Benzilic acid Property

Melting point:

149-151 °C(lit.)

Boiling point:

180 °C

Density 

1.28

refractive index 

1.5805 (estimate)

Flash point:

180°C/22mm

storage temp. 

Store below +30°C.

solubility 

1.41g/l (experimental)

form 

Powder

pka

pKa (25°): 3.036

color 

White to cream-white

Water Solubility 

1.41 g/L (25 ºC)

Merck 

14,1080

BRN 

521402

Stability:

Stable. Incompatible with strong oxidizing agents. Combustible.

LogP

2.300

CAS DataBase Reference

76-93-7(CAS DataBase Reference)

NIST Chemistry Reference

Benzeneacetic acid, «alpha»-hydroxy-«alpha»-phenyl-(76-93-7)

EPA Substance Registry System

Benzilic acid (76-93-7)

Safety

Hazard Codes 

Xn

Risk Statements 

22-36/37/38-20/21/22

Safety Statements 

36-36/37/39-26

WGK Germany 

3

RTECS 

DD2064000

TSCA 

Yes

HS Code 

29181980

Hazardous Substances Data

76-93-7(Hazardous Substances Data)

Toxicity

LD50 orl-mus: 2 g/kg AIPTAK 116,154,58

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

Benzilic acid Chemical Properties,Usage,Production

Chemical Properties

white powder

Uses

Benzilic Acid is an impurity of Trospium (T892800), a tropine derivative with anticholinergic activity and a antiispasmodic agent.

Definition

ChEBI: Benzilic acid is a 2-hydroxy monocarboxylic acid.

Synthesis Reference(s)

The Journal of Organic Chemistry, 29, p. 1631, 1964 DOI: 10.1021/jo01029a509

Safety Profile

Moderately toxic by subcutaneousroute. Slightly toxic by ingestion. When heated todecomposition it emits acrid smoke and irritating vapors.

Purification Methods

Crystallise benzilic acid from *benzene (ca 6mL/g), or hot H2O. [Beilstein 10 IV 1256.]