Benactyzine
- Product Name
- Benactyzine
- CAS No.
- 302-40-9
- Chemical Name
- Benactyzine
- Synonyms
- Benactyzin;benactyzine;Benactyzine USP/EP/BP;Flamprop-methyl Impurity 8;Diethylaminoethyl benzilate;IVQOFBKHQCTVQV-UHFFFAOYSA-N;2-Diethylaminoethyl benzilate;Benzilic acid, 2-(diethylamino)ethyl ester;Benactyzine (base and/or unspecified salts);Diphenylglycolic acid 2-(diethylamino)ethyl ester
- CBNumber
- CB0854797
- Molecular Formula
- C20H25NO3
- Formula Weight
- 327.42
- MOL File
- 302-40-9.mol
Benactyzine Property
- Melting point:
- 51°
- Boiling point:
- 465.31°C (rough estimate)
- Density
- 1.1392 (rough estimate)
- refractive index
- 1.5614 (estimate)
- storage temp.
- 2-8°C
- pka
- 11.31±0.29(Predicted)
- NIST Chemistry Reference
- Benactyzine(302-40-9)
Safety
- Hazard Codes
- T
- Risk Statements
- 23/24/25
- Safety Statements
- 36/37/39-45
- Hazardous Substances Data
- 302-40-9(Hazardous Substances Data)
- Toxicity
- human,TDLo,intramuscular,100ug/kg (0.1mg/kg),SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE,"Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents," National Research Council, 3 vols., Washington, DC, National Academy Press, 1982-85Vol. 1, Pg. L1, 1982.
N-Bromosuccinimide Price
- Product number
- API0008980
- Product name
- BENACTYZINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.93
- Updated
- 2021/12/16
Benactyzine Chemical Properties,Usage,Production
Originator
Suavitil,Merck Sharp and Dohme,US,1957
Definition
ChEBI: 2-hydroxy-2,2-diphenylacetic acid 2-(diethylamino)ethyl ester is a diarylmethane.
Manufacturing Process
114 parts of ethyl benzilate, 175 parts of β-diethylaminoethanol and 0.2 part of metallic sodium were placed in a flask attached to a total-reflux variable take-off fractionating column. The pressure was reduced to 100 mm and heat was applied by an oil bath the temperature of which was slowly raised to 90°C. During three hours of heating 17 parts of ethanol distilled (35.5°C). When the distillation of the ethanol became slow, the bath temperature was raised to 120°C. When the vapor temperature indicated distillation of the amino alcohol the take off valve was closed and the mixture was refluxed for one hour. At the end of this period the vapor temperature had dropped and two more parts of ethanol were distilled, The remaining aminoalcohol was slowly distilled for three hours. The pressure was then reduced to 20 mm and the remainder of the aminoalcohol distilled at 66°C. During the reaction the color of the solution changed from yellow to deep red. The residue was dissolved in 500 parts of ether, washed once with dilute brine, and three times with water, dried over sodium sulfate and finally dried over calcium sulfate. 500 parts of a saturated solution of HCl in absolute ether was added and the resulting precipitate filtered. Dry HCl gas was passed into the filtrate to a slight excess and the precipitate again filtered. The combined precipitates were washed with cold acetone. The 106 parts of product was purified by recrystallization from acetone as fine white crystals which melt at 177°- 178°C.
Therapeutic Function
Tranquilizer; Anticholinergic
Benactyzine Preparation Products And Raw materials
Raw materials
Preparation Products
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