ChemicalBook > CAS DataBase List > 2-(2-Hydroxyethyl)pyridine

2-(2-Hydroxyethyl)pyridine

Product Name
2-(2-Hydroxyethyl)pyridine
CAS No.
103-74-2
Chemical Name
2-(2-Hydroxyethyl)pyridine
Synonyms
2-(Pyridin-2-yl)ethan-1-ol;2-PYRIDINEETHANOL;2-ETHANOLPYRIDINE;PYRIDINE-2-ETHANOL;2-PYRIDYLETHANOL;2-Pyridinethanol;2-Pyridineethonl;2-Pyridien ethanol;P-nitrochlorobenzen;2-(2-PYRIDYL)ETHANOL
CBNumber
CB6723385
Molecular Formula
C7H9NO
Formula Weight
123.15
MOL File
103-74-2.mol
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2-(2-Hydroxyethyl)pyridine Property

Melting point:
-8--7°C
Boiling point:
114-116 °C/9 mmHg (lit.)
Density 
1.093 g/mL at 25 °C (lit.)
vapor pressure 
1.16-14.1Pa at 25℃
refractive index 
n20/D 1.537(lit.)
Flash point:
199 °F
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Soluble in Chloroform (Slightly), Methanol (Slightly).
form 
Liquid
pka
14.49±0.10(Predicted)
color 
Clear yellow to brown
PH
8-9 (100g/l, H2O, 20℃)
Water Solubility 
soluble
Sensitive 
Hygroscopic
BRN 
111205
LogP
0.38
CAS DataBase Reference
103-74-2(CAS DataBase Reference)
NIST Chemistry Reference
2-Pyridineethanol(103-74-2)
EPA Substance Registry System
2-Pyridineethanol (103-74-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
WGK Germany 
2
RTECS 
UT2970450
F 
3
TSCA 
Yes
HS Code 
29333999
Hazardous Substances Data
103-74-2(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
128643
Product name
2-Pyridineethanol
Purity
98%
Packaging
5g
Price
$58.4
Updated
2025/07/31
Sigma-Aldrich
Product number
128643
Product name
2-Pyridineethanol
Purity
98%
Packaging
100g
Price
$67
Updated
2025/07/31
TCI Chemical
Product number
H0246
Product name
2-Pyridineethanol
Purity
>98.0%(GC)(T)
Packaging
25mL
Price
$34
Updated
2025/07/31
TCI Chemical
Product number
H0246
Product name
2-Pyridineethanol
Purity
>98.0%(GC)(T)
Packaging
500mL
Price
$274
Updated
2025/07/31
Sigma-Aldrich
Product number
128643
Product name
2-Pyridineethanol
Purity
98%
Packaging
500g
Price
$281.4
Updated
2025/07/31
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2-(2-Hydroxyethyl)pyridine Chemical Properties,Usage,Production

Chemical Properties

clear yellow to brown liquid

Uses

2-Pyridineethanol is a metabolite of the anti-vertigo drug Betahistine (B324000).

Uses

2-(2-Hydroxyethyl)pyridine is a metabolite of the anti-vertigo drug Betahistine. It acts as a reagent for protection of the 5'-phosphate of nucleotides as 2-pyridylethyl (Pet) esters. It is used for carboxyl protection of amino acids. It is also used to cleave such groups as Boc and Fmoc, and also to hydrogenolysis. It was used to prepare mononuclear nickel(II) acetate.

General Description

2-(2-pyridyl)ethanol derivatives react with the aryl and alkenyl chlorides (palladium-catalyzed reactions) that result in the substitution of the chloro moieties with a 2-pyridylmethyl group.

Synthesis

4377-33-7

50-00-0

103-74-2

The general procedure for the synthesis of 2-hydroxyethylpyridine from 2-chloromethylpyridine and formaldehyde is as follows: a two-necked Schlenk flask equipped with a magnetic stirring bar and a septum is heated under high vacuum with a hot air gun (ca. 400 °C) for 10 minutes. After cooling to room temperature, the flask was rinsed with argon (3 times). Zinc powder (654 mg, 2.0 equiv, 10.0 mmol) and THF (20 mL) were added sequentially. 1,2-dibromoethane (5 mol%) was added and the reaction mixture was heated to boiling. After cooling to room temperature, chlorotrimethylsilane (1 mol %) was added and the mixture was heated again to boiling. The flask was cooled to room temperature again, a solution of 2-chloromethylpyridine (633 mg, 5.0 mmol, 1 eq.) in THF (10 mL) was added and heated at 70 °C for 2 hours and then cooled to room temperature. Paraformaldehyde (450 mg, 3.0 eq, 15.0 mmol) was slowly added at room temperature and the flask was heated at 70 °C again for 6 hours. The reaction solution was cooled to room temperature and saturated NH4Cl solution was added. The phases were separated and the aqueous layer was extracted with ethyl acetate (100 mL). The organic layers were combined, washed sequentially with water (20 mL) and brine (10 mL) and dried over Na2SO4. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography using cyclohexane or cyclohexane/ethyl acetate as eluent to give 2-hydroxyethylpyridine (510 mg, 83%) as a colorless liquid.

References

[1] Synthetic Communications, 2017, vol. 47, # 10, p. 968 - 974

2-(2-Hydroxyethyl)pyridine Preparation Products And Raw materials

Raw materials

2- (2- hydroxyethyl) pyridine

Preparation Products

Betahistine 2-Vinylpyridine
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View Lastest Price from 2-(2-Hydroxyethyl)pyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-(2-Hydroxyethyl)pyridine 103-74-2
Price
US $49.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2025-06-16
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
2-(2-Hydroxyethyl)pyridine 103-74-2
Price
US $58.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-05-22
Shaanxi Dideu New Materials Co. Ltd
Product
2-(2-Hydroxyethyl)pyridine 103-74-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2024-11-08

103-74-2, 2-(2-Hydroxyethyl)pyridineRelated Search:

5-Amino-2-methylpyridine 2-(Hydroxymethyl)pyridine Sodium isethionate Clopidol 2,5-Dimethylpyridine Hydroxyethyl starch Pyridine 2-(2-Aminoethylamino)ethanol 2-(Ethylamino)ethanol Ethyl acetate Ethanol 2-(METHYLSULFONYL)ETHANOL 2-Chloro-5-chloromethylpyridine 2,6-Lutidine Hydroxyethyl Cellulose 4-Chlorobenzhydrol 2-Vinylpyridine N-Methyl-N,N-bis(2-pyridylethyl)amine

  • 2-ETHANOLPYRIDINE
  • 2-(B-HYDROXYETHYL)PYRIDINE
  • 2-(2-hydroxyethyl)-pyridin
  • 2-(2-Pyridinyl)ethanol
  • 2-(alpha-pyridyl)ethanol
  • 2-PYRIDINEETHANOL
  • 2-PYRIDYLETHANOL
  • 2-PYRIDIN-2-YL-ETHANOL
  • 2-(2'-HYDROXYETHYL)PYRIDINE
  • 2-(2-HYDROXYETHYL)PYRIDINE
  • 2-(2-PYRIDYL)ETHANOL
  • PYRIDINE-2-ETHANOL
  • Betahistine Impurity 2（Betahistine EP Impurity B）
  • 2-(beta-hydroxyethyl)pyridine
  • 2-(beta-Hydroxyethyl)-pyridine
  • P-nitrochlorobenzen
  • 2-Carboxyethylpyridine
  • 2-Pyridien ethanol
  • 2-(Pyridin-2-yl)ethan-1-ol
  • HYDROXYETHYLPYRIDINE
  • 2-(HYDROXYETHYL)PYRIDINE
  • 2-(2-Hydroxyethyl)pyridine, 2-(2-Pyridyl)ethanol
  • 2-Pyridin-2-ylethano
  • 2-(2-Hydroxyethyl)pyridine ,99%
  • 2-Pyridineethanol ,98%
  • 2-(2-Hydroxyethyl)pyridine, 98.5%
  • 2-(2-Hydroxyethyl)pyridine, 99% 5GR
  • 2-(2-PYRIDYL)ETHANOL FOR SYNTHESIS
  • 2-Pyridineethanol 98%
  • Betahistine Impurity B
  • Betahistine EP Impurity B
  • PYRIDINE-2-ETHANOL,98PCT MIN
  • 2-(Pyridin-2-yl)ethanol (2-(2-Hydro
  • Betahistine EP Impurity B (2-(2-Hydroxyethyl)pyridine)
  • 2-Pyridineethanol&gt
  • 2-(2-Hydroxyethyl)pyridine ISO 9001：2015 REACH
  • 2-Pyridinethanol
  • 2-Pyridineethanol (6CI, 7CI, 8CI, 9CI, ACI)
  • Betahistine Dihydrochloride Impurity B
  • Betahistine Dihydrochloride EP Impurity B
  • 2-Pyridineethonl
  • 2-(Pyridin-2-yl)ethanol (2-(2-Hydroxyethyl)pyridine)
  • 103-74-2
  • ALCOHOL
  • Building Blocks
  • C7 and C8
  • Heterocyclic Building Blocks
  • Pyridines
  • Aromatics, Heterocycles, Intermediates, Metabolites & Impurities
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Amino Acid Derivatives
  • Pyridine
  • bc0001