA LLC

Tel: --
Fax: --
Country: United States
ProdList: 227
Advantage: 60

Biofine International Inc.

Tel: --
Fax: --
Email: sales@biofineintl.com
Country: United States
ProdList: 653
Advantage: 38

Labseeker Inc

Tel: --
Fax: --
Email: marketing@labseeker.com
Country: United States
ProdList: 1495
Advantage: 55

Wilshire Chemical Company Inc.

Tel: --
Fax: --
Email: WilshrChem@AOL.COM
Country: United States
ProdList: 3498
Advantage: 58

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Aagile Labs Division of Tyger Scientific

Tel: --
Fax: --
Email: tygersci@yahoo.com
Country: United States
ProdList: 6568
Advantage: 68

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

Oakwood Products, Inc.

Tel: --
Fax: --
Email: sales@oakwoodchemical.com
Country: United States
ProdList: 6193
Advantage: 74

TimTec Corporation

Tel: --
Fax: --
Country: United States
ProdList: 1945
Advantage: 58

CGeneTech, Inc.

Tel: --
Fax: --
Email: qyu@cgenetech.com
Country: United States
ProdList: 959
Advantage: 30

Milestone PharmTech LLC

Tel: --
Fax: --
Email: sales@milestonepharmtech.com
Country: United States
ProdList: 1316
Advantage: 47

TimTec Corporation

Tel: --
Fax: --
Email: info@timtec.net
Country: United States
ProdList: 6891
Advantage: 68

More

Less

View Lastest Price from Methyl Pyrazole-3-carboxylate manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Methyl Pyrazole-3-carboxylate 15366-34-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-08

Honest Joy Holdings Limited

Product: Methyl 1H-pyrazole-5-carboxylate 15366-34-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.5%
Supply Ability: 100 tons
Release date: 2022-02-08

Career Henan Chemical Co

Product: METHYL 1H-PYRAZOLE-3-CARBOXYLATE 15366-34-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500kg
Release date: 2018-08-19

15366-34-4, Methyl Pyrazole-3-carboxylateRelated Search:

Dimethyl 1H-pyrazole-3,5-dicarboxylate 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE)-PYRAZOLE 5-Pyrazolecarboxylic acid 4-CYANOPYRAZOLE Pyrazole Pyrazole-3-boronic acid 1H-PYRAZOLE-3-CARBONITRILE DIETHYL 3,5-PYRAZOLEDICARBOXYLATE 1-ETHYL-3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER Ethyl 5-thien-2-yl-1H-pyrazole-3-carboxylate 5-TERT-BUTYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER ETHYL 1,5-DIMETHYL-1H-PYRAZOLE-3-CARBOXYLATE Ethyl pyrazole-3-carboxylate Ethyl 5-amino-4-cyano-1-phenyl-1H-pyrazole-3-carboxylate Ethyl 3-methyl-1H-pyrazole-5-carboxylate Ethyl 1-methyl-1H-pyrazole-5-carboxylate ,97% ETHYL 3-(TERT-BUTYL)-1-METHYL-1H-PYRAZOLE-5-CARBOXYLATE RARECHEM AL BF 1033

TIMTEC-BB SBB000006

METHYL 1H-PYRAZOLE-3-CARBOXYLATE

1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER

methyl 1H-pyrazole-3-carboxylate(SALTDATA: FREE)

Methyl Pyrazole-3-carboxylate

4-Pyrazolecarboxylic Acid Methyl Ester

Methyl 3-Pyrazolecarboxylate

Albb-003661

methyl 1H-pyrazole-

METHYL 1H-PYRAZOLE-5-CARBOXYLATE

3- pyrazole carboxylate

MethylPyrazole-3-carboxylate&gt

Methyl1H-pyrazole-3-carboxylate,97%

Pyrazole-3-carboxylic acid methyl ester

1H-Pyrazole-3-carboxylic acid, methyl ester (9CI, ACI)

Methyl 1H-pyrazol-3-carboxylate

15366-34-4

Aromatics

Heterocycles

Intermediates

pharmacetical