ChemicalBook > CAS DataBase List > Boc-N-Methyl-L-isoleucine

Boc-N-Methyl-L-isoleucine

Product Name
Boc-N-Methyl-L-isoleucine
CAS No.
52498-32-5
Chemical Name
Boc-N-Methyl-L-isoleucine
Synonyms
BOC-MELLE-OH;BOC-MEILE-OH;Boc-N-Me-Ile;BOC-L-MELLE-OH;BOC-L-MEILE-OH;BOC-N-ME-ILE-OH;Boc-N-Me-L-Ile-OH;BOC-N-ME-ISOLEUCINE;BOC-N-METHYL-L-ILE-OH;Boc-N-ethyl-L-Isoleucine
CBNumber
CB6747521
Molecular Formula
C12H23NO4
Formula Weight
245.32
MOL File
52498-32-5.mol
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Boc-N-Methyl-L-isoleucine Property

Boiling point:
338.2±21.0 °C(Predicted)
Density 
1.053±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
pka
4.05±0.22(Predicted)
form 
Solid
color 
White to off-white
optical activity
Consistent with structure
BRN 
4251277
InChI
InChI=1S/C12H23NO4/c1-7-8(2)9(10(14)15)13(6)11(16)17-12(3,4)5/h8-9H,7H2,1-6H3,(H,14,15)/t8-,9-/m0/s1
InChIKey
HTBIAUMDQYXOFG-IUCAKERBSA-N
SMILES
C(O)(=O)[C@H]([C@@H](C)CC)N(C(OC(C)(C)C)=O)C
CAS DataBase Reference
52498-32-5(CAS DataBase Reference)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B601123
Product name
BOC-N-Methyl-L-isoleucine
Packaging
100mg
Price
$75
Updated
2021/12/16
Usbiological
Product number
264713
Product name
Boc-N-methyl-L-isoleucine
Packaging
2g
Price
$343
Updated
2021/12/16
Chem-Impex
Product number
02655
Product name
Boc--methyl-L-isoleucine
Purity
≥ 99% (TLC)
Packaging
1G
Price
$31.1
Updated
2021/12/16
Activate Scientific
Product number
AS88065
Product name
Boc-N-methyl-L-isoleucine
Purity
95% ee
Packaging
1g
Price
$56
Updated
2021/12/16
Chem-Impex
Product number
02655
Product name
Boc-N-methyl-L-isoleucine,99%(TLC)
Purity
99%(TLC)
Packaging
5G
Price
$104.38
Updated
2021/12/16
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Boc-N-Methyl-L-isoleucine Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

Boc-N-methyl-L-isoleucine (Boc-N-Me-Ile-OH) is a peptide products and can be used as a precursor in organic synthesis and pharmaceuticals[1].

Synthesis

13139-16-7

74-88-4

53462-50-3

N-(tert-butoxycarbonyl)-L-isoleucine (1.24 g, 5.4 mmol, 1.0 eq.) was dissolved in 35 mL of tetrahydrofuran (THF), cooled to 0 °C and sodium hydride (60% dispersed in mineral oil; 0.64 g, 16.1 mmol, 3.0 eq.) was added slowly. Iodomethane (6.1 g, 42 mmol, 8.0 eq.) was then added and the reaction mixture was stirred at room temperature for 24 hours. After completion of the reaction, ether was added and the organic layer was washed twice with deionized water. The combined aqueous layers were adjusted to pH 3 with citric acid and extracted with ethyl acetate (EtOAc). The combined organic phases were washed sequentially with sodium thiosulfate (Na2S2O3) solution and saturated brine and dried over anhydrous sodium sulfate (Na2SO4). The solvent was removed under reduced pressure to afford (2S,3S)-2-((tert-butoxycarbonyl)(methyl)amino)-3-methylpentanoic acid as a colorless oil (1.18 g, 90% yield). The product was characterized by infrared spectroscopy (IR), nuclear magnetic resonance hydrogen spectroscopy (1H NMR), nuclear magnetic resonance carbon spectroscopy (13C NMR), and high-resolution mass spectrometry (HRMS) to confirm the correct structure. The specific optical rotation [α]20D was +2.6 (c 1.8, acetic acid).

References

[1] KazuhiroIrie, et al. Isolation and biosynthesis of (?)-indolactam I, a new congener of indole alkaloid tumor promoter teleocidins. Tetrahedron Letters, 1990, 7337-7340.

Boc-N-Methyl-L-isoleucine Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-N-Methyl-L-isoleucine Suppliers

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View Lastest Price from Boc-N-Methyl-L-isoleucine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Boc-N-methyl-L-isoleucine 52498-32-5
Price
US $2.00-5.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
g-kg-tons
Release date
2025-07-10
Shanghai Getian Industrial Co., LTD
Product
Boc-N-Methyl-L-isoleucine 52498-32-5
Price
US $23.00-19.00/box
Min. Order
1box
Purity
99%
Supply Ability
10000box
Release date
2024-05-11

52498-32-5, Boc-N-Methyl-L-isoleucineRelated Search:

Methyl acrylate Kresoxim-methyl N-Carbobenzyloxyglycine Bensulfuron methyl Methylparaben METHYL THIOPHENE-2-CARBOXYLATE 1,1'-Carbonyldiimidazole L-Isoleucine Boc-Aib-OH Thiophanate-methyl BOC-ILE-OH 1/2H2O BOC-GLY-LEU-OH Methyl FMOC-ARG(ME,PBF)-OH Parathion-methyl Carbonyl iron powder Methyl bromide DIMETHYL-P-NITROPHENYLPHOSPHATE

  • BOC-N-METHYL-L-ILE-OH
  • BOC-N-METHYL-L-ISOLEUCINE
  • BOC-N-ME-ILE-OH
  • BOC-N-ME-ISOLEUCINE
  • BOC-MEILE-OH
  • BOC-MELLE-OH
  • BOC-N-ALPHA-METHYL-L-ISOLEUCINE
  • BOC-L-MEILE-OH
  • BOC-L-MELLE-OH
  • N-ALPHA-T-BOC-N-ALPHA-METHYL-L-ISOLEUCINE
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-ISOLEUCINE
  • N-ALPHA-T-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-ISOLEUCINE
  • N-ALPHA-T-BUTOXYCARBONYL-N-ALPHA-METHYL-L-ISOLEUCINE
  • N-ALPHA-TERT-BUTYLOXYCABONYL-N-ALPHA-METHYL-L-ISOLEUCINE
  • N-alpha-t-Butyloxycarbonyl-N-alpha-methy-L-isoleucine
  • NALPHA-tert-Butoxycarbonyl-N-methyl-L-isoleucine
  • N-tert-Butyloxycarbonyl-N-methyl-L-isoleucine
  • (2S,3S)-2-(tert-butoxycarbonyl(methyl)amino)-3-methylpentanoic acid
  • (2S,3S)-3-methyl-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]pentanoic acid
  • Boc-N-Me-Ile
  • Boc-N-Me-L-Ile-OH
  • Boc-N-methyl-L-isoleucine≥ 99% (TLC)
  • 3-methyl-2-[methyl-[(2-methylpropan-2-yl)oxy-oxomethyl]amino]pentanoic acid
  • N-tert-Butoxycarbonyl-N-methylisoleucine
  • L-Isoleucine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-
  • (2S,3S)-3-methyl-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]pentanoicaci
  • Boc-N-Methyl-L-isoleucine USP/EP/BP
  • Boc-N-ethyl-L-Isoleucine
  • Boc-N-α-Methyl-L-isoleucine
  • Boc-N-Methyl-L-isoLeu-OH
  • 52498-32-5
  • Specialty Synthesis
  • N-Methyl Amino Acids
  • Peptide Synthesis
  • Unnatural Amino Acid Derivatives
  • amino acids
  • Amino Acid Derivatives