Prednisolone phosphate sodium

ChemicalBook > CAS DataBase List > Prednisolone phosphate sodium

Prednisolone phosphate sodium

Product Name: Prednisolone phosphate sodium
CAS No.: 125-02-0
Chemical Name: Prednisolone phosphate sodium
Synonyms: PREDNISOLONE SODIUM PHOSPHATE;PREDNISONE SODIUM PHOSPHATE;codelsol;Pediapred;hydeltrasol;Prednisolone sodium phosphate CRS;optival;predsol;Ak-pred;Dojilon
CBNumber: CB6725349
Molecular Formula: C21H27Na2O8P
Formula Weight: 484.39
MOL File: 125-02-0.mol

Less

Prednisolone phosphate sodium Property

Melting point:: >197°C (dec.)
alpha: D25 +102.5°
storage temp.: Inert atmosphere,Room Temperature
solubility: Freely soluble in water, very slightly soluble in ethanol (96 per cent).
form: Solid
color: White to Off-White
λmax: 243nm(MeOH)(lit.)
Merck: 14,7721
Stability:: Hygroscopic
CAS DataBase Reference: 125-02-0(CAS DataBase Reference)
EPA Substance Registry System: Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11.beta.)- (125-02-0)

Less

Safety

WGK Germany: 3
RTECS: TU4153300
HS Code: 2937290000

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2816
Product name: Prednisolone Sodium Phosphate
Purity: certified reference material, pharmaceutical secondary standard
Packaging: 500MG
Price: $170
Updated: 2024/03/01

Sigma-Aldrich

Product number: P2810000
Product name: Prednisolone sodium phosphate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: p2810000
Price: $153
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1557000
Product name: Prednisolone sodium phosphate
Packaging: 500mg
Price: $436
Updated: 2024/03/01

TCI Chemical

Product number: D3918
Product name: Disodium Prednisolone 21-Phosphate
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $297
Updated: 2024/03/01

Cayman Chemical

Product number: 15933
Product name: Prednisolone Phosphate (sodium salt)
Purity: ≥98%
Packaging: 1g
Price: $49
Updated: 2024/03/01

Less

Prednisolone phosphate sodium Chemical Properties,Usage,Production

Description

Prednisolone is a synthetic analog of the natural glucocorticoid corticosterone that has anti-inflammatory and immunsuppressive actions. It avidly binds both glucocorticoid and mineralocorticoid receptors (K_is = 2.4 and 37 nM). Prednisolone Phosphate, prepared as the sodium salt, is a water-soluble ester of the poorly soluble parent molecule, prednisolone. It is rapidly hydrolyzed in vivo to the parent molecule when administered intravenously. In addition, when given orally, prednisolone phosphate is more readily absorbed than prednisolone, resulting in a higher effective blood concentration of prednisolone.

Chemical Properties

White or almost white, hygroscopic, crystalline powder.

Originator

Hydeltrasol, MSD ,US ,1957

Uses

Prednisolone Sodium is a synthetic corticosteroid; metabolically interconvertible with prednisone.

Uses

antiinflammatory

Definition

ChEBI: Prednisolone sodium phosphate is an organic sodium salt of prednisolone phosphate. It is an ophthalmology drug used for the treatment of short-term inflammatory eye conditions and helps relieve inflammation, redness and irritation of the eyes. It has a role as an ophthalmology drug, an anti-inflammatory agent, a glucocorticoid receptor agonist, a prodrug and an anti-allergic agent. It is an organic sodium salt and a glucocorticoid. It contains a prednisolone phosphate(2-).

Manufacturing Process

Preparation of Prednisolone 21-Methanesulfonate: Seventy liters of dry pyridine and 7.5 kg of prednisolone are charged to a 30-gallon jacketed glasslined still. The mixture is agitated until complete solution is obtained. About 40 liters of pyridine are distilled at high vacuum while maintaining the batch temperature below 40°C. The solution is cooled to 0°C, and 2.2 liters of methanesulfonyl chloride are charged. The batch temperature is maintained between 0°C and +3°C during charging of the methanesulfonyl chloride. An atmosphere of flowing nitrogen is maintained in the still, and the mixture isagitated during the last stages of the addition. The mixture is then aged for one hour, and 15 gallons of ice water are added cautiously to the still while maintaining the temperature between 0° and 5°C.
The still contents are then transferred to a jacketed kettle equipped with an agitator, and 62 kg of cracked ice in 15 gallons of deionized water are added. The batch is aged one hour and a solution of 2 liters of concentrated (37%) hydrochloric acid in 4 gallons of deionized water is added. The batch is centrifuged and the centrifuge cake washed free of pyridine with deionized water. The centrifuge cake is then vacuum-dried at 50°C to a moisture content of about 1%, which requires about 3 days of drying. Yield about 7.77 kg (92%), according to US Patent 2,932,657.
Preparation of Prednisolone 21-Iodide: To a 30-gallon jacketed glass-lined still 64.5 lb (31.0 liters) of dimethylformamide are charged by vacuum. The still contents are agitated as 7.74 kg of dry (less than 1% moisture) prednisolone 21-methanesulfonate are charged. Then 4.02 kg of sodium iodide are charged. The still contents are heated to 57° to 60°C by means of a steam jacket and held at this temperature for 30 minutes. The batch is cooled to 35°C and 12 gallons of deionized water are added at the rate of about 1 gallon per minute. In the event the solution becomes cloudy, addition of water is interrupted and the mixture agitated for five minutes before resumption of water addition. After all of the water is added, the batch is transferred to a 50 gallon kettle equipped with agitator and an additional 16.7 gallons of deionized water are added. The batch is cooled to 0° to 5°C and aged for one hour. The batch is filtered and the filter cake washed and vacuum dried at 30° to 35°C to a moisture content of less than 1%. Yield about 7.95 kg (96%), according to US Patent 2,932,657.
Preparation of Prednisolone 21-Disodium Phosphate: Acetonitrile (50.0 ml) containing phosphoric acid (90%; 1.0 ml) was treated with triethylamine (3.0 ml) and the solution added to 11β,17α-dihydroxy-21-iodopregna-1,4-diene-3,20dione (1.0 gram; powdered). The mixture was refluxed for 2.75 hours and the solvent was then evaporated under reduced pressure to give a yellow oil. The oil was taken up in methanol (25 ml) and titrated to pH 10.9 with sodium hydroxide in methanol (N) using a pH meter. The precipitate was filtered off and the filtrate evaporated to a gum under reduced pressure. The gum was taken up in methanol (5 ml), filtered through filter paper and acetone (100 ml) was added to the filtrate. The precipitate was filtered off, washed with acetone and dried at 100°C/1 mm for 0.75 hour giving a pale yellow solid, prednisolone disodium phosphate (0.74 gram), which was completely soluble in water, according to US Patent 2,936,313.

brand name

Hydeltrasol (Merck); Inflamase (Novartis); Metreton (Schering); Orapred (BioMarin); Pediapred (UCB); Predair (Pharmafair).

Therapeutic Function

Glucocorticoid

Prednisolone phosphate sodium Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Prednisolone phosphate sodium Suppliers

Americas 1 Belgium 2 Brazil 2 China 223 Czech Republic 1 Europe 3 France 3 Germany 3 India 63 Italy 5 Japan 1 Malaysia 1 Singapore 1 South Korea 2 Spain 1 Ukraine 1 United Kingdom 7 United States 50 Global 370

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14055
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Protheragen-ING

Tel: +16313385890
Email: info@protheragen-ing.com
Country: United States
ProdList: 3868
Advantage: 58

TargetMol Chemicals Inc.

Tel: +8613564774135
Email: zijue.cai@tsbiochem.com
Country: United States
ProdList: 19885
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

United States Biological

Tel: --
Fax: --
Email: sales@advtechind.com
Country: United States
ProdList: 6075
Advantage: 58

CarboMer, Inc.

Tel: --
Fax: --
Email: sales@carbomer.com
Country: United States
ProdList: 4026
Advantage: 67

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6962
Advantage: 56

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

International Specialty Chemicals & Pharmaceuticals, Inc. (ISC&P)

Tel: --
Fax: --
Email: info@ischem.com
Country: United States
ProdList: 77
Advantage: 58

Alkano Chemicals, Inc

Tel: --
Fax: --
Country: United States
ProdList: 53
Advantage: 58

Rochem International Inc.

Tel: --
Fax: --
Email: gcadioli@rochemintl.com
Country: United States
ProdList: 80
Advantage: 58

Interchem Corporation USA

Tel: --
Fax: --
Email: esa@interchem.com
Country: United States
ProdList: 469
Advantage: 58

Ceres Chemical Co., Inc.,

Tel: --
Fax: --
Country: United States
ProdList: 14
Advantage: 58

Camphor Technologies Inc.

Tel: --
Fax: --
Country: United States
ProdList: 148
Advantage: 58

Lalilab, Inc

Tel: --
Fax: --
Email: info@lalilab.com
Country: United States
ProdList: 69
Advantage: 58

ACIC FINE CHEMICALS INC

Tel: --
Fax: --
Email: sales@acic.com
Country: United States
ProdList: 25
Advantage: 58

Spectrum Chemical Mfg. Corp.

Tel: --
Fax: --
Email: marketing@spectrumchemical.com
Country: United States
ProdList: 3113
Advantage: 60

OChem Incorporation

Tel: --
Fax: --
Email: sales@ocheminc.com
Country: United States
ProdList: 6501
Advantage: 60

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

SANOFI CHIMIE

Tel: --
Fax: --
Email: johnd@sanofi.com
Country: United States
ProdList: 34
Advantage: 58

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

TCI America

Tel: --
Fax: --
Email: sales@tciamerica.com
Country: United States
ProdList: 6909
Advantage: 75

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

AlliChem, LLC

Tel: --
Fax: --
Email: sales@allichemllc.com
Country: United States
ProdList: 6516
Advantage: 60

Olinax Inc.

Tel: --
Fax: --
Email: info@olinax.com
Country: United States
ProdList: 404
Advantage: 50

ChemService Inc.

Tel: --
Fax: --
Country: United States
ProdList: 6379
Advantage: 68

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

Hawkins, Inc.

Tel: --
Fax: --
Email: ir@hawkinsinc.com
Country: United States
ProdList: 235
Advantage: 68

Hawkins, Inc.

Tel: --
Fax: --
Email: ir@hawkinsinc.com
Country: United States
ProdList: 212
Advantage: 30

ACIC Fine Chemicals Inc.

Tel: --
Fax: --
Email: sales@acic.com
Country: United States
ProdList: 492
Advantage: 48

Advance Scientific & Chemical

Tel: --
Fax: --
Email: sales@advance-scientific.com
Country: United States
ProdList: 6419
Advantage: 71

2A PharmaChem USA

Tel: --
Fax: --
Email: sales@2apharmachem.com
Country: United States
ProdList: 6137
Advantage: 39

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

AK Scientific, Inc.

Tel: --
Fax: --
Email: sales@aksci.com
Country: United States
ProdList: 6347
Advantage: 65

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

Sciencelab.com, Inc.

Tel: --
Fax: --
Email: accounting@sciencelab.com
Country: United States
ProdList: 4159
Advantage: 82

Anantco

Tel: --
Fax: --
Country: United States
ProdList: 13
Advantage: 59

American Custom Chemicals Corporation

Tel: --
Fax: --
Email: sales@acccorporation.com
Country: United States
ProdList: 6820
Advantage: 51

BOSCHE SCIENTIFIC, LLC

Tel: --
Fax: --
Email: Sales@BoscheSci.com
Country: United States
ProdList: 6477
Advantage: 55

LKT Laboratories, Inc.

Tel: --
Fax: --
Email: info@lktlabs.com
Country: United States
ProdList: 2164
Advantage: 64

Spectrum Chemicals & Laboratory Products

Tel: --
Fax: --
Email: sales@spectrumchemical.com
Country: United States
ProdList: 6699
Advantage: 77

Steraloids Inc.

Tel: --
Fax: --
Email: sales@steraloids.com
Country: United States
ProdList: 2357
Advantage: 68

ChemPacific Corporation

Tel: --
Fax: --
Email: sales@chempacific.com
Country: United States
ProdList: 6891
Advantage: 51

Less

View Lastest Price from Prednisolone phosphate sodium manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Prednisolone phosphate sodium 125-02-0
Price: US $1.00/Kg/Bag
Min. Order: 1KG
Purity: 96.0%-103.0%,EP9
Supply Ability: 200kg/month
Release date: 2021-06-01

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Prednisolone phosphate sodium 125-02-0
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 96.0%～103.0%; EP9.0
Supply Ability: 1000kg/month
Release date: 2021-06-03

Wuhan Haorong Biotechnology Co.,Ltd

Product: Prednisolone phosphate sodium 125-02-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5000
Release date: 2023-07-27

125-02-0, Prednisolone phosphate sodiumRelated Search:

Tylosin phosphate Triethyl phosphate Sodium polyphosphate Solvent Red 43 Trisodium phosphate Zinc phosphate Pentasodium triphosphate hexhydrate Calcium phosphate Ethylenediaminetetraacetic acid disodium salt Disodium succinate Prednisolone Methylprednisolone Sodium Phosphate Monobasic Monohydrate Methylprednisolone acetate Prednisolone-21-acetate Meprednisone Prednisone Prednisolone sodium succinate

SODIUM PREDNISOLONE-21-PHOSPHATE

PREDNISONE SODIUM PHOSPHATE

prednisolone phosphate sodium

PREDNISOLONE SODIUM PHOSPHATE

PREDNISOLONE 21-PHOSPHATE, DISODIUM SALT

(11beta)-

4-diene-3,20-dione,11-beta,17,21-trihydroxy-pregna-21-(dihydrogenphosphat

codelsol

e),disodiumsalt

hydeltrasol

inflamase

optival

phortisolone

prednesol

prednisolone21-phosphatedisodium

prednisolonedisodiumphosphate

predsol

predsolan

pregna-1,4-diene-3,20-dione,11,17-dihydroxy-21-(phosphonooxy)-,disodiumsalt,

prozorin

sodiumprednisolonephosphate

solucort

Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11.beta.)-

PREDNISOLONESODIUMPHOSPHATE,USP

Ak-pred

Dojilon

Hefasolon

Metreton

Pediapred

Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11b)- (9CI)

Pregna-1,4-diene-3,20-dione, 11b,17,21-trihydroxy-, 21-(dihydrogen phosphate), disodium salt (7CI, 8CI)

Pregna-1,4-diene-3,20-dione, 11b,17,21-trihydroxy-, 21-phosphate, disodium salt (6CI)

Solu-Predalone

Prednisolone 21-sodium phosphate

Prednisolone phospha

prednisolone 21-(disodium phosphate)

PrednisoloneSodiumPhosphateBp/Usp/Ep

Prednisolone Series Base 50-24-8 / Phosphate

Prednisolone Sodium Phosphate (500 mg)

Prednisolone SodiuM Phosphate USP/EP

Prednisolone Phosphate (sodium salt)

disodium [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate

)-6,9-Difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-3-oxoandrosta-1,4-diene-17-carboxylic Acid

-Hydroxy-17,20:20,21-bis(methylenedioxy)pregn-4-en-3-one Nitrite

)-21-Chloro-9-fluoro-11-hydroxy-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione

)-9-Fluoro-11,21-dihydroxy-16-methyl-pregna-1,4,16-triene-3,20-dione

17,21-Trihydroxy-16&alpha

-methyl-pregn-4-ene-3,20-dione 21-Acetate

17,20&beta

21-Tetrahydroxypregna-1,4-dien-3-one 21-Acetate

-Hydroxy-3-oxo-androsta-1,4-diene-17&beta

)-17-(Acetyloxy)-11-[4-(dimethylamino)phenyl]-3-hydroxy-19-norpregna-1,3,5(10)-trien-20-one-d3

21-Tetrahydroxypregna-1,4-diene-3,20-dione-d3

)-11-Hydroxy-16-methyl-17,21-bis(1-oxoacetoxy)-pregna-1,4-diene-3,20-dione

17,21-Trihydroxy-3,20-dioxo-cyclic-18,11-hemiacetal Pregn-4-en-18-al Triacetate

-methyl-17,20:20,21-bis(methylenedioxy)-pregn-4-en-3-one

)-11,17,21-Trihydroxy-pregna-1,4,8-triene-3,20-dione

-Hydroperoxy Dienogest