BENACTYZINE HYDROCHLORIDE
- Product Name
- BENACTYZINE HYDROCHLORIDE
- CAS No.
- 57-37-4
- Chemical Name
- BENACTYZINE HYDROCHLORIDE
- Synonyms
- cedad;fobex;Amizyl;Amisil;amisyl;amizil;cafron;ea2092;katron;parpon
- CBNumber
- CB2154541
- Molecular Formula
- C20H26ClNO3
- Formula Weight
- 363.88
- MOL File
- 57-37-4.mol
BENACTYZINE HYDROCHLORIDE Property
- Melting point:
- 177-179 °C(lit.)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly, Heated), Methanol (Slightly)
- form
- Solid
- color
- Crystals from Me2CO
- Merck
- 14,1029
- CAS DataBase Reference
- 57-37-4(CAS DataBase Reference)
- EPA Substance Registry System
- Benzeneacetic acid, .alpha.-hydroxy-.alpha.-phenyl-, 2-(diethylamino)ethyl ester, hydrochloride (57-37-4)
Safety
- Hazard Codes
- T
- Risk Statements
- 23/24/25
- Safety Statements
- 36/37/39-45
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- DD2800000
- HS Code
- 2922.50.4000
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Toxicity
- LD50 orl-rat: 184 mg/kg TXAPA9 1,42,59
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B0053
- Product name
- Benactyzine Hydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $172
- Updated
- 2024/03/01
- Product number
- B119600
- Product name
- Benactyzine Hydrochloride
- Packaging
- 5g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- C6667
- Product name
- Benactyzine Hydrochloride
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-8073
- Product name
- Benactyzine Hydrochloride
- Purity
- 99.69%
- Packaging
- 100mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- C6667
- Product name
- Benactyzine Hydrochloride
- Packaging
- 200mg
- Price
- $95
- Updated
- 2021/12/16
BENACTYZINE HYDROCHLORIDE Chemical Properties,Usage,Production
Originator
Suavitil,Merck Sharp and Dohme,US,1957
Uses
Benactyzine Hydrochloride is an antagonist of acetylcholine in the central and peripheral nervous system. Benactyzine Hydrochloride is used as an antispasmodic.
Manufacturing Process
114 parts of ethyl benzilate, 175 parts of β-diethylaminoethanol and 0.2 part of metallic sodium were placed in a flask attached to a total-reflux variable take-off fractionating column. The pressure was reduced to 100 mm and heat was applied by an oil bath the temperature of which was slowly raised to 90°C. During three hours of heating 17 parts of ethanol distilled (35.5°C). When the distillation of the ethanol became slow, the bath temperature was raised to 120°C. When the vapor temperature indicated distillation of the amino alcohol the take off valve was closed and the mixture was refluxed for one hour. At the end of this period the vapor temperature had dropped and two more parts of ethanol were distilled, The remaining aminoalcohol was slowly distilled for three hours. The pressure was then reduced to 20 mm and the remainder of the aminoalcohol distilled at 66°C. During the reaction the color of the solution changed from yellow to deep red. The residue was dissolved in 500 parts of ether, washed once with dilute brine, and three times with water, dried over sodium sulfate and finally dried over calcium sulfate. 500 parts of a saturated solution of HCl in absolute ether was added and the resulting precipitate filtered. Dry HCl gas was passed into the filtrate to a slight excess and the precipitate again filtered. The combined precipitates were washed with cold acetone. The 106 parts of product was purified by recrystallization from acetone as fine white crystals which melt at 177°- 178°C.
Therapeutic Function
Tranquilizer; Anticholinergic
Safety Profile
Poison by ingestion, intraperitoneal, subcutaneous, intradermal, and intravenous routes. Human systemic effects by ingestion of very small amounts: toxic psychosis. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NO, and HCl
BENACTYZINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BENACTYZINE HYDROCHLORIDE manufacturers
- Product
- Benactyzine Hydrochloride 57-37-4
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-06
- Product
- BENACTYZINE HYDROCHLORIDE 57-37-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 0.999
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-03
- Product
- Benactyzine Hydrochloride 57-37-4
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-09