ETHYL MANDELATE Property

Melting point:

35.5°C

alpha 

[α]D20 -0.1～+0.2° (neat)

Boiling point:

253-255 °C(lit.)

Density 

1.115 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.512(lit.)

Flash point:

>230 °F

storage temp. 

Refrigerator

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly)

form 

Oil

color 

Colourless

CAS DataBase Reference

4358-88-7(CAS DataBase Reference)

Safety

Safety Statements 

24/25

WGK Germany 

2

RTECS 

OO7397000

HS Code 

29172090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

ETHYL MANDELATE Chemical Properties,Usage,Production

Chemical Properties

Appearance :white solid or liquid

Uses

Ethyl Mandelate is used as a reagent in the synthesis of several organic compounds including that of volatile methylsiloxanes which have the potential to be a more environmentally sustainable alternative as solvents in chemical synthesis to non-polar organic solvents. It was found to act as a substrate for (S)-mandelate dehydrogenase which is a flavin mononucleotide dependent enzyme that oxidises (S)-mandelate to benzoylformate.

Definition

ChEBI: Ethyl hydroxy(phenyl)acetate is the ethyl ester of mandelic acid. It is an ethyl ester and a secondary alcohol. It is functionally related to a mandelic acid.

Synthesis Reference(s)

Journal of the American Chemical Society, 107, p. 3981, 1985 DOI: 10.1021/ja00299a038
The Journal of Organic Chemistry, 49, p. 3241, 1984 DOI: 10.1021/jo00191a048