3,5-Dimethoxyphenylboronic acid

Product Name: 3,5-Dimethoxyphenylboronic acid
CAS No.: 192182-54-0
Chemical Name: 3,5-Dimethoxyphenylboronic acid
Synonyms: 3,5-DimethoxyphenyL;3,5-DIMETHOXYBENZENEBORONIC ACID;AKOS BRN-0893;5-DiMethoxyphenylboronic acid;3,5-DIMETHOXYPHENYLBORONIC ACID;B-(3,5-dimethoxyphenyl)boronic acid;3,5-DIMETHOXYPHENYLBORONIC ACID 99%;3,5-Dimethoxyphenylboronic acid ,98%;3,5-Dimethoxyphenylboronic acid >=95%;Boronic acid, B-(3,5-dimethoxyphenyl)-
CBNumber: CB6716893
Molecular Formula: C8H11BO4
Formula Weight: 181.98
MOL File: 192182-54-0.mol

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3,5-Dimethoxyphenylboronic acid Property

Melting point:: 202-207 °C
Boiling point:: 371.6±52.0 °C(Predicted)
Density: 1.19±0.1 g/cm3(Predicted)
Flash point:: 81℃
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in methanol.
pka: 7.67±0.10(Predicted)
form: powder to crystal
color: White to Light yellow to Light orange
CAS DataBase Reference: 192182-54-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
WGK Germany: 3
Hazard Note: Irritant/Keep Cold
HazardClass: IRRITANT, KEEP COLD
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 715271
Product name: 3,5-Dimethoxyphenylboronic acid
Purity: ≥95%
Packaging: 1g
Price: $16.45
Updated: 2025/07/31

Sigma-Aldrich

Product number: 715271
Product name: 3,5-Dimethoxyphenylboronic acid
Purity: ≥95%
Packaging: 5g
Price: $121
Updated: 2025/07/31

TCI Chemical

Product number: D3513
Product name: 3,5-Dimethoxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 1g
Price: $33
Updated: 2025/07/31

TCI Chemical

Product number: D3513
Product name: 3,5-Dimethoxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 5g
Price: $91
Updated: 2025/07/31

TCI Chemical

Product number: D3513
Product name: 3,5-Dimethoxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 25g
Price: $301
Updated: 2025/07/31

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3,5-Dimethoxyphenylboronic acid Chemical Properties,Usage,Production

Chemical Properties

Gray to white solid

Uses

3,5-Dimethoxyphenylboronic acid is a useful reagent for palladium-catalyst and Suzuki-Miyaura cross coupling reactions.

Uses

Reactant for:

Palladium-catalyzed coupling reactions
Preparation of benzopyranone derivatives as positive GABAA receptor modulators
Preparation of aryl alkenes via three-component coupling catalyzed by palladium
Suzuki-Miyaura coupling
Rhodium catalyzed cyanation with N-cyano-N-phenyl-p-methylbenzenesulfonamide
Preparation of bisphosphonate inhibitors of human farnesyl pyrophosphate synthase

Uses

suzuki reaction

Synthesis

5419-55-6

20469-65-2

192182-54-0

1. Synthesis of 3,5-dimethoxyphenylboronic acid: After cooling the flame-dried reaction vessel under argon protection, 3,5-dimethoxybromobenzene (3 g, 13.82 mmol) and anhydrous tetrahydrofuran (36 ml) were added. The mixture was stirred until a clarified solution was formed. Subsequently, the reaction mixture was cooled to -78 °C and maintained at this temperature for 15 minutes. n-Butyllithium (10.92 ml, 2.1 M hexane solution) was slowly added and the reaction mixture continued to be stirred at -78 °C for 30 minutes. Then, triisopropyl borate (5.2 g, 27.64 mmol) was added dropwise and the reaction was continuously stirred at -78°C for 2 hours. After completion of the reaction, it was slowly warmed up to room temperature and acidified with 2 M sulfuric acid solution to pH 2. The reaction mixture was extracted with ethyl acetate, the organic phases were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by recrystallization from petroleum ether to give 3,5-dimethoxyphenylboronic acid in 92% yield.

References

[1] Patent: WO2008/118802, 2008, A1. Location in patent: Page/Page column 25-26

3,5-Dimethoxyphenylboronic acid Preparation Products And Raw materials

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Preparation Products

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View Lastest Price from 3,5-Dimethoxyphenylboronic acid manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3,5-Dimethoxyphenylboronic acid 192182-54-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3,5-Dimethoxyphenylboronic acid 192182-54-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Hebei shuoxi biotechnology co. LTD

Product: (3,5-dimethoxyphenyl)boronic acid 192182-54-0
Price: US $80.00/g
Min. Order: 10g
Purity: 99.8%
Supply Ability: 10tons
Release date: 2020-04-10

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3,5-DimethoxyphenyL

3,5-Dimethoxyphenylboronic Acid (contains varying amounts of Anhydride)

3,5-Dimethoxyphenylboronic acid, (contains various amounts of anhydride)

3,5-Dimethoxyphenylboronic acid ,98%

3,5-Dimethoxyphenylboronic Acid, (Contains Various Amounts Of Anhydr

B-(3,5-dimethoxyphenyl)boronic acid

5-DiMethoxyphenylboronic acid

3,5-DIMETHOXYPHENYLBORONIC ACID

3,5-DIMETHOXYBENZENEBORONIC ACID

AKOS BRN-0893

Boronic acid, B-(3,5-dimethoxyphenyl)-

3,5-Dimethoxyphenylboronic acid >=95%

3,5-DIMETHOXYPHENYLBORONIC ACID 99%

192182-54-0

C8H11O4B

B (Classes of Boron Compounds)

Boronic Acids

blocks

BoronicAcids

Heterocyclic Compounds

Boronic Acid