ChemicalBook > CAS DataBase List > BENACTYZINE HYDROCHLORIDE

BENACTYZINE HYDROCHLORIDE

Product Name
BENACTYZINE HYDROCHLORIDE
CAS No.
57-37-4
Chemical Name
BENACTYZINE HYDROCHLORIDE
Synonyms
cedad;fobex;Amizyl;Amisil;amisyl;amizil;cafron;ea2092;katron;parpon
CBNumber
CB2154541
Molecular Formula
C20H26ClNO3
Formula Weight
363.88
MOL File
57-37-4.mol
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BENACTYZINE HYDROCHLORIDE Property

Melting point:
177-179 °C(lit.)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly, Heated), Methanol (Slightly)
form 
Solid
color 
Crystals from Me2CO
Merck 
14,1029
CAS DataBase Reference
57-37-4(CAS DataBase Reference)
EPA Substance Registry System
Benzeneacetic acid, .alpha.-hydroxy-.alpha.-phenyl-, 2-(diethylamino)ethyl ester, hydrochloride (57-37-4)
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Safety

Hazard Codes 
T
Risk Statements 
23/24/25
Safety Statements 
36/37/39-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
DD2800000
HS Code 
2922.50.4000
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
LD50 orl-rat: 184 mg/kg TXAPA9 1,42,59
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
B0053
Product name
Benactyzine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$172
Updated
2024/03/01
TRC
Product number
B119600
Product name
Benactyzine Hydrochloride
Packaging
5g
Price
$110
Updated
2021/12/16
Chem-Impex
Product number
37634
Product name
Benactyzinehydrochloride,98%(Assaybytitration,HPLC)
Purity
98%(Assaybytitration,HPLC)
Packaging
5G
Price
$181.44
Updated
2021/12/16
ApexBio Technology
Product number
C6667
Product name
Benactyzine Hydrochloride
Packaging
100mg
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-8073
Product name
Benactyzine Hydrochloride
Purity
99.69%
Packaging
100mg
Price
$72
Updated
2021/12/16
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BENACTYZINE HYDROCHLORIDE Chemical Properties,Usage,Production

Originator

Suavitil,Merck Sharp and Dohme,US,1957

Uses

Benactyzine Hydrochloride is an antagonist of acetylcholine in the central and peripheral nervous system. Benactyzine Hydrochloride is used as an antispasmodic.

Manufacturing Process

114 parts of ethyl benzilate, 175 parts of β-diethylaminoethanol and 0.2 part of metallic sodium were placed in a flask attached to a total-reflux variable take-off fractionating column. The pressure was reduced to 100 mm and heat was applied by an oil bath the temperature of which was slowly raised to 90°C. During three hours of heating 17 parts of ethanol distilled (35.5°C). When the distillation of the ethanol became slow, the bath temperature was raised to 120°C. When the vapor temperature indicated distillation of the amino alcohol the take off valve was closed and the mixture was refluxed for one hour. At the end of this period the vapor temperature had dropped and two more parts of ethanol were distilled, The remaining aminoalcohol was slowly distilled for three hours. The pressure was then reduced to 20 mm and the remainder of the aminoalcohol distilled at 66°C. During the reaction the color of the solution changed from yellow to deep red. The residue was dissolved in 500 parts of ether, washed once with dilute brine, and three times with water, dried over sodium sulfate and finally dried over calcium sulfate. 500 parts of a saturated solution of HCl in absolute ether was added and the resulting precipitate filtered. Dry HCl gas was passed into the filtrate to a slight excess and the precipitate again filtered. The combined precipitates were washed with cold acetone. The 106 parts of product was purified by recrystallization from acetone as fine white crystals which melt at 177°- 178°C.

Therapeutic Function

Tranquilizer; Anticholinergic

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, intradermal, and intravenous routes. Human systemic effects by ingestion of very small amounts: toxic psychosis. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NO, and HCl

BENACTYZINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Benzilic acid Ethylamine

Preparation Products

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BENACTYZINE HYDROCHLORIDE Suppliers

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View Lastest Price from BENACTYZINE HYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
Benactyzine Hydrochloride 57-37-4
Price
US $9.80/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
20 tons
Release date
2020-01-09

57-37-4, BENACTYZINE HYDROCHLORIDERelated Search:

RIMANTADINE HCL USP(CRM STANDARD) Benazepril hydrochloride Cetirizine dihydrochloride Rimantadine hydrochloride Ethambutol ETHYL BENZILATE Benactyzine Benzilic acid Ethylamine hydrochloride Methylbenactyzine bromide BENACTYZINE HYDROCHLORIDE 2,2-Diphenyl-2-ethoxyacetic acid (2-(N-sec-butyl-N-ethylamino)ethyl) e ster hydrochloride 2,2-Diphenyl-2-methoxyacetic acid (1-ethyl-3-piperidyl) ester hydrochl oride 2,2-Diphenyl-2-methoxyacetic acid (2-(N-ethyl-N-pentylamino)ethyl) est er hydrochloride Acetic acid, 2,2-diphenyl-2-ethoxy-, (2-(N-ethyl-N-propylamino)ethyl) ester, hydrochloride Piperilate hydrochloride N-METHYL L-QNB, [N-METHYL-3H]-

  • 2-(diethylamino)-ethanobenzilatehydrochloride
  • 2-(difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid
  • Benactyzine HCL
  • BENACTYZINE HYDROCHLORIDE 98+%
  • BENACTYCIN HYDROCHLORIDE
  • 2-(Diethylamino)ethyl benzilate hydrochloride, Benactyzine, α-Hydroxy-α-phenylbenzeneacetic acid 2-(diethylamino)ethyl ester
  • Amizyl
  • 2-(Difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid [czech]
  • 2-Diethylaminoethylester kyseliny benzilove hydrochlorid [czech]
  • Ai3-26379
  • Amisil
  • 2-DiethylaMinoethanol Benzilate-HCl
  • Benzilic Acid 2-(Diethylamino)ethyl Ester Hydrochloride 2-(Diethylamino)ethyl Benzilate Hydrochloride
  • ethyl 2-hydroxy-2,2-diphenylacetate hydrochloride
  • 2-Diethylaminoethyl 2-hydroxy-2,2-diphenylacetate hydrochloride
  • 2-diethylaminoethylesterkyselinybenzilovehydrochlorid
  • aktozin
  • amisyl
  • amitakon
  • amizil
  • arkadin
  • ay-5406
  • ay5406-1
  • benactyzinechloride
  • benaktin
  • benzeneaceticacid,alpha-hydroxy-alpha-phenyl-,2-(diethylamino)ethylester,
  • benzilatedudiethylamino-ethanolchlorhydrate
  • benzilicacidbeta-diethylaminoethylesterhydrochloride
  • beta-diethylaminoethylbenzilatehydrochloride
  • cafron
  • cedad
  • cevanol
  • destendo
  • diphenylglycollicacid2-(diethylamino)ethylesterhydrochloride
  • ea2092
  • fobex
  • -Hydroxy-phenylbenzeneaceticacid2-(diethy-lamino)ethylesterhydrochloride
  • ibiotyzil
  • katron
  • leucidil
  • lucidil
  • nervacton
  • nervatil
  • neuraktil
  • neurobenzil
  • neuroleptone
  • nutinal
  • parasan
  • parazan
  • parpon
  • phobex
  • procalm
  • prokalm
  • stoikon
  • suavitil
  • valladan
  • valladon
  • win5606