7-Nitro-1-tetralone
Application- Product Name
- 7-Nitro-1-tetralone
- CAS No.
- 40353-34-2
- Chemical Name
- 7-Nitro-1-tetralone
- Synonyms
- 7-NITROTETRALONE;7-NITRO-3,4-DIHYDR;7-NITRO-1-TETRALONE;7-NITROTETRA-1-LONE;7-nitro-1-tetrralone;7-Nitrotetralin-1-one;7-Nitrotetra-1-lone 98%;7-Nitro-1-tetralone,97%;3,4-dihydro-7-nitro-1(2h)-naphthalenon;7-NITRO-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE
- CBNumber
- CB6715669
- Molecular Formula
- C10H9NO3
- Formula Weight
- 191.18
- MOL File
- 40353-34-2.mol
7-Nitro-1-tetralone Property
- Melting point:
- 108-109°C
- Boiling point:
- 349.1±31.0 °C(Predicted)
- Density
- 1.322±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- color
- White to Orange to Green
- BRN
- 1570515
- CAS DataBase Reference
- 40353-34-2(CAS DataBase Reference)
- NIST Chemistry Reference
- 1(2H)-naphthalenone, 3,4-dihydro-7-nitro-(40353-34-2)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- N0945
- Product name
- 7-Nitro-1-tetralone
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $40
- Updated
- 2025/07/31
- Product number
- N0945
- Product name
- 7-Nitro-1-tetralone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $115
- Updated
- 2025/07/31
- Product number
- N565193
- Product name
- 7-Nitro-1-tetralone
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 4754-1-71
- Product name
- 7-Nitrotetra-1-lone
- Purity
- 95%
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- 5420AB
- Product name
- 7-Nitro-3,4-dihydronaphthalen-1(2H)-one
- Packaging
- 250mg
- Price
- $74
- Updated
- 2021/12/16
7-Nitro-1-tetralone Chemical Properties,Usage,Production
Application
7-Nitro-3,4-Dihydro-2H-1-naphthone is a ketone derivative that can be used as a pharmaceutical intermediate.
Chemical Properties
earthy yellow powder
Synthesis
529-34-0
40353-34-2
General procedure for the synthesis of 7-nitro-3,4-dihydro-2H-1-naphthalenone from 1-tetralone: Concentrated sulfuric acid (60 mL) was cooled to 0 °C in an ice bath. 1-Tetrahydronaphthalenone (8 g, 54.7 mmol) was added with stirring, and then potassium nitrate (6 g, 59.3 mmol, 1.08 eq.) dissolved in concentrated sulfuric acid (18 mL) was slowly added dropwise through a dropping funnel, controlling the reaction temperature to no more than 15 °C. The reaction was carried out at a controlled temperature of 15 °C. The reaction was completed with the addition of potassium nitrate (6 g, 59.3 mmol, 1.08 eq.). After the dropwise addition was completed, the reaction mixture was continued to be stirred for 1 hour. The reaction was quenched by pouring the reaction solution into crushed ice, the precipitate was collected by filtration and washed with distilled water. After drying, recrystallization was carried out through a solvent mixture of ethanol/water (1:1) to give 7-nitro-3,4-dihydro-2H-1-naphthalenone (8.5 g, 81% yield) as a light yellow solid with a melting point of 104-106 °C. The product was analyzed by infrared spectroscopy (IR, film) showing characteristic absorption peaks located at 1675 cm?1, 1500 cm?1 and 1340 cm?1. The nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 400 MHz, CDCl3) data are as follows: δ 2.18-2.25 (2H, m, CH2), 2.75 (2H, t, J = 6.8 Hz, CH2), and 3.10 (2H, t, J = 6.1 Hz, CH2), 7.45 (1H, d, J = 8.4 Hz, ArH), 8.30 (1H, dd, J = 2.4 Hz, 8.4 Hz, ArH), 8.86 (1H, d, J = 2.4 Hz, ArH).
References
[1] Patent: WO2004/87124, 2004, A1. Location in patent: Page/Page column 47-48
[2] European Journal of Medicinal Chemistry, 2014, vol. 71, p. 237 - 249
[3] Tetrahedron Letters, 1994, vol. 35, # 38, p. 7061 - 7064
[4] Justus Liebigs Annalen der Chemie, 1927, vol. 451, p. 53
[5] Journal of the Chemical Society. Perkin transactions 1, 1969, vol. 10, p. 1376 - 1378
7-Nitro-1-tetralone Preparation Products And Raw materials
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View Lastest Price from 7-Nitro-1-tetralone manufacturers
- Product
- 7-Nitro-1-tetralone 40353-34-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%minHPLC
- Supply Ability
- 50kgs/month
- Release date
- 2021-11-17
- Product
- 7-Nitro-1-tetralone 40353-34-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-25